Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management

Gamez, Mauricio E.; Blakaj, Adriana; Zoller, Wesley; Bonomi, Marcelo; Blakaj, Dukagjin M.

doi:10.3390/cancers12061651

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Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management

by

Mauricio E. Gamez

^1,*,

Adriana Blakaj

²,

Wesley Zoller

¹

,

Marcelo Bonomi

³

and

Dukagjin M. Blakaj

¹

Division of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA

²

Department of Therapeutic Radiology, Yale School of Medicine, 35 Park St., New Haven, CT 06519, USA

³

Department of Internal Medicine, Division of Medical Oncology, The Ohio State University Wexner Medical Center, 320 West 10th Avenue, Columbus, OH 43210, USA

^*

Author to whom correspondence should be addressed.

Cancers 2020, 12(6), 1651; https://doi.org/10.3390/cancers12061651

Submission received: 25 May 2020 / Revised: 14 June 2020 / Accepted: 15 June 2020 / Published: 22 June 2020

(This article belongs to the Special Issue Emerging Concepts in Treatment of Laryngeal Cancer)

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Abstract

Laryngeal squamous cell carcinoma is the second most common head and neck cancer. Its pathogenesis is strongly associated with smoking. The management of this disease is challenging and mandates multidisciplinary care. Currently, accepted treatment modalities include surgery, radiation therapy, and chemotherapy—all focused on improving survival while preserving organ function. Despite changes in smoking patterns resulting in a declining incidence of laryngeal cancer, the overall outcomes for this disease have not improved in the recent past, likely due to changes in treatment patterns and treatment-related toxicities. Here, we review emerging concepts and novel strategies in the use of radiation therapy in the management of laryngeal squamous cell carcinoma that could improve the relationship between tumor control and normal tissue damage (therapeutic ratio).

Keywords: laryngeal cancer; radiotherapy; IMRT; IGRT; SABR; de-escalation therapy

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MDPI and ACS Style

Gamez, M.E.; Blakaj, A.; Zoller, W.; Bonomi, M.; Blakaj, D.M. Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management. Cancers 2020, 12, 1651. https://doi.org/10.3390/cancers12061651

AMA Style

Gamez ME, Blakaj A, Zoller W, Bonomi M, Blakaj DM. Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management. Cancers. 2020; 12(6):1651. https://doi.org/10.3390/cancers12061651

Chicago/Turabian Style

Gamez, Mauricio E., Adriana Blakaj, Wesley Zoller, Marcelo Bonomi, and Dukagjin M. Blakaj. 2020. "Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management" Cancers 12, no. 6: 1651. https://doi.org/10.3390/cancers12061651

APA Style

Gamez, M. E., Blakaj, A., Zoller, W., Bonomi, M., & Blakaj, D. M. (2020). Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management. Cancers, 12(6), 1651. https://doi.org/10.3390/cancers12061651

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management

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