Long Non-Coding RNAs as Potential Regulators of EMT-Related Transcription Factors in Colorectal Cancer—A Systematic Review and Bioinformatics Analysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Systematic Literature Review
2.1.1. Study Design
2.1.2. Inclusion and Exclusion Criteria
2.1.3. Data Extraction and Outcomes
2.2. Bioinformatics Analysis
3. Results
3.1. LncRNAs Regulating a Single EMT-TF
3.2. ZEB1
3.3. SNAI1
3.4. TWIST1
3.5. SNAI2
3.6. LncRNAs Regulating Multiple EMT-TFs
3.7. ZEB1 and ZEB2
3.8. ZEB1 and SNAI1
3.9. ZEB1, ZEB2 and SNAI1
3.10. ZEB1, SNAI1 and SNAI2
3.11. ZEB2, SNAI1 and SNAI2
3.12. ZEB2 and SNAI2
3.13. ZEB2, SNAI1 and TWIST1
3.14. SNAI1 and SNAI2
3.15. SNAI1 and TWIST1
3.16. SNAI1, SNAI2 and TWIST1
3.17. Bioinformatics Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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lncRNA | TF | Patient Characteristics | In Vitro | In Vivo | Ref. | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OS | T | N | M | LVI | Prolif. | Migr. | Invas. | Met. | CSC | Morph. | Tumor Size | Met. | |||
AC010789.1 | ZEB1 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | [32] | ||||||
AFAP1-AS1 | ZEB1 | ↓ | ↑ | ↑ | / | / | [33] | ||||||||
AK000053 | ZEB1 | ↓ | ↑ | ↑ | ↑ | yes | ↑ | ↑ | [34] | ||||||
ATB | ZEB1 | ↓ | ↑ | ↑ | ↑ | ↑ | / | / | [35] | ||||||
DUXAP8 | ZEB1 | ↑ | ↑ | ↑ | ↑ | [36] | |||||||||
HCP5 | ZEB1 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | / | / | [37] | |||||
KCNQ1OT1 | ZEB1 | ↓ | ↑ | ↑ | / | / | [38] | ||||||||
LINC00460 | ZEB1 | / | / | / | / | / | ↑ | ↑ | / | / | [39] | ||||
LINC01413 | ZEB1 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | [40] | ||||
N-BLR | ZEB1 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | [41] | ||||||
RP11 | ZEB1 | ↑ | ↑ | ↑ | no | ↑ | ↑ | yes | no | ↑ | [42] | ||||
ZEB1-AS1 | ZEB1 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | / | / | [43,44] | ||||
ZFAS1 | ZEB1 | ↓ | ↑ | ↑ | ↑ | ↑ | [45] | ||||||||
GNAT1 | SNAI1 | ↑ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | [46] | ||||
LDLRAD4-AS1 | SNAI1 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | [47] | |||||
SATB2-AS1 | SNAI1 | ↑ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ | [48] | ||||
TRERNA1 | SNAI1 | ↓ | ↑ | ↑ | ↑ | no | ↑ | ↑ | ↑ | / | / | [49] | |||
GAPLINC | SNAI2 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | [50] | |||||||
SNHG15 | SNAI2 | ↓ | no | ↑ | ↑ | [51] | |||||||||
XLOC_010588 | SNAI2 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | / | / | [52] | ||||
AK027294 | TWIST1 | / | / | / | / | / | ↑ | ↑ | / | / | [53] | ||||
CHRF | TWIST1 | ↓ | ↑ | ↑ | ↑ | ↑ | yes | no | ↑ | [54] | |||||
LINC00467 | TWIST1 | ↓ | ↑ | ↑ | ↑ | / | / | [55] | |||||||
LINC00941 | TWIST1 | ↓ | ↑ | ↑ | ↑ | yes | ↑ | [56] | |||||||
SNHG11 | TWIST1 | / | / | / | / | / | ↑ | ↑ | ↑ | [57] |
LncRNA | ZEB1 | ZEB2 | SNAI1 | SNAI2 | TWIST1 |
---|---|---|---|---|---|
DLEU2 | x | x | |||
LINC01296 | x | x | |||
VIM-AS1 | x | x | |||
ZEB2-AS1 | x | x | |||
H19 | x | x | x | ||
SNHG6 | x | x | x | ||
XIST | x | x | x | ||
B3GALT5-AS1 | x | x | |||
TUG1 | x | x | x | ||
UICLM | x | x | x | ||
