The Pseudokinase TRIB1 in Immune Cells and Associated Disorders
Abstract
:Simple Summary
Abstract
1. Introduction
2. Overview of the TRIB1 Gene and Protein
3. A Role for TRIB1 in Physiopathology
Disease | Description | Reference |
---|---|---|
Renal transplantation | Increased TRIB1 expression in PBMCs and biopsies from patients with CAMR | Ashton-Chess et al. 2008 [26] |
Human Immunodeficiency Virus (HIV) | Overexpression of TRIB1 in PBMCs from HIV patients | Rome et al. 2020 [30] |
Systemic Lupus Erythematosus (SLE) | Increased expression of TRIB1 in B cells from SLE patients | Garaud et al. 2011; Simoni et al. 2018 [29,43] |
Inflammatory Bowel Disease (IBD) | TRIB1 SNP associated with IBD in patients | Liu et al. 2015; Jostins et al. 2012 [31,32] |
Eczema | TRIB1 SNP associated with eczema | Grosche et al. 2021 [33] |
Coronary Artery Disease | TRIB1 locus association with plasma triglycerides and coronary artery disease | Burkhardt et al. 2010; Douvris et al. 2014 [36,44] |
Acute Myeloid Leukemia (AML) | TRIB1 induces inappropriate C/EBPα protein degradation. TRIB1 cooperates with BCL11A which represses several PU.1 target genes | Yokoyama et al. 2011; Yoshida et al. 2013; Yoshino et al. 2021; Sunami et al. 2002 [23,45,46,47] |
Multiple Myeloma (MM) | Higher TRIB1 expression in bone marrow mononuclear cells from MM patients favoring M2 macrophage polarization | Chen et al. 2020 [48] |
Hepatocellular Carcinoma (HCC) | TRIB1 promotes (HCC) tumorigenesis and invasiveness via the downregulation of p53 with the possible involvement of the β-catenin signaling pathway | Ye et al. 2017 [49] |
Colorectal cancer | TRIB1 is overexpressed, similarly to MYC. TRIB1 promotes upregulation of MMP-2 through the activation of FAK/Src and ERK pathways | Y. Wang et al. 2017; Briffa et al. 2015; Camps et al. 2009 [25,50,51] |
Prostate cancer | TRIB1 amplification and over-expression are associated with proliferation, cell survival, and metastasis. TRIB1 regulates the GRP78 endoplasmic reticulum chaperone protein, regulating Akt activation | Mashima et al. 2014; Shahrouzi et al. 2020; Moya et al. 2018 [24,52,53] |
Non-small cell lung cancer (NSCLC) | Cisplatin treatment resulted in C/EBPβ-dependent increasing of TRIB1 which cooperates with HDAC1 to downregulate p53 activation. TRIB1 may be involved in chemotherapy resistance TRIB1 is modulated by the activation of the PI3K/AKT pathway, specifically by PIK3CA, in lung epithelial cells | L. Wang et al. 2017; De Marco et al. 2017 [54,55] |
Glioma | TRIB1 binds to HDAC1 to inhibit p53 expression in glioma cells and participate in radioresistance | Tang et al. 2015 [56] |
Several Amplicon 8q24 Associated Cancers | TRIB1 gene located at the same chromosomal locus 8q24.13 in close proximity to MYC; potentially co-amplified alongside | Röthlisberger et al. 2007 [21]. |
4. Evidence of TRIB1 Function in Immune Cell Subsets
4.1. TRIB1 in Macrophages
4.2. TRIB1 in CD4+ T Lymphocytes
4.3. TRIB1 in Regulatory T Cells
4.4. TRIB1 in B Lymphocytes
4.5. TRIB1 in Eosinophils and Neutrophils
5. TRIB1 Cell Signaling and Protein Binding Partners
5.1. TRIB1-FOXP3 Protein Interaction
5.2. TRIB1-COP1 Regulation of the C/EBPα Protein
5.3. TRIB1-MEK1 in ERK/MAPK Signaling
5.4. TRIB1 Implication in NF/KB Pathway Activity
5.5. Other TRIB1 Protein Binding Partners
6. Regulation of TRIB1
6.1. Transcriptional Regulation of TRIB1
6.2. Posttranslational Modification of TRIB1
6.3. Cellular Colocalization of TRIB1
7. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Danger, R.; Feseha, Y.; Brouard, S. The Pseudokinase TRIB1 in Immune Cells and Associated Disorders. Cancers 2022, 14, 1011. https://doi.org/10.3390/cancers14041011
Danger R, Feseha Y, Brouard S. The Pseudokinase TRIB1 in Immune Cells and Associated Disorders. Cancers. 2022; 14(4):1011. https://doi.org/10.3390/cancers14041011
Chicago/Turabian StyleDanger, Richard, Yodit Feseha, and Sophie Brouard. 2022. "The Pseudokinase TRIB1 in Immune Cells and Associated Disorders" Cancers 14, no. 4: 1011. https://doi.org/10.3390/cancers14041011