Brain Gliomas and Ollier Disease: Molecular Findings as Predictive Risk Factors?
Abstract
:Simple Summary
Abstract
1. Background
2. Methods
3. Results
3.1. Case Description
3.2. Diagnosis
3.3. Literature Review
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
Limitations of the Study
Advantages
Abbreviations
OD | Ollier Disease |
CT | Computed Tomography |
MRI | Magnetic Resonance Imaging |
WHO | World Health Organization |
CNS | Central Nervous System |
PFS | Progression Free Survival |
OS | Overall Survival |
MPFS | Malignant Progression-Free Survival |
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N. of Cases | Authors/Year | Sex/Age | CNS Tumor | Molecular Analysis | Surgery at Initial Diagnosis | Adjuvant Treatment | Progression/Recurrence | Outcome | ||
---|---|---|---|---|---|---|---|---|---|---|
Histology | Location | Glioma | Enchon-Droma | |||||||
1 | Becker et al. [7]. 1979 | n.s./26 | Oligoastrocytoma (grade II) | r. frontal | n.a. | n.a. | n.s. | n.s. | n.s. | n.s. |
2 | Rawlings et al. [34]. 1987 | M/29 | anaplastic astrocytoma (grade III) | multicentric (r. cerebellum, r. frontal) | n.a. | n.a. | biopsy | RT | n.s. | n.s. |
3 | Mellon et al. [25]. 1988 | M/34 | astrocytoma (grade II) | r. frontal | n.a. | n.a. | craniotomy | n.s. | n.s. | n.s. |
4 | Schwartz et al. [36]. 1987 | M/38 | malignant astrocytoma (grade III) | temporo- parietal | n.a. | n.a. | n.s. | n.s. | n.s. | dead |
5 | Patt et al. [30]. 1990 | M/24 | Astrocytoma (grade II) | brainstem | n.a. | n.a. | biopsy | n.s. | n.s. | n.s. |
6 | Bendel et al. [8]. 1991 | F/29 | high grade astrocytoma (grade III) | l. frontal | n.a. | n.a. | n.s. | n.s. | n.s. | n.s. |
7 | Chang et al. [12]. 1994 | M/23 | anaplastic astrocytoma (grade III) | Multicentric (both hemispheres) | n.a. | n.a. | biopsy | WBRT | no at 3 y | Alive at 3 y |
8 | Chang et al. [12]. 1994 | M/25 | oligodendroglioma | r. frontal | n.a. | n.a. | Craniotomy (STR) | RT | no at 8 mo. | Alive at 8 mo |
9 | Chang et al. [12]. 1994 | M/46 | oligoastrocytoma | Multicentric (both frontal lobes) | n.a. | n.a. | biopsy | RT | no at 4 mo. | Alive at 4 mo. |
10 | Hofman et al. [18]. 1998 | M/28 | Astrocytoma (grade II) | multicentric (l. temporal, brainstem) | n.a. | n.a. | biopsy | RT | no at 1 y | Alive at 1 y |
11 | Balcer et al. [5]. 1999 | F/23 | astrocytoma | pons | n.a. | n.a. | none | RT | n.s. | n.s. |
12 | Frappaz et al. [16]. 1999 | M/16 | astrocytoma | brainstem | n.a. | n.a. | none | RT | no at 7 mo. | Alive at 7 mo. |
13 | Van Nielen et al. [37]. 1999 | M/28 | Astrocytoma (grade II) | multicentric (l. temporal, brainstem) | n.a. | n.a. | biopsy | RT | n.s. | n.s. |
14 | Simsek et al. [38]. 2002 | F/7 | Astrocytoma (grade II) | r. frontal | n.a. | n.a. | n.s. | n.s. | n.s. | n.s. |
15 | Mahafza et al. [24]. 2004 | F/21 | Astrocytoma (grade II) | r. frontal, brainstem | n.a. | n.a. | biopsy | n.s. | n.s. | n.s. |
16 | Koc et al. [21]. 2006 | F/28 | anaplastic oligoastrocytoma | r. frontal | n.a. | n.a. | craniotomy | RT at recurrence | recurrence at 6 y, reoperation | alive at 10 y |
(grade III) | ||||||||||
17 | Ranger et al. [33]. 2009 | F/6 | glioblastoma | l. thalamus | n.a. | n.a. | biopsy | RT + CHT | progression | dead at 11 mo |
18 | Walid et al. [39]. 2008 | M/14 | anaplastic astrocytoma (grade III) | cerebellum | n.a. | n.a. | n.s. | n.s. | n.s. | n.s. |
19 | Hori et al. [19]. 2010 | M/19 | anaplastic astrocytoma (grade III) | Multicentric (brain, brainstem) | n.a. | n.a. | craniotomy | RT + CHT (TMZ) | stable | alive |
20 | Bathla et al. [6]. 2012 | M/16 | Astrocytoma (grade II) | multicentric (both frontal parietal lobes) | IDH1 R132H | n.a. | biopsy | CT and craniotomy at progression | progression to anaplastic astrocytoma (grade III) at 3 y, reoperation | Dead at 8 y |
