Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Genetic Alterations of KRAS in Human Cancers
3. Multiple Faces of KRAS-Mutated NSCLC
4. Oncogenic KRAS Regulates the Tumor Microenvironment (TME)
5. Covalent KRAS G12C Inhibitors for KRAS-Mutated NSCLC
6. Resistance Mechanisms for Anti-KRAS-G12C Therapies
7. Combined Therapies Involving Targeting of Oncogenic KRAS plus Other Targeted Drugs for KRAS-Mutated NSCLC
8. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Drug | Sponsor | NCT Number | Trial Name | Phase | Disease or Condition | Combination Therapy * |
---|---|---|---|---|---|---|
AMG510 (sotorasib) | Amgen | NCT03600883 | CodeBreaK 100 | 1/2 | Advanced solid tumors | PD-1 or PD-L1 antibodies |
NCT04185883 | CodeBreaK 101 | 1/2 | Advanced solid tumors | AMG404 (PD-1 antibody) | ||
Trametinib (MEK inhibitor) | ||||||
RMC-4630 (SHP2 inhibitor) | ||||||
Afatinib (EGFR-TKI) | ||||||
Pembrolizumab (PD-1 antibody) | ||||||
Chemotherapy (CBDCA, PEM, DTX) | ||||||
Atezolizumab (PD-L1 antibody) | ||||||
Everolimus (mTOR inhibitor) | ||||||
Palbociclib (CDK4/6 inhibitor) | ||||||
MVASI® (VEGF antibody) | ||||||
TNO155 (SHP2 inhibitor) | ||||||
Revolution Medicines | NCT05054725 | 2 | Advanced NSCLC | RMC-4630 (SHP2 inhibitor) | ||
MRTX849 (adagrasib) | Mirati | NCT03785249 | KRYSTAL 1 | 1/2 | Advanced solid tumors | Pembrolizumab (PD-1 antibody) |
Afatinib (EGFR-TKI) | ||||||
NCT04613596 | KRYSTAL 7 | 2 | Advanced NSCLC | Pembrolizumab (PD-1 antibody) | ||
NCT04975256 | KRYSTAL 14 | 1 | Advanced solid tumors | BI1701963 (SOS1 inhibitor) | ||
GDC-6036 | Roche/Genentech | NCT04449874 | 1 | Advanced solid tumors | Atezolizumab (PD-L1 antibody) | |
Bevacizumab (VEGF antibody) | ||||||
Erlotinib (EGFR-TKI) | ||||||
GDC-1971 (SHP2 inhibitor) | ||||||
D-1553 | InventisBio | NCT04585035 | 1/2 | Advanced solid tumors | Standard treatment | |
JDQ443 | Novartis | NCT04699188 | 1/2 | Advanced solid tumors | TNO155 (SHP2 inhibitor) | |
Spartalizumab (PD-1 antibody) | ||||||
LY3537982 | Eli Lilly | NCT04956640 | 1 | Advanced solid tumors | Abemaciclib (CDK4/6 inhibitor) | |
Erlotinib (EGFR-TKI) | ||||||
Sintilimab (PD-1 antibody) | ||||||
Temuterkib (ERK inhibitor) | ||||||
LY3295668 (Aurora kinase inhibitor) | ||||||
Cetuximab (EGFR antibody) | ||||||
BI1823911 | Boehringer | NCT04973163 | 1 | Advanced solid tumors | BI1701963 (SOS1 inhibitor) |
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Sunaga, N.; Miura, Y.; Kasahara, N.; Sakurai, R. Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer. Cancers 2021, 13, 5956. https://doi.org/10.3390/cancers13235956
Sunaga N, Miura Y, Kasahara N, Sakurai R. Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer. Cancers. 2021; 13(23):5956. https://doi.org/10.3390/cancers13235956
Chicago/Turabian StyleSunaga, Noriaki, Yosuke Miura, Norimitsu Kasahara, and Reiko Sakurai. 2021. "Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer" Cancers 13, no. 23: 5956. https://doi.org/10.3390/cancers13235956