The Judicious Use of Stereotactic Ablative Radiotherapy in the Primary Management of Localized Renal Cell Carcinoma
Abstract
:Simple Summary
Abstract
1. Introduction
2. SABR Rationale and Patient Selection in Localized RCC
2.1. Overview of Staging and Management Options
2.2. Societal Guidelines and Rationale for SABR in Localized RCC
2.3. Patient Evaluation Prior to SABR
3. Treatment of Primary RCC with SABR
3.1. Selection of Treatment Prescription and Normal Tissue Constraints
3.2. Informed Consent
3.3. Treatment Setup, Design, and Delivery
3.4. Treatment Response Assessment
4. Conclusions and Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Organ | One Fraction | Three Fractions | Five Fractions |
---|---|---|---|
D0.035cc < 22 Gy a or 26 Gy b | D0.035cc < 30 Gy a,b | D0.035cc < 35 Gy a or < 29 Gy d | |
Small bowel/duodenum | D5cc < 17.4 Gy a or < 22.5 Gy b | D5cc < 22.5 Gy a or D30cc < 12.5 Gy b | D5cc < 26.5 Gy a |
Maximum dose to full bowel wall circumference ≤ 12.5 Gy b | |||
Large bowel | D0.035cc < 31 Gy a or D1.5cc ALARA, aim for < 26 Gy b | D0.035cc < 45 Gya or D1.5cc ALARA, aim for <42 Gy b | D0.035cc <52.5 Gy a or <29 Gy d |
Stomach | D0.035cc < 22 Gy a or D1.5cc < 15.4 Gy b | D0.035cc < 30 Gy a,b | D0.035cc <35 Gy a or <29 Gy d |
Liver | D700cc < 11.6 Gy a | D700cc < 15 Gy b or <17.7 Gy a | D700cc <19.6 Gy a or D50% < 25 Gy d |
Ipsilateral kidney–ITV | ALARA, minimize volume of >50% IDL b | ALARA, minimize volume of >50% IDL b | D60% < 15 Gy d |
Contralateral kidney | V10Gy ≤ 33% b | V10Gy ≤ 33% b | D100% < 11 Gy d |
Ureter | D0.035 cm3 < 35 Gy a | D0.035 cm3 < 40 Gy a | D0.035 cm3 < 45 Gy a |
Spinal canal | D0.035 cm3 < 12 Gy c | D0.035 cm3 < 18 Gy c | D0.035 cm3 < 27.5 Gy c |
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Share and Cite
Barbour, A.B.; Kirste, S.; Grosu, A.-L.; Siva, S.; Louie, A.V.; Onishi, H.; Swaminath, A.; Teh, B.S.; Psutka, S.P.; Weg, E.S.; et al. The Judicious Use of Stereotactic Ablative Radiotherapy in the Primary Management of Localized Renal Cell Carcinoma. Cancers 2023, 15, 3672. https://doi.org/10.3390/cancers15143672
Barbour AB, Kirste S, Grosu A-L, Siva S, Louie AV, Onishi H, Swaminath A, Teh BS, Psutka SP, Weg ES, et al. The Judicious Use of Stereotactic Ablative Radiotherapy in the Primary Management of Localized Renal Cell Carcinoma. Cancers. 2023; 15(14):3672. https://doi.org/10.3390/cancers15143672
Chicago/Turabian StyleBarbour, Andrew B., Simon Kirste, Anca-Liga Grosu, Shankar Siva, Alexander V. Louie, Hiroshi Onishi, Anand Swaminath, Bin S. Teh, Sarah P. Psutka, Emily S. Weg, and et al. 2023. "The Judicious Use of Stereotactic Ablative Radiotherapy in the Primary Management of Localized Renal Cell Carcinoma" Cancers 15, no. 14: 3672. https://doi.org/10.3390/cancers15143672
APA StyleBarbour, A. B., Kirste, S., Grosu, A. -L., Siva, S., Louie, A. V., Onishi, H., Swaminath, A., Teh, B. S., Psutka, S. P., Weg, E. S., Chen, J. J., Zeng, J., Gore, J. L., Hall, E., Liao, J. J., Correa, R. J. M., & Lo, S. S. (2023). The Judicious Use of Stereotactic Ablative Radiotherapy in the Primary Management of Localized Renal Cell Carcinoma. Cancers, 15(14), 3672. https://doi.org/10.3390/cancers15143672