Efficacy and Safety of Cryoablation in Barrett’s Esophagus and Comparison with Radiofrequency Ablation: A Meta-Analysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Inclusion and Exclusion Criteria
2.2. Search Strategy
2.3. Data Extraction and Quality Assessment
2.4. Outcomes
2.5. Statistical Analysis
3. Results
3.1. Characteristics of Included Studies
3.2. Quality Assessment
3.3. Primary Outcome
3.4. Secondary Outcomes
3.5. Subgroup Analysis
3.6. Sensitivity Analysis
3.7. Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Patients | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
First Author | Year | Country | Study Design | Recruitment Period | Cryoablation | RFA | Type of Device | Male | Age | Mean Maximum Length | LGD | HGD/OC | Sessions | Prior EMR | |
1 | Snady | 2023 | USA | Prospective | n/a | 62 | - | Spray catheter | 32 | 62.2 | 3 | 16 | 11 | 2.8 | |
2 | Agarwal | 2022 | USA | Retrospective | 2014–2020 | 85 | 226 | Cryoballoon | 148 | 67.1 | 3.6 | 32 | 53 | - | 51 |
3 | Overwater | 2021 | Netherlands | Prospective | 2018–2020 | 25 | - | Cryoballoon | 23 | 69 | 3 | 10 | 15 | - | 14 |
4 | Canto | 2020 | USA | Multicenter prospective | 2016–2018 | 94 | - | Cryoballoon | 76 | 65 | 3.1 | 19 | 73 | 2 | 40 |
5 | van Munster | 2019 | Netherlands | Prospective | 2017–2018 | 25 | - | Cryoballoon | 19 | 67 | 3 | 19 | 5 | - | 5 |
6 | van Munster | 2018 | Netherlands | Prospective | 2016–2017 | 20 | 26 | Cryoballoon | 38 | 66 | 2 | 9 | 11 | - | 10 |
7 | Canto | 2018 | USA | Prospective | 2015–2016 | 41 | - | Cryoballoon | 34 | 65.7 | 3.9 | 13 | 28 | 3 | 14 |
8 | Künzli | 2016 | Netherlands | Prospective | 2015–2016 | 30 | - | Cryoballoon | 26 | 66 | 2 | 14 | 16 | - | 15 |
9 | Schölvinck | 2015 | Netherlands | Multicenter prospective | 2012–2014 | 39 | - | Cryoballoon | 35 | 66 | 5 | 9 | 20 | - | 12 |
10 | Frederiks | 2022 | Multicenter | Retrospective | 2019–2020 | 56 | - | Cryoballoon | 49 | 67–68 | 2 | 16 | 40 | 7.9 | |
11 | Eluri | 2024 | USA | Multicenter prospective | 2013–2022 | 138 | - | Spray catheter | 106 | 69 | 3.6 | 33 | 105 | - | 62 |
12 | Thota | 2018 | USA | Prospective | 2006–2011 | 81 | 73 | Spray catheter | 131 | 69.8 | 5.2 | 13 | 60 | 3 | 35 |
13 | Fasullo | 2021 | USA | Retrospective | 2014–2020 | 62 | 100 | Spray catheter | 143 | 67.1 | 4.7 | 36 | 26 | 4.8 | |
14 | Genere | 2022 | USA | Retrