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Cancers
Volume 12
Issue 2
10.3390/cancers12020414
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Case Report

Targeting Epidermal Growth Factor Receptor (EGFR) in Pediatric Colorectal Cancer

by
Maria Debora De Pasquale
1,
Alessandro Crocoli
2,
Tamara Caldaro
3,
Martina Rinelli
4,
Gian Paolo Spinelli
5,
Paola Francalanci
6,
Raffaele Cozza
1,
Alessandro Inserra
2 and
Evelina Miele
1,*
1
Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, 00165 Rome, Italy
2
Surgical Oncology Unit, Department of Surgery, IRCCS Bambino Gesù Children’s Hospital, 00165 Rome, Italy
3
Digestive Endoscopy and Surgery Unit, Department of Surgery, Bambino Gesù Children’s Hospital-IRCCS, 00165 Rome, Italy
4
Department of Laboratories, Genetic Unit, IRCCS Bambino Gesù Children’s Hospital, 00165 Rome, Italy
5
Oncology Unit, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Via Giustiniano, 04011 Aprilia, Italy
6
Department of Laboratories, Pathology Unit, IRCCS Bambino Gesù Children’s Hospital, 00165 Rome, Italy
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(2), 414; https://doi.org/10.3390/cancers12020414
Submission received: 31 December 2019 / Revised: 30 January 2020 / Accepted: 4 February 2020 / Published: 11 February 2020
(This article belongs to the Collection Targeting Solid Tumors)
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Abstract

Background: Colorectal carcinoma (CRC) is very rare in the pediatric and adolescent age range and clinical management is performed according to adult protocols. We report, for the first time in the literature, a case of a child with metastatic CRC successfully treated with panitumumab associated to chemotherapy. Methods: A twelve-year-old male was diagnosed with CRC with nodal metastasis and peritoneal neoplastic effusion. After performing a genetic evaluation, in light of the absence of mutations in RAS family genes, anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody, panitumumab, was added to chemotherapy FOLFOXIRI. Results: The child successfully responded to therapy with normalization of the Carbohydrate Antigen (CA) 19.9 value after the third cycle of treatment. After the sixth cycle, he underwent surgery that consisted in sigmoid resection with complete D3 lymphadenectomy. At histological evaluation, no residual neoplastic cells were detectable in the surgical specimen. He completed 12 cycles of chemotherapy plus panitumomab and he is alive without disease 14 months from diagnosis. Conclusions: Our results suggest performing mutational screening for colorectal cancer also in the pediatric setting, in order to orient treatment that should include targeted therapies.
Keywords: anti-EGFR; panitumumab; childhood; colorectal cancer anti-EGFR; panitumumab; childhood; colorectal cancer

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MDPI and ACS Style

De Pasquale, M.D.; Crocoli, A.; Caldaro, T.; Rinelli, M.; Spinelli, G.P.; Francalanci, P.; Cozza, R.; Inserra, A.; Miele, E. Targeting Epidermal Growth Factor Receptor (EGFR) in Pediatric Colorectal Cancer. Cancers 2020, 12, 414. https://doi.org/10.3390/cancers12020414

AMA Style

De Pasquale MD, Crocoli A, Caldaro T, Rinelli M, Spinelli GP, Francalanci P, Cozza R, Inserra A, Miele E. Targeting Epidermal Growth Factor Receptor (EGFR) in Pediatric Colorectal Cancer. Cancers. 2020; 12(2):414. https://doi.org/10.3390/cancers12020414

Chicago/Turabian Style

De Pasquale, Maria Debora, Alessandro Crocoli, Tamara Caldaro, Martina Rinelli, Gian Paolo Spinelli, Paola Francalanci, Raffaele Cozza, Alessandro Inserra, and Evelina Miele. 2020. "Targeting Epidermal Growth Factor Receptor (EGFR) in Pediatric Colorectal Cancer" Cancers 12, no. 2: 414. https://doi.org/10.3390/cancers12020414

APA Style

De Pasquale, M. D., Crocoli, A., Caldaro, T., Rinelli, M., Spinelli, G. P., Francalanci, P., Cozza, R., Inserra, A., & Miele, E. (2020). Targeting Epidermal Growth Factor Receptor (EGFR) in Pediatric Colorectal Cancer. Cancers, 12(2), 414. https://doi.org/10.3390/cancers12020414

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