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Cancers
Volume 14
Issue 19
10.3390/cancers14194834
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Review
Peer-Review Record

Use of Personalized Biomarkers in Metastatic Colorectal Cancer and the Impact of AI

Cancers 2022, 14(19), 4834; https://doi.org/10.3390/cancers14194834
by Simona-Ruxandra Volovat 1,†, Iolanda Augustin 2, Daniela Zob 2, Diana Boboc 1,†, Florin Amurariti 1, Constantin Volovat 3,*, Cipriana Stefanescu 4,*, Cati Raluca Stolniceanu 4,†, Manuela Ciocoiu 5, Eduard Alexandru Dumitras 5,6, Mihai Danciu 7, Delia Gabriela Ciobanu Apostol 7, Vasile Drug 8,9, Sinziana Al Shurbaji 9, Lucia-Georgiana Coca 10, Florin Leon 11, Adrian Iftene 10 and Paul-Corneliu Herghelegiu 11
Reviewer 1:
Peter Gibbs
Reviewer 2:
Emmanuel Gabriel
Cancers 2022, 14(19), 4834; https://doi.org/10.3390/cancers14194834
Submission received: 10 July 2022 / Revised: 18 September 2022 / Accepted: 29 September 2022 / Published: 3 October 2022
(This article belongs to the Special Issue From Biobanking to Artificial Intelligence for Personalized Medicine of Cancer Therapy)

Round 1

Reviewer 1 Report

This paper provides a review of biomarkers in metastatic colorectal cancer and some discussion of AI.

Re biomarkers - Important markers are covered. There is some discussion of biomarkers in the adjuvant setting, eg., dMMR in early CRC, which should be deleted. The section on RNAs is very much out of proportion in terms of clinical relevance r.g., vs short paragraphs on RAS, BRAF and HER2. The sections on immunescore and epigenomics are also overly long given current relevance to clinical practice. 

Re AI - This is not really discussion of AI as a topic in metastatic CRC, rather the authors presenting some of their own original data. 

 

Author Response

Response about biomarkers :

We have deleted discussion about adjuvant settings in early CRC

We have extended the discussions with new relevant information about genomics biomarkers. Immunoscore and epigenomics represent in our opinion the emergent way for identifying new biomarkers in mCRC, with clinical relevance in the appropriate future.

Response about AI : We have completed with a review of AI in metastatic CRC

Author Response File: Author Response.docx

Reviewer 2 Report

This is a very comprehensive review paper. It is organized, highly detailed. It is one of the few times that I personally learned more about a topic, so I think it is very well done.

Only comment I would have is to add some more information/discussion about the clinical relevance/use of some of these items. There are papers in the literature for some of the less described topics that can be used as references. Examples:

Histone modification - PMID: 31055775

DNA methylation - PMID: 25580099

miRNA is covered very well, but mention of liquid biopsies in general would be appropriate for clinical relevance: examples - PMID: 35646657, PMID: 35264786, PMID: 35284120, PMID: 30128304, PMID: 29700206 

Author Response

1.We have added more information about Histone modification and DNA methylation

2.We have added more information about liquid biopsy.

Author Response File: Author Response.docx

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