Atypical Teratoid/Rhabdoid Tumor in Taiwan: A Nationwide, Population-Based Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Statistical Analysis
3. Results
3.1. Demographic and Clinical Characteristics
3.2. Distribution of Tumor Site and Treatment across Age Groups
3.3. Prognostic Factors
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Total (N = 47) * |
---|---|
Mean age at diagnosis (months) * Median age at diagnosis (months) | 66.87 (±109.32) 23.3 (12.5–87.9) |
Age group (months) | |
0–11 months | 11 (23.40%) |
12–35 months | 15 (31.91%) |
≥36 months | 21 (44.68%) |
Gender, Male | 29 (61.70%) |
Residence Location | |
Northern Taiwan | 21 (44.68%) |
Central Taiwan | 15 (31.91%) |
Southern Taiwan | 11 (23.40%) |
Tumor site | |
Supratentorial | 11 (23.40%) |
Infratentorial or Spine | 22 (46.81%) |
Unspecified nervous system or Others | 14 (29.79%) |
Treatment | |
Surgery or no treatment | 6 (12.77%) |
Chemotherapy (including SCT) | 12 (25.53%) |
RT | 5 (10.64%) |
RT + CT | 24 (51.06%) |
Diagnosis year | |
2008–2014 | 23 (48.94%) |
1999–2007 | 24 (51.06%) |
Tumor Site | Age < 3 Years (N = 26) | Age ≥ 3 Years (N = 21) | Total (N = 47) | p Value |
---|---|---|---|---|
Supratentorial | 3 (27%) | 8 (73%) | 11 | 0.082 a |
Infratentorial or Spine | 15 (68%) | 7 (32) | 22 | |
Unspecified nervous system or Others | 8 (57%) | 6 (43%) | 14 | |
Treatment | (N = 26) | (N = 21) | (N = 47) | |
Chemotherapy and/or radiotherapy | 20 (49%) | 21 (51%) | 41 | 0.026 b |
Surgery or No treatment | 6 (100%) | 0 (0%) | 6 |
Tumor Site | Chemotherapy Only (N = 12) | Radiotherapy with/ without Chemotherapy (N = 29) | Surgery or No Treatment (N = 6) | Total (N = 47) | p Value * | |
---|---|---|---|---|---|---|
Infratentorial or Spine | 7 (32%) | 12 (54%) | 3 (14%) | 22 | 0.698 | |
Supratentorial, Unspecified or Others | 5 (20%) | 17 (68%) | 3 (12%) | 25 |
Prognostic Factor | Univariate | Multivariate | ||||||
---|---|---|---|---|---|---|---|---|
HR | 95% CI | p Value * | HR | 95% CI | p Value * | |||
Age (months) | ||||||||
0–11 m | Reference | Reference | ||||||
12–23 m | 0.113 | (0.039–0.330) | <0.001 | 0.130 | (0.036–0.468) | 0.002 | ||
24–35 m | 0.379 | (0.082–1.754) | 0.214 | 1.769 | (0.175–17.852) | 0.629 | ||
≥36 m | 0.078 | (0.028–0.216) | <0.001 | 0.356 | (0.066–1.929) | 0.231 | ||
Gender | ||||||||
Female | Reference | Reference | ||||||
Male | 0.942 | (0.481–1.844) | 0.862 | 1.012 | (0.430–2.379) | 0.979 | ||
Tumor site | ||||||||
Supratentorial | Reference | Reference | ||||||
Infratentorial or Spine | 3.121 | (1.146–8.497) | 0.026 | 3.234 | (1.049–9.973) | 0.041 | ||
Unspecified nervous system or Others | 3.261 | (1.139–9.337) | 0.028 | 3.505 | (1.121–10.955) | 0.031 | ||
Treatment | ||||||||
Surgery or No treatment | Reference | Reference | ||||||
Chemotherapy (including SCT) | 0.079 | (0.021–0.305) | <0.001 | 0.013 | (0.002–0.097) | <0.001 | ||
Radiotherapy | 0.011 | (0.002–0.063) | <0.001 | 0.002 | (0.000–0.025) | <0.001 | ||
Radiotherapy + Chemotherapy | 0.016 | (0.004–0.066) | <0.001 | 0.003 | (0.000–0.031) | <0.001 | ||
Diagnosis year | ||||||||
1999–2007 | Reference | Reference | ||||||
2008–2014 | 1.439 | (0.725–2.856) | 0.298 | 1.316 | (0.477–3.632) | 0.596 |
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Liu, Y.-L.; Tsai, M.-L.; Chen, C.-I.; Yar, N.; Tsai, C.-W.; Lee, H.-L.; Kuo, C.-C.; Ho, W.-L.; Hsieh, K.L.-C.; Tseng, S.-H.; et al. Atypical Teratoid/Rhabdoid Tumor in Taiwan: A Nationwide, Population-Based Study. Cancers 2022, 14, 668. https://doi.org/10.3390/cancers14030668
Liu Y-L, Tsai M-L, Chen C-I, Yar N, Tsai C-W, Lee H-L, Kuo C-C, Ho W-L, Hsieh KL-C, Tseng S-H, et al. Atypical Teratoid/Rhabdoid Tumor in Taiwan: A Nationwide, Population-Based Study. Cancers. 2022; 14(3):668. https://doi.org/10.3390/cancers14030668
Chicago/Turabian StyleLiu, Yen-Lin, Min-Lan Tsai, Chang-I Chen, Noi Yar, Ching-Wen Tsai, Hsin-Lun Lee, Chia-Chun Kuo, Wan-Ling Ho, Kevin Li-Chun Hsieh, Sung-Hui Tseng, and et al. 2022. "Atypical Teratoid/Rhabdoid Tumor in Taiwan: A Nationwide, Population-Based Study" Cancers 14, no. 3: 668. https://doi.org/10.3390/cancers14030668