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Open AccessArticle
Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2)
by
Zsolt Abonyi-Tóth
Zsolt Abonyi-Tóth 1,2
,
György Rokszin
György Rokszin 1
,
Gábor Sütő
Gábor Sütő 3,
Ibolya Fábián
Ibolya Fábián 1,2,
Zoltán Kiss
Zoltán Kiss 3,
György Jermendy
György Jermendy 4
,
Péter Kempler
Péter Kempler 5,
Csaba Lengyel
Csaba Lengyel 6,
István Wittmann
István Wittmann 3,*
and
Gergő A. Molnár
Gergő A. Molnár 3
1
RxTarget Ltd., 5000 Szolnok, Hungary
2
Department of Biostatistics, University of Veterinary Medicine, 1078 Budapest, Hungary
3
Second Department of Medicine and Nephrology-Diabetes Centre, University of Pécs Medical School, 7624 Pécs, Hungary
4
Department of Internal Medicine, Bajcsy-Zsilinszky Hospital, 1106 Budapest, Hungary
5
Department of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary
6
Department of Internal Medicine, University of Szeged, 6720 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Submission received: 17 May 2024
/
Revised: 27 June 2024
/
Accepted: 28 June 2024
/
Published: 29 June 2024
Simple Summary
This study aimed to determine the risk and rate of development of overall and site-specific cancer in patients with type 2 diabetes mellitus compared with non-diabetic individuals. In this retrospective cohort study, excess incidence of cancer was found in patients with type 2 diabetes mellitus. While the incidence of cancer decreased in non-diabetic controls between 2015 and 2019 in most age groups and for several cancer sites, this decrease was less significant among patients with type 2 diabetes mellitus. Therefore, the results of this study demonstrate that the presence of type 2 diabetes mellitus leads to a higher incidence of cancer.
Abstract
(1) Background: Among the chronic complications of type 2 diabetes mellitus, cancer has become the leading cause of death in several countries. Our objective was to determine whether prevalent type 2 diabetes mellitus is associated with a higher incidence of cancer. (2) Methods: This study comprised a nationwide analysis conducted in Hungary. The study population was divided into two groups: a type 2 diabetes mellitus group vs. a non-diabetic group. The primary outcome was the risk related to overall cancer incidence; a key secondary outcome was the overall incidence of cancer in distinct study years; and a further outcome was the annual percent changes. (3) Results: The odds ratio related to the overall incidence of cancer was 2.50 (95% confidence interval: 2.46–2.55, p < 0.0001) in patients with diabetes as related to non-diabetic controls. The odds ratio was higher in males than in females [ORmales: 2.76 (2.70–2.82) vs. ORfemales: 2.27 (2.22–2.33), p < 0.05 for male-to-female comparison]. The annual cancer incidence rate declined in non-diabetic controls, but not in patients with diabetes [−1.79% (−2.07–−1.52%), p < 0.0001] vs. −0.50% (−1.12–+0.10%), p = 0.0991]. Several types of cancer showed a decreasing tendency in non-diabetic controls, but not in patients with type 2 diabetes. (4) Conclusions: Type 2 diabetes is associated with a higher risk of cancer. While the cancer incidence decreased for non-diabetic individuals with time, it remained unchanged in patients with T2DM.
Share and Cite
MDPI and ACS Style
Abonyi-Tóth, Z.; Rokszin, G.; Sütő, G.; Fábián, I.; Kiss, Z.; Jermendy, G.; Kempler, P.; Lengyel, C.; Wittmann, I.; Molnár, G.A.
Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2). Cancers 2024, 16, 2414.
https://doi.org/10.3390/cancers16132414
AMA Style
Abonyi-Tóth Z, Rokszin G, Sütő G, Fábián I, Kiss Z, Jermendy G, Kempler P, Lengyel C, Wittmann I, Molnár GA.
Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2). Cancers. 2024; 16(13):2414.
https://doi.org/10.3390/cancers16132414
Chicago/Turabian Style
Abonyi-Tóth, Zsolt, György Rokszin, Gábor Sütő, Ibolya Fábián, Zoltán Kiss, György Jermendy, Péter Kempler, Csaba Lengyel, István Wittmann, and Gergő A. Molnár.
2024. "Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2)" Cancers 16, no. 13: 2414.
https://doi.org/10.3390/cancers16132414
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