High Basal Maximal Standardized Uptake Value (SUVmax) in Follicular Lymphoma Identifies Patients with a Low Risk of Long-Term Relapse
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. PET/CT Scanning
2.2. Patient Selection
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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All Patients | Group A | Group B | p Value * | |
---|---|---|---|---|
Tot = 94 N° (%) | Tot = 34 N° (%) | Tot = 60 N° (%) | ||
Histological Grading | 0.409 | |||
1–2 | 47 (50) | 21 (44.7) | 26 (55.3) | |
3a | 41 (43.6) | 11 (26.8) | 30 (73.2) | |
Undetermined | 5 (5.3) | 2 (40) | 3 (60) | |
Ann Arbor Stage | 0.01 | |||
I–II | 38 (40.4) | 19 (50) | 19 (50) | |
III–IV | 56 (59.6) | 15 (26.8) | 41 (73.2) | |
Bulky Disease | 0.191 | |||
No | 61 (83.6) | 22 (36.1) | 39 (63.9) | |
Yes | 12 (16.4) | 2 (16.7) | 10 (83.3) | |
Bone Marrow Involvement | 0.869 | |||
Negative | 63 (67.7) | 22 (34.9) | 41 (65.1) | |
Positive | 30 (32.3) | 11 (36.7) | 19 (63.3) | |
Extranodal Disease | 0.204 | |||
No | 56 (60.2) | 17 (30.4) | 39 (69.6) | |
Yes | 37 (39.8) | 16 (43.2) | 21 (56.8) | |
B Symptoms | 0.496 | |||
No | 82 (88.2) | 31 (37.8) | 51 (62.2) | |
Yes | 11 (11.8) | 3 (27.8) | 8 (72.2) | |
N° Nodal Sites | 0.065 | |||
≤3 | 34 (38.6) | 16 (47.1) | 18 (52.9) | |
>3 | 54 (61.4) | 15 (27.8) | 39 (72.2) | |
β2-Microglobulin | 0.252 | |||
≤ULN | 64 (82.1) | 24 (37.5) | 42(62.5) | |
>ULN | 14 (17.9) | 3 (21.4) | 11 (78.6) | |
LDH | 0.367 | |||
≤ULN | 70 (85.4) | 27 (38.6) | 43 (61.4) | |
>ULN | 12 (14.6) | 3 (25) | 9 (75) | |
FLIPI | 0.57 | |||
Low risk | 43 (48.3) | 18 (41.8) | 25 (58.1) | |
Intermediate risk | 28 (31.5) | 10 (35.7) | 18 (64.3) | |
High risk | 18 (20.2) | 5 (27.8) | 13(72.2) | |
FLIPI 2 | 0.36 | |||
Low risk | 56 (66.7) | 20 (35.7) | 36 (64.3) | |
Intermediate risk | 20 (23.8) | 8 (40) | 12 (60) | |
High risk | 8 (9.5) | 1 (12.5) | 7 (87.5) |
PFS at Time of Follow-Up | p Value * | |||
---|---|---|---|---|
All Patients N° (%) | Group A N° (%) | Group B N° (%) | ||
Histological Grading | ||||
1–2 | 37 (78.7) | 14 (66.7) | 23 (88.5) | 0.046 |
3a | 34 (82.9) | 7 (63.6) | 27 (90) | 0.031 |
Undetermined | 5 (100) | 2 (100) | 3 (100) | |
Ann Arbor Stage | ||||
I–II | 31 (81.6) | 14 (73.7) | 17 (89.5) | 0.075 |
III–IV | 46 (82.1) | 9 (60) | 37 (90.2) | 0.014 |
Bulky Disease | ||||
No | 47 (77) | 12 (54.5) | 35 (89.7) | <0.001 |
Yes | 10 (83.3) | 2 (100) | 8 (80) | 0.456 |
Bone Marrow Involvement | ||||
No | 53 (84.1) | 15 (68.2) | 38 (92.7) | 0.003 |
Yes | 23 (76.7) | 7 (63.6) | 16 (84.2) | 0.855 |
Extranodal Disease | ||||
No | 47 (83.9) | 11 (64.7) | 36 (92.3) | 0.001 |
Yes | 29 (78.4) | 11 (68.8) | 18 (85.7) | 0.855 |
