A Comprehensive Review of Prognostic Factors in Patients with Gastric Adenocarcinoma
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
3.1. Predictive Tools of Long-Term Prognosis in Gastric Cancer Patients
3.1.1. The TNM/UICC Staging System
3.1.2. Alternative Prognostic Tools beyond the TNM
3.2. Biological Features of Gastric Cancer and Their Impact on Long-Term Prognosis
3.2.1. Ethnicity
3.2.2. Sex-Related Differences
3.2.3. Histological Subtype
3.2.4. Tumor Micro-Environment, Genetic Phenotypes
3.3. Improvement of Gastric Cancer Prognosis over Time; Evolution of Treatment Strategies for Resectable Disease
3.3.1. Surgery
3.3.2. Systemic Chemotherapy
3.3.3. External Beam Radiation
3.3.4. Advanced Disease, Peritoneal Carcinomatosis
3.3.5. Targeted Therapies
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Tumor Stage (8th TNM ed., [8]) | American NCDB Registry [10] | 5-Year OS (%) | Median Survival (95%CI) | European Monocentric Registry [11] | 5-Year OS (%) | American SEER Registry [12] | 5-Year OS (%) | Asian Monocentric Registry [13] | 5-Year OS (%) |
---|---|---|---|---|---|---|---|---|---|
IA | 1501 | 81.0 | 129.8 (129.8–133) | 2170 | 77.5 | 618 | 94.8 | ||
IB | 1095 | 68.5 | 112.8 (100.0-NA) | 74 | 69.8 | 1065 | 63.3 | 313 | 89 |
IIA | 1245 | 59.3 | 91.6 (79.1–103.1) | 1241 | 50.8 | 345 | 84.6 | ||
IIB | 1432 | 46.4 | 50.5 (46.6–58.2) | 60 | 51.6 | 1404 | 35.3 | 455 | 76.1 |
IIIA | 2310 | 30.5 | 25.0 (23.3–26.9) | 30 | 25.9 | 2113 | 20.5 | 791 | 60.3 |
IIIB | 1896 | 20.1 | 17.4 (16.4–18.7) | 32 | 32.7 | 1466 | 13.5 | 920 | 40.9 |
IIIC | 1067 | 8.3 | 11.8 (10.9–12.7) | 28 | 9.8 | 735 | 5.3 | 825 | 27.5 |
IV | 1449 | 5.6 | 8.9 (8.3–9.7) | 17 | 4.5 | 0 | NA | 0 | NA |
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Mantziari, S.; St Amour, P.; Abboretti, F.; Teixeira-Farinha, H.; Gaspar Figueiredo, S.; Gronnier, C.; Schizas, D.; Demartines, N.; Schäfer, M. A Comprehensive Review of Prognostic Factors in Patients with Gastric Adenocarcinoma. Cancers 2023, 15, 1628. https://doi.org/10.3390/cancers15051628
Mantziari S, St Amour P, Abboretti F, Teixeira-Farinha H, Gaspar Figueiredo S, Gronnier C, Schizas D, Demartines N, Schäfer M. A Comprehensive Review of Prognostic Factors in Patients with Gastric Adenocarcinoma. Cancers. 2023; 15(5):1628. https://doi.org/10.3390/cancers15051628
Chicago/Turabian StyleMantziari, Styliani, Penelope St Amour, Francesco Abboretti, Hugo Teixeira-Farinha, Sergio Gaspar Figueiredo, Caroline Gronnier, Dimitrios Schizas, Nicolas Demartines, and Markus Schäfer. 2023. "A Comprehensive Review of Prognostic Factors in Patients with Gastric Adenocarcinoma" Cancers 15, no. 5: 1628. https://doi.org/10.3390/cancers15051628