MAPKAPK5-AS1 | x | x | |||
HOTAIR | x | x | |||
CTD-903 | x | x | |||
PANDAR | x | x | |||
HOXA11-AS | x | x | x | ||
MIR4435-2HG | x | x | x |
LncRNA | TFs | Patient Characteristics | In Vitro | In Vivo | Ref. | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OS | T | N | M | LVI | Prolif. | Migr. | Invas. | Met. | CSC | Morph. | Tumor Size | Met. | |||
B3GALT5-AS1 | ZEB2 SNAI2 | ↑ | ↓ | ↓ | ↓ | ↓ | ↓ | [58] | |||||||
CTD-903 | SNAI1 TWIST1 | ↑ | no | no | no | ↓ | ↓ | ↓ | yes | / | / | [59] | |||
DLEU2 | ZEB1 ZEB2 | ↓ | ↑ | ↑ | ↑ | / | / | [60] | |||||||
H19 | ZEB1 ZEB2 | / | / | / | / | / | ↑ | ↑ | yes | ↑ | [61] | ||||
H19 | ZEB1 | ↓ | ↑ | ↑ | ↑ | ↑ | / | / | / | / | / | / | / | / | [62] |
H19 | SNAI1 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | / | / | [63,64] | ||
HOTAIR | SNAI1 SNAI2 | / | / | / | / | / | ↑ | ↑ | ↑ | ↑ | [65] | ||||
HOXA11-AS | SNAI1 SNAI2 TWIST1 | ↓ | ↑ | ↑ | ↑ | / | / | [66] | |||||||
LINC01296 | ZEB1 ZEB2 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | / | / | [67] | |||||
MAPKAPK5-AS1 | SNAI1 SNAI2 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | [68] | |||||
MIR4435-2HG | SNAI1 SNAI2 TWIST1 | ↓ | ↑ | ↑ | ↑ | no | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | [69] | ||
PANDAR | SNAI1 TWIST1 | ↓ | ↑ | ↑ | no | ↑ | ↑ | ↑ | / | / | [70] | ||||
SNHG6 | ZEB1 SNAI1 SNAI2 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | [71] | |||||||
SNHG6 | SNAI1 | / | / | / | / | / | ↑ | ↑ | / | / | [72] | ||||
TUG1 | ZEB2 SNAI1 | / | / | / | / | / | ↑ | ↑ | / | / | [73] | ||||
TUG1 | TWIST1 | / | / | / | / | / | no | ↑ | ↑ | ↑ | [74] | ||||
UICLM | ZEB2 SNAI1 SNAI2 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | [75] | ||||
VIM-AS1 | ZEB1 SNAI1 | ↓ | no | ↑ | ↑ | ↑ | ↑ | yes | / | / | [76] | ||||
ZEB2-AS1 | ZEB1 SNAI1 | ↓ | ↑ | ↑ | / | / | [77] | ||||||||
XIST | ZEB1 SNAI1 SNAI2 | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | yes | ↑ | ↑ | [26] |
LncRNA | ZEB1 | ZEB2 | SNAI2 |
---|---|---|---|
AC106786.1 | ↑↑ | ↑↑ | |
AC112721.2 | ↑↑ | ↑↑ | |
ADAMTS9-AS1 | ↑↑ | ||
ADAMTS9-AS2 | ↑↑↑ | ||
DNM3OS | ↑↑ | ↑↑ | ↑↑ |
FNDC1-IT1 | ↑↑ | ||
LINC00578 | ↑↑ | ↑↑ | |
MAGI2-AS3 | ↑↑↑ | ↑↑↑ | ↑↑ |
PIK3R6 | ↑↑ | ||
TP73-AS1 | ↑↑ | ↑↑ | |
VCAN-AS1 | ↑↑ | ||
ZNF154 | ↑↑ | ↑↑ |
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Pavlič, A.; Hauptman, N.; Boštjančič, E.; Zidar, N. Long Non-Coding RNAs as Potential Regulators of EMT-Related Transcription Factors in Colorectal Cancer—A Systematic Review and Bioinformatics Analysis. Cancers 2022, 14, 2280. https://doi.org/10.3390/cancers14092280
Pavlič A, Hauptman N, Boštjančič E, Zidar N. Long Non-Coding RNAs as Potential Regulators of EMT-Related Transcription Factors in Colorectal Cancer—A Systematic Review and Bioinformatics Analysis. Cancers. 2022; 14(9):2280. https://doi.org/10.3390/cancers14092280
Chicago/Turabian StylePavlič, Ana, Nina Hauptman, Emanuela Boštjančič, and Nina Zidar. 2022. "Long Non-Coding RNAs as Potential Regulators of EMT-Related Transcription Factors in Colorectal Cancer—A Systematic Review and Bioinformatics Analysis" Cancers 14, no. 9: 2280. https://doi.org/10.3390/cancers14092280