Direct Interaction of miRNA and circRNA with the Oncosuppressor p53: An Intriguing Perspective in Cancer Research
Abstract
:Simple Summary
Abstract
1. Introduction
2. General Properties of miRNAs, circRNAs, and p53
2.1. Overview of miRNAs
2.2. Overview of circRNAs
2.3. Overview of p53
3. Interaction between p53 and miRNA
3.1. Overview of the Interplay between p53 and miRNAs
3.2. Direct Interaction between p53 and miRNA
3.2.1. Interaction between p53 and miR4749-5p
3.2.2. Interaction between p53 and miR21-3p
3.2.3. Interaction between p53 and mir23-5p
4. Interaction between p53 and circRNA
4.1. Overview of the Interplay between p53 and circRNA
4.2. Direct Interaction between p53 and circRNAs
4.2.1. Interaction between p53 and circCDR1as
4.2.2. Interaction between p53 and circFOXO3
4.2.3. Interaction between p53 and circDNMT1
5. Future Perspectives and Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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p53-RNA Interaction | Domain of p53 Involved in the Binding | Proposed Regulation Mechanism | Ref. |
---|---|---|---|
p53-miR4749 | DBD | Inhibition of p53-DNA interaction | [70] |
p53-miR21 | DBD | Inhibition of p53-DNA interaction | [69] |
p53-miR23 | CTD | Promotion of p53-miR128 interaction, favouring apoptosis due to oxidative stress | [68] |
p53-circCDR1 | DBD | Disruption of the p53-MDM2 complex, favouring an anticancer action | [80] |
p53-circFOXO3 | CTD | Promotion of MDM2 ubiquitination, favouring cell apoptosis | [81] |
p53-circCNM1 | CTD | Inhibition of p53 transcription leading to tumor cell proliferation | [82] |
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Bizzarri, A.R.; Cannistraro, S. Direct Interaction of miRNA and circRNA with the Oncosuppressor p53: An Intriguing Perspective in Cancer Research. Cancers 2021, 13, 6108. https://doi.org/10.3390/cancers13236108
Bizzarri AR, Cannistraro S. Direct Interaction of miRNA and circRNA with the Oncosuppressor p53: An Intriguing Perspective in Cancer Research. Cancers. 2021; 13(23):6108. https://doi.org/10.3390/cancers13236108
Chicago/Turabian StyleBizzarri, Anna Rita, and Salvatore Cannistraro. 2021. "Direct Interaction of miRNA and circRNA with the Oncosuppressor p53: An Intriguing Perspective in Cancer Research" Cancers 13, no. 23: 6108. https://doi.org/10.3390/cancers13236108