Pathological Changes in Pancreatic Carcinogenesis: A Review
Abstract
:Simple Summary
Abstract
1. Introduction
2. Pathology of Pancreatic Tumors
2.1. Primary Pancreatic Tumors
2.2. Secondary Pancreatic Tumors
3. Pathology of Precancerous Lesions of the Pancreas
3.1. Cancer-Related Lesions of the Pancreas
3.2. Pancreatic Intraepithelial Neoplasia (PanIN)
3.3. Pancreatic Cystic Lesions
4. Animal Models of Pancreatic Carcinogenesis
4.1. Hamster
4.2. Mouse
4.3. Other Models
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Precursor lesions of pancreatic cancer |
Acinar-to-ductal metaplasia (ADM) |
Cyst |
Pancreatic intraepithelial neoplasia (PanIN) |
Intraductal papillary mucinous neoplasm (IPMN) |
Surrogate markers of pancreatic cancer |
Focal fatty replacement |
Lobulocentric atrophy |
Duct dilatation/Cyst/IPMN |
Hamster | Precursor Lesions | |
---|---|---|
BOP | PanIN | Takahashi, 2018 |
BOP, ethionine-methionine | PanIN | Mizumoto, 1989 |
Bile reflux into the pancreatic duct | IPMN | Adachi, 2006 |
Mouse | ||
LSL-KrasG12D; Pdx1-Cre | PanIN | Hingorani, 2003 |
LSL-KrasG12D; Ptf/p48-Cre | PanIN | Hingorani, 2003 |
KIC model, Pdx-Cre; LSL-KrasG12D; Ink4a/Arflox/lox | PanIN | Aguirre, 2003 |
Pdx-Cre; LSL-KrasG12D; Trp53lox/lox; Ink4a/Arflox/lox | PanIN | Bardeesy, 2006 |
KPC model, Pdx1-Cre; LSL-KrasG12D; LSL-Trp53R172H/+ | PanIN | Hingorani, 2005 |
KD model, Pdx-Cre; LSL-KrasG12D; SMAD4lox/lox | PanIN, IPMN | Kojima, 2007 |
Ptf1a-Cre; LSL-KrasG12D; SMAD4lox/lox | PanIN, MCN | Izeradjene, 2007 |
Ptf1a-Cre; LSL-KrasG12D; Notch1lox/lox | PanIN | Hanlon, 2010 |
Ptf1a-Cre; LSL-KrasG12D; Tgfr2lox/lox | PanIN | Ijichi, 2006 |
Pdx1-Cre; LSL-KrasG12D; Brca2tr/Δ11 | PanIN | Skoulidis, 2010 |
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Yamakawa, K.; Ye, J.; Nakano-Narusawa, Y.; Matsuda, Y. Pathological Changes in Pancreatic Carcinogenesis: A Review. Cancers 2021, 13, 686. https://doi.org/10.3390/cancers13040686
Yamakawa K, Ye J, Nakano-Narusawa Y, Matsuda Y. Pathological Changes in Pancreatic Carcinogenesis: A Review. Cancers. 2021; 13(4):686. https://doi.org/10.3390/cancers13040686
Chicago/Turabian StyleYamakawa, Keiko, Juanjuan Ye, Yuko Nakano-Narusawa, and Yoko Matsuda. 2021. "Pathological Changes in Pancreatic Carcinogenesis: A Review" Cancers 13, no. 4: 686. https://doi.org/10.3390/cancers13040686