Next Article in Journal
Locoregional Therapy Approaches for Hepatocellular Carcinoma: Recent Advances and Management Strategies
Next Article in Special Issue
Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies
Previous Article in Journal
Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers
Previous Article in Special Issue
Diagnosis and Treatment of Primary Cutaneous B-Cell Lymphomas: State of the Art and Perspectives
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 12
Issue 7
10.3390/cancers12071912
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type

by
Valdemar Priebe
1,†,
Giulio Sartori
1,†,
Sara Napoli
1,
Elaine Yee Lin Chung
1,
Luciano Cascione
1,2,
Ivo Kwee
1,2,3,
Alberto Jesus Arribas
1,2,
Afua Adjeiwaa Mensah
1,
Andrea Rinaldi
1,
Maurilio Ponzoni
4,
Emanuele Zucca
1,5,
Davide Rossi
1,5,
Dimitar Efremov
6,
Georg Lenz
7,
Margot Thome
8 and
Francesco Bertoni
1,5,*
1
Institute of Oncology Research, Faculty of Biomedical Sciences, USI, 6500 Bellinzona, Switzerland
2
Swiss Institute of Bioinformatics (SIB), 1015 Lausanne, Switzerland
3
Dalle Molle Institute for Artificial Intelligence (IDSIA), 6928 Manno, Switzerland
4
San Raffaele Scientific Institute, Vita Salute University, 20132 Milan, Italy
5
Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland
6
Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy
7
Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, 48149 Münster, Germany
8
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
*
Author to whom correspondence should be addressed.
†
Both of these authors contributed equally to this work.
Cancers 2020, 12(7), 1912; https://doi.org/10.3390/cancers12071912
Submission received: 23 June 2020 / Revised: 9 July 2020 / Accepted: 11 July 2020 / Published: 15 July 2020
(This article belongs to the Special Issue B Cell Malignancies (including B Cell Lymphoma, Multiple Myeloma and B-CLL))
Browse Figures
Versions Notes

Abstract

Diffuse large B cell lymphoma (DLBCL) is a heterogenous disease that has been distinguished into at least two major molecular entities, the germinal center-like B cell (GCB) DLBCL and activated-like B cell (ABC) DLBCL, based on transcriptome expression profiling. A recurrent ch11q24.3 gain is observed in roughly a fourth of DLBCL cases resulting in the overexpression of two ETS transcription factor family members, ETS1 and FLI1. Here, we knocked down ETS1 expression by siRNA and analyzed expression changes integrating them with ChIP-seq data to identify genes directly regulated by ETS1. ETS1 silencing affected expression of genes involved in B cell signaling activation, B cell differentiation, cell cycle, and immune processes. Integration of RNA-Seq (RNA sequencing) data and ChIP-Seq (chromatin immunoprecipitation sequencing) identified 97 genes as bona fide, positively regulated direct targets of ETS1 in ABC-DLBCL. Among these was the Fc receptor for IgM, FCMR (also known as FAIM3 or Toso), which showed higher expression in ABC- than GCB-DLBCL clinical specimens. These findings show that ETS1 is contributing to the lymphomagenesis in a subset of DLBCL and identifies FCMR as a novel target of ETS1, predominantly expressed in ABC-DLBCL.
Keywords: diffuse large B cell lymphoma; ETS1; BCL6; PRDM1 diffuse large B cell lymphoma; ETS1; BCL6; PRDM1

Share and Cite

MDPI and ACS Style

Priebe, V.; Sartori, G.; Napoli, S.; Chung, E.Y.L.; Cascione, L.; Kwee, I.; Arribas, A.J.; Mensah, A.A.; Rinaldi, A.; Ponzoni, M.; et al. Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type. Cancers 2020, 12, 1912. https://doi.org/10.3390/cancers12071912

AMA Style

Priebe V, Sartori G, Napoli S, Chung EYL, Cascione L, Kwee I, Arribas AJ, Mensah AA, Rinaldi A, Ponzoni M, et al. Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type. Cancers. 2020; 12(7):1912. https://doi.org/10.3390/cancers12071912

Chicago/Turabian Style

Priebe, Valdemar, Giulio Sartori, Sara Napoli, Elaine Yee Lin Chung, Luciano Cascione, Ivo Kwee, Alberto Jesus Arribas, Afua Adjeiwaa Mensah, Andrea Rinaldi, Maurilio Ponzoni, and et al. 2020. "Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type" Cancers 12, no. 7: 1912. https://doi.org/10.3390/cancers12071912

APA Style

Priebe, V., Sartori, G., Napoli, S., Chung, E. Y. L., Cascione, L., Kwee, I., Arribas, A. J., Mensah, A. A., Rinaldi, A., Ponzoni, M., Zucca, E., Rossi, D., Efremov, D., Lenz, G., Thome, M., & Bertoni, F. (2020). Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type. Cancers, 12(7), 1912. https://doi.org/10.3390/cancers12071912

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop