A Novel Framework for the Optimization of Simultaneous ThermoBrachyTherapy
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Overview of Optimization Framework
2.2. Patient Anatomy Modeling
2.3. TBT Applicator Modeling, Positioning, and E-Field Calculation
2.4. Temperature Calculation and Superpositioning
2.5. HDR-BT Treatment Plan and Dose Calculation
2.6. Thermoradiobiological Modeling
2.7. Thermoradiobiological Objective Function and Optimization Algorithm
2.8. Temperature Superpositioning Validation
2.9. Implementation on Patient Data
3. Results
3.1. Temperature Superpositioning Validation
3.2. Thermal Radiosensitization
3.3. Treatment Planning Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Tissue | ρ (kg/m3) | σ @27 MHz (S/m) | εr @27 MHz | c (J/kg/K) | k (W/m/K) | ω (ml/kg/min) |
---|---|---|---|---|---|---|
Applicator Dielectric [38,39] | 1289 | 1 × 10−5 | 2.4 | 712 | 0.084 | - |
Air [37] | 1.164 | 0 | 1.0 | 1004 | 0.0273 | - |
Muscle [37] | 1090.4 | 0.654 | 95.8 | 3421 | 0.495 | 40 |
Fat [37] | 911 | 0.061 | 17.9 | 2348 | 0.211 | 33 |
Bone [37] | 1908 | 0.052 | 21.8 | 1313 | 0.320 | 10 |
Prostate [37] | 1045 | 0.838 | 120.1 | 3760 | 0.512 | 394 |
Rectum [37] | 1045 | 0.654 | 95.8 | 3801 | 0.557 | 0 |
Urethra [37] | 1102 | 0.375 | 88.8 | 3306 | 0.462 | 394 |
Bladder [37] | 1086 | 0.276 | 31.5 | 3581 | 0.522 | 78 |
Tissue | Criterion | Aim | Type |
---|---|---|---|
Prostate | V100% | ≥95% | Objective |
V150% | <30% | Soft Constraint | |
V200% | <8% | Soft Constraint | |
Urethra | D0.1cc | <115% | Hard Constraint |
Rectum | D1cc | <75% | Hard Constraint |
Bladder | D1cc | <75% | Soft Constraint |
Constraints | Tissue | Criterion (Ci) | Limit (Li) | Type |
---|---|---|---|---|
Prostate | V100% | Value of BT-only | High pass | |
Urethra | D0.1cc | Value of BT-only | Low pass | |
Rectum | D1cc | Value of BT-only | Low pass | |
Bladder | D1cc | Value of BT-only | Low pass | |
All | Tmax | 47.5 °C | Low pass | |
Objectives | Tissue | Criterion (Oj) | Goal (Gj) | Weight (wi) |
Urethra | D0.1cc | 0 | 1 | |
Rectum | D1cc | 0 | 1 | |
Prostate | V150% | 30% of volume | 0.01 |
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Androulakis, I.; Mestrom, R.M.C.; Christianen, M.E.M.C.; Kolkman-Deurloo, I.-K.K.; van Rhoon, G.C. A Novel Framework for the Optimization of Simultaneous ThermoBrachyTherapy. Cancers 2022, 14, 1425. https://doi.org/10.3390/cancers14061425
Androulakis I, Mestrom RMC, Christianen MEMC, Kolkman-Deurloo I-KK, van Rhoon GC. A Novel Framework for the Optimization of Simultaneous ThermoBrachyTherapy. Cancers. 2022; 14(6):1425. https://doi.org/10.3390/cancers14061425
Chicago/Turabian StyleAndroulakis, Ioannis, Rob M. C. Mestrom, Miranda E. M. C. Christianen, Inger-Karine K. Kolkman-Deurloo, and Gerard C. van Rhoon. 2022. "A Novel Framework for the Optimization of Simultaneous ThermoBrachyTherapy" Cancers 14, no. 6: 1425. https://doi.org/10.3390/cancers14061425