A Comprehensive Prospective Comparison of Acute Skin Toxicity after Hypofractionated and Normofractionated Radiation Therapy in Breast Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
3.1. Dose Distribution PTV
3.2. Differences between CTCAE Scores
3.3. Differences between Skindex-16
3.4. Differences of Skin Thickness
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | CF | HF | Total | |
---|---|---|---|---|
n (%) | 38 (47.5%) | 42 (52.5%) | 80 (100.0%) | |
Age | ||||
Mean (SD) | 55.6 (11.9) | 61.3 (13.0) | 58.6 (12.8) | |
Body Mass Index | ||||
Mean (SD) | 25.1 (3.8) | 24.7 (4.5) | 24.9 (4.2) | |
Diabetes Mellitus | ||||
No | 37 (97.4%) | 42 (100.0%) | 79 (98.8%) | |
Smoker | ||||
No | 36 (94.8%) | 42 (100.0%) | 78 (97.5%) | |
Cup-Size | ||||
A | 1 (2.6%) | 8 (19.1%) | 9 (11.3%) | |
B | 19 (50.0%) | 13 (31.0.%) | 32 (40.0%) | |
C | 10 (26.3%) | 10 (23.8%) | 20 (25.0%) | |
D | 4 (10.5%) | 7 (16.7%) | 11 (13.8%) | |
E | 1 (2.6%) | 1 (2.4%) | 2 (2.5%) | |
F | 0 (0.0%) | 1 (2.4%) | 1 (1.3%) | |
Side | ||||
Right | 25 (65.8%) | 23 (54.8%) | 48 (60.0%) | |
Left | 13 (34.2%) | 19 (45.3%) | 32 (40.0%) | |
Topic Cremes | ||||
Bepanthen | 16 (42.1%) | 16 (38.1%) | 32 (40.0%) | |
No Creme | 15 (39.5%) | 18 (42.9%) | 33 (41.3%) | |
Anthyllis | 4 (10.5%) | 4 (9.5%) | 8 (10.0%) | |
Both | 3 (7.9%) | 4 (9.5%) | 7 (8.8%) | |
Surgery Typ | ||||
BET | 30 (79.0%) | 41 (97.6%) | 71 (88.8%) | |
Mastectomy | 7 (18.4%) | 1 (2.4%) | 8 (10.0%) | |
others | 1 (2.6%) | 0 (0.0%) | 1 (1.3%) | |
Lymph Node surgery | ||||
SLNB | 16 (42.1%) | 39 (92.9%) | 55 (68.8%) | |
None | 12 (31.6%) | 0 (0.0%) | 12 (15.0%) | |
ALND | 10 (26.3%) | 3 (7.1%) | 13 (16.3%) | |
Chemotherapy | ||||
None | 29 (76.3%) | 38 (90.5%) | 67 (83.8%) | |
Neo-Adjuvant | 8 (21.1%) | 4 (9.5%) | 12 (15.0%) | |
Adjuvant | 1 (2.6%) | 0 (0.0%) | 1 (1.3%) | |
Lymph node irradiation | ||||
0 | 24 (63.2%) | 40 (95.2%) | 64 (80.0%) | |
1 | 14 (36.8%) | 1 (2.4%) | 15 (18.8%) | |
Photon Energy | ||||
6 MV | 22 (57.9%) | 21 (50.0%) | 43 (53.8%) | |
6/15 MV | 12 (31.6%) | 15 (35.7%) | 27 (33.8%) | |
6/10 MV | 4 (10.53%) | 1 (2.38%) | 5 (6.25%) | |
Boost | ||||
Yes | 20 (52.6%) | 29 (69.1%) | 49 (61.3%) | |
No | 18 (47.4%) | 13 (31.0%) | 31 (38.8%) |
Variable | T | CF | HF | CF vs. HF |
---|---|---|---|---|
Emotions | ||||
T0 | 0 (8.9) | 0 (4.8) | 0 (0; 0) p = 0.68 | |
T1 | 19.1 (25.0) | 7.1 (27.4) | 11.9 (0; 14.3) p = 0.05 | |
T2 | 0.0 (7.1) | 0 (13.1) | 0.0 (0; 0.0) p = 0.76 | |
Symptoms | ||||
T0 | 0 (12.5) | 4.2 (12.5) | −4.2 (0; 0) p = 0.79 | |
T1 | 33.3 (41.7) | 29.2 (41.7) | 4.2 (−0.0; 20.8) p = 0.11 | |
T2 | 8.3 (17.7) | 4.17 (25.0) | 4.2 (0; 4.2) p = 0.55 | |
Functioning | ||||
T0 | 0 (6.67) | 0 (0.0) | 0 (0; 0) p = 0.13 | |
T1 | 6.7 (16.67) | 0 (10.0) | 6.7 (0; 6.7) p = 0.15 | |
T2 | 0 (6.7) | 0 (3.3) | 0 (0; 0) p = 0.57 | |
Total | ||||
T0 | 1.0 (8.3) | 2.1 (6.3) | −1.0 (−1.0; 1.04) p = 0.84 | |
T1 | 20.8 (25.8) | 8.3 (27.1) | 12.5 (−1.0; 14.6) p = 0.04 | |
T2 | 3.7 (7.6) | 2.1 (9.6) | 1.6 (−2.1; 3.1) p = 0.55 |
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Borm, K.J.; Kleine Vennekate, J.; Vagedes, J.; Islam, M.O.A.; Duma, M.N.; Loos, M.; Combs, S.E.; Schiller, K.; Klusen, S.; Paepke, S.; et al. A Comprehensive Prospective Comparison of Acute Skin Toxicity after Hypofractionated and Normofractionated Radiation Therapy in Breast Cancer. Cancers 2021, 13, 5826. https://doi.org/10.3390/cancers13225826
Borm KJ, Kleine Vennekate J, Vagedes J, Islam MOA, Duma MN, Loos M, Combs SE, Schiller K, Klusen S, Paepke S, et al. A Comprehensive Prospective Comparison of Acute Skin Toxicity after Hypofractionated and Normofractionated Radiation Therapy in Breast Cancer. Cancers. 2021; 13(22):5826. https://doi.org/10.3390/cancers13225826
Chicago/Turabian StyleBorm, Kai J., Johanne Kleine Vennekate, Jan Vagedes, Mohammad O. A. Islam, Marciana N. Duma, Maximilian Loos, Stephanie E. Combs, Kilian Schiller, Sophie Klusen, Stefan Paepke, and et al. 2021. "A Comprehensive Prospective Comparison of Acute Skin Toxicity after Hypofractionated and Normofractionated Radiation Therapy in Breast Cancer" Cancers 13, no. 22: 5826. https://doi.org/10.3390/cancers13225826