21 | Pearce et al. [31]. 2012 | M/19 | Oligoastrocytoma (grade II) | multicentric (both hemispheres) | no mutation | n.a. | biopsy | no | progression at 9 mo. after biopsy, craniotomy | n.s. |
22 | Gajavelli et al. [17]. 2016 | F/55 | anaplastic astrocytoma (grade III) | multicentric (l. frontal, temporal, parietal) | IDH1 R132H | n.a. | craniotomy(STR) | no | stable at 3 y | alive at 3 y |
23 | Bonnet et al. [9]. 2016 | F/28 | Oligoastrocytoma (grade II) | multicentric | IDH1 R132H | n.a | biopsy | n.s. | n.s. | alive at 2.5 y |
(temporal, frontal) | ||||||||||
24 | Bonnet et al. [9]. 2016 | M/26 | n.s. | frontal | n.s. | n.a | biopsy | n.s. | n.s. | alive at 1 y |
25 | Bonnet et al. [9]. 2016 | F/30 | Oligodendroglioma (grade II) | multicentric (frontal, temporal | IDH1 R132H | n.a | biopsy | n.s. | n.s. | Alive at 4 y |
26 | Bonnet et al. [9]. 2016 | M/31 | Glioblastoma (grade IV) | multicentric (frontal, parietal | IDH1 R132H | n.a | biopsy | n.s. | n.s. | alive at 9 mo |
27 | Bonnet et al. [9]. 2016 | F/31 | Oligoastrocytoma (grade III) | frontal | IDH1 R132H | IDH1 R132H | biopsy | n.s. | n.s. | alive at 1.5 y |
28 | Achiha et al. [1]. 2017 | M/32 | oligodendroglioma | l. frontal | IDH1 R132H | IDH1 R132H | n.s. | n.s. | n.s. | n.s. |
29 | Al Rumeh et al. [2]. 2020 | F/23 | diffuse astrocytoma (grade II) | multicentric (l. frontal) | IDH1 R132C | n.a. | craniotomy | n.s. | n.s. | n.s. |
30 | Karabulut et al. [20]. 2021 | F/23 | diffuse midline glioma | pons | n.a. | n.a. | none | RT + CHT | stable | alive |
31 | Present case | M/33 | diffuse astrocytoma (grade II) | multicentric (both hemispheres) | IDH1 R132H | IDH1 R132H | biopsy | RT + CHT (TMZ) at initial diagnosis | progression at 48 mo. after biopsy, reoperation + RT | alive at 5 y |
Covariates | Overall Series |
---|---|
(31 Patients) | |
Age | 6–55 y |
(median 26 y) | |
Sex | 30 * |
F | 12 (40%) |
M | 18 (60%) |
Location | 31 * |
Single lesion | 16 (51%) |
supratentorial | 11 |
brainstem | 4 |
cerebellar | 1 |
Multicentric | 15 (49%) |
only supratentorial | 10 |
supra- and infratentorial | 5 |
Pathology | |
WHO grade | 24 * |
II | 13 |
III | 9 |
IV | 2 |
Histological type | 29 * |
astrocytic | 18 |
oligodendroglial | 3 |
oligo-astrocytic | 6 |
glioblastoma | 2 |
Molecular biology | 10 * gliomas |
Detection of IDH1 R132H mutation: | 3 * enchondromas |
glioma | 8/10 |
enchondroma | 3/3 |
Covariates | Overall Series |
---|---|
(31 Patients) | |
Surgery | 25 * |
biopsy | 16 |
craniotomy | 6 |
none | 3 |
Radiotherapy | 16 * |
at initial diagnosis | 12 |
at progression | 2 |
none | 2 |
Chemotherapy | 7 * |
at initial diagnosis | 3 |
at progression | 2 |
none | 2 |
Glioma evolution | 13 * |
Stable | 9 (from 3 to 36 mo.) |
Progression | 4 (from 9 to 72 mo.) |
Outcome | 18 * |
Alive | 15 (from 4 to 187 mo.) |
Dead | 3 (from 11 to 96 mo.) |
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Share and Cite
Corvino, S.; Mariniello, G.; Corazzelli, G.; Franca, R.A.; Del Basso De Caro, M.; Della Monica, R.; Chiariotti, L.; Maiuri, F. Brain Gliomas and Ollier Disease: Molecular Findings as Predictive Risk Factors? Cancers 2022, 14, 3464. https://doi.org/10.3390/cancers14143464
Corvino S, Mariniello G, Corazzelli G, Franca RA, Del Basso De Caro M, Della Monica R, Chiariotti L, Maiuri F. Brain Gliomas and Ollier Disease: Molecular Findings as Predictive Risk Factors? Cancers. 2022; 14(14):3464. https://doi.org/10.3390/cancers14143464
Chicago/Turabian StyleCorvino, Sergio, Giuseppe Mariniello, Giuseppe Corazzelli, Raduan Ahmed Franca, Marialaura Del Basso De Caro, Rosa Della Monica, Lorenzo Chiariotti, and Francesco Maiuri. 2022. "Brain Gliomas and Ollier Disease: Molecular Findings as Predictive Risk Factors?" Cancers 14, no. 14: 3464. https://doi.org/10.3390/cancers14143464