Next Article in Journal
Clinical Theragnostic Potential of Diverse miRNA Expressions in Prostate Cancer: A Systematic Review and Meta-Analysis
Next Article in Special Issue
Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells
Previous Article in Journal
Long Non-Coding RNA HOTAIR in Breast Cancer Therapy
Previous Article in Special Issue
Targeted Dual Intervention-Oriented Drug-Encapsulated (DIODE) Nanoformulations for Improved Treatment of Pancreatic Cancer
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Nanoemulsions as Delivery Systems for Poly-Chemotherapy Aiming at Melanoma Treatment

1
Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10125 Turin, Italy
2
Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Italy
3
San Giovanni Bosco Hospital, Piazza del Donatore di Sangue 3, 10154 Turin, Italy
4
Department of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont (UPO), via Solaroli 17, 28100 Novara, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(5), 1198; https://doi.org/10.3390/cancers12051198
Submission received: 6 April 2020 / Revised: 3 May 2020 / Accepted: 7 May 2020 / Published: 9 May 2020
(This article belongs to the Collection Cancer Nanomedicine)

Abstract

Aims: Advanced melanoma is characterized by poor outcome. Despite the number of treatments having been increased over the last decade, current pharmacological strategies are only partially effective. Therefore, the improvement of the current systemic therapy is worthy of investigation. Methods: a nanotechnology-based poly-chemotherapy was tested at preclinical level. Temozolomide, rapamycin, and bevacizumab were co-loaded as injectable nanoemulsions for total parenteral nutrition (Intralipid®), due to suitable devices, and preliminarily tested in vitro on human and mouse cell models and in vivo on the B16-F10 melanoma mouse model. Results: Drug combination was efficiently loaded in the liquid lipid matrix of Intralipid®, including bevacizumab monoclonal antibody, leading to a fast internalization in tumour cells. An increased cytotoxicity towards melanoma cells, as well as an improved inhibition of tumour relapse, migration, and angiogenesis were demonstrated in cell models for the Intralipid®-loaded drug combinations. In preliminary in vivo studies, the proposed approach was able to reduce tumour growth significantly, compared to controls. A relevant efficacy towards tumour angiogenesis and mitotic index was determined and immune response was involved. Conclusions: In these preliminary studies, Intralipid® proved to be a safe and versatile poly-chemotherapy delivery system for advanced melanoma treatment, by acting on multiple mechanisms.
Keywords: nanoemulsions; Intralipid®; temozolomide; rapamycin; bevacizumab; melanoma nanoemulsions; Intralipid®; temozolomide; rapamycin; bevacizumab; melanoma
Graphical Abstract

Share and Cite

MDPI and ACS Style

Dianzani, C.; Monge, C.; Miglio, G.; Serpe, L.; Martina, K.; Cangemi, L.; Ferraris, C.; Mioletti, S.; Osella, S.; Gigliotti, C.L.; et al. Nanoemulsions as Delivery Systems for Poly-Chemotherapy Aiming at Melanoma Treatment. Cancers 2020, 12, 1198. https://doi.org/10.3390/cancers12051198

AMA Style

Dianzani C, Monge C, Miglio G, Serpe L, Martina K, Cangemi L, Ferraris C, Mioletti S, Osella S, Gigliotti CL, et al. Nanoemulsions as Delivery Systems for Poly-Chemotherapy Aiming at Melanoma Treatment. Cancers. 2020; 12(5):1198. https://doi.org/10.3390/cancers12051198

Chicago/Turabian Style

Dianzani, Chiara, Chiara Monge, Gianluca Miglio, Loredana Serpe, Katia Martina, Luigi Cangemi, Chiara Ferraris, Silvia Mioletti, Sara Osella, Casimiro Luca Gigliotti, and et al. 2020. "Nanoemulsions as Delivery Systems for Poly-Chemotherapy Aiming at Melanoma Treatment" Cancers 12, no. 5: 1198. https://doi.org/10.3390/cancers12051198

APA Style

Dianzani, C., Monge, C., Miglio, G., Serpe, L., Martina, K., Cangemi, L., Ferraris, C., Mioletti, S., Osella, S., Gigliotti, C. L., Boggio, E., Clemente, N., Dianzani, U., & Battaglia, L. (2020). Nanoemulsions as Delivery Systems for Poly-Chemotherapy Aiming at Melanoma Treatment. Cancers, 12(5), 1198. https://doi.org/10.3390/cancers12051198

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop