MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma
Abstract
:Simple Summary
Abstract
1. Introduction
2. miRNAs in HNSCC Metabolism
2.1. miR-218, miR-10a, miR-340
2.2. miR-143, miR-125-b-5p
2.3. miR-210
2.4. miR-31-5p
3. Exosomal miRNAs in HNSCC Tumor Microenvironment
3.1. Exosomal miRNAs Crosstalk between HNSCC and TAMs
3.2. Exosomal miRNAs Crosstalk between HNSCC and TILs
3.3. Exosomal miRNAs Crosstalk between HNSCC and CAFs
3.4. Exosomal miRNAs Crosstalk between HNSCC and ECs
4. Clinical Implications of miRNA in HNSCC
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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miRNA | Cancer Subtype | Application | Reference |
---|---|---|---|
miR-218 | OSCC | Downregulation of miRNA-218 increases proliferation and glucose uptake by activating GLUT1 expression | [33] |
miR-340 | OSCC | Suppression of miRNA-340 activates GLUT1 expression, inducing proliferation, colony formation, lactate secretion, and glucose uptake rate | [34] |
miR-10a | OSCC | miR-10a overexpression promotes glucose uptake and cell proliferation | [35] |
miR-143 | OSCC | Overexpression of miR-143 inhibited proliferation, migration, invasion, and glucose metabolism through targeting HK2 | [36] |
miR-125b-5p | LSCC | miR-125b-5p transfection decreased the glucose consumption and lactate production by targeting HK2, which inhibits cells growth | [37] |
miR-210 | OPSCC | HIF-1α-induced miR-210 silence ISCU expression, which promotes a switch from mitochondrial respiration to glycolytic metabolism | [38] |
miR-31-5p | OSCC | miR-31-5p suppresses ACOX1 expression, enhancing MMP-9 and PGE2, promoting migration and invasion | [39] |
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Shiah, S.-G.; Chou, S.-T.; Chang, J.-Y. MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma. Cancers 2021, 13, 5604. https://doi.org/10.3390/cancers13225604
Shiah S-G, Chou S-T, Chang J-Y. MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma. Cancers. 2021; 13(22):5604. https://doi.org/10.3390/cancers13225604
Chicago/Turabian StyleShiah, Shine-Gwo, Sung-Tau Chou, and Jang-Yang Chang. 2021. "MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma" Cancers 13, no. 22: 5604. https://doi.org/10.3390/cancers13225604