B Symptoms | ||||
No | 66 (80.5) | 20 (64.5) | 46 (90.2) | 0.001 |
Yes | 10 (90.9) | 3 (100) | 7 (87.5) | 0.386 |
N° Nodal Sites | ||||
≤3 | 29 (85.3) | 12 (75) | 17 (94.4) | 0.028 |
>3 | 43 (79.6) | 9 (60) | 34 (87.2) | 0.059 |
Β2-Microglobulin | ||||
≤ULN | 52 (81.3) | 16 (66.7) | 36 (90) | 0.015 |
>ULN | 12 (85.7) | 2 (66.7) | 10 (90.9) | 0.307 |
LDH | ||||
≤ULN | 58 (82.9) | 19 (70.4) | 39 (90.7) | 0.026 |
>ULN | 9 (75) | 1 (33.3) | 8 (88.9) | 0.093 |
FLIPI | ||||
Low risk | 35 (81.4) | 12 (66.7) | 23 (92) | 0.012 |
Intermediate risk | 27 (96.4) | 9 (90) | 18 (100) | 0.180 |
High risk | 12 (66.7) | 2 (40) | 10 (76.9) | 0.347 |
FLIPI 2 | ||||
Low risk | 48 (62.5) | 15 (75) | 33 (91.7) | 0.021 |
Intermediate risk | 17 (85) | 5 (62.5) | 12 (100) | 0.137 |
High risk | 5 (62.5) | 0 (0) | 5 (71.4) | 0.327 |
Treatment/Response | All Patients | Group A | Group B | p Value * |
---|---|---|---|---|
DF-Pts/Tot (%) | DF-Pts/Tot (%) | DF-Pts/Tot (%) | ||
I line Therapy | ||||
Radiotherapy | 16/22 (72.7) | 7/12 (58.3) | 9/10 (90) | 0.124 |
R-CHOP | 22/27 (81.5) | 7/9 (77.8) | 15/18 (83.3) | 0.278 |
R-Benda | 30/34 (88.2) | 5/7 (71.4) | 25/27 (92.6) | 0.062 |
Other therapies | 7/11 (66) | 4/7 (57) | 3/4 (75) | 0.480 |
Response after induction | ||||
CR | 65/78 (83.3) | 17/26 (65.4) | 48/52 (90.3) | 0.007 |
PR | 5/8 (62.5) | 2/4 (50) | 3/4 (75) | 0.364 |
Transformation at relapse | ||||
No | 77/91 (84.6) | 23/32 (71.9) | 54/59 (91.5) | 0.008 |
Yes | 0/3 | 0/2 | 0/1 | 0.225 |
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Assanto, G.M.; Ciotti, G.; Brescini, M.; De Luca, M.L.; Annechini, G.; D’Elia, G.M.; Agrippino, R.; Del Giudice, I.; Martelli, M.; Chiaravalloti, A.; et al. High Basal Maximal Standardized Uptake Value (SUVmax) in Follicular Lymphoma Identifies Patients with a Low Risk of Long-Term Relapse. Cancers 2021, 13, 2876. https://doi.org/10.3390/cancers13122876
Assanto GM, Ciotti G, Brescini M, De Luca ML, Annechini G, D’Elia GM, Agrippino R, Del Giudice I, Martelli M, Chiaravalloti A, et al. High Basal Maximal Standardized Uptake Value (SUVmax) in Follicular Lymphoma Identifies Patients with a Low Risk of Long-Term Relapse. Cancers. 2021; 13(12):2876. https://doi.org/10.3390/cancers13122876
Chicago/Turabian StyleAssanto, Giovanni Manfredi, Giulia Ciotti, Mattia Brescini, Maria Lucia De Luca, Giorgia Annechini, Gianna Maria D’Elia, Roberta Agrippino, Ilaria Del Giudice, Maurizio Martelli, Agostino Chiaravalloti, and et al. 2021. "High Basal Maximal Standardized Uptake Value (SUVmax) in Follicular Lymphoma Identifies Patients with a Low Risk of Long-Term Relapse" Cancers 13, no. 12: 2876. https://doi.org/10.3390/cancers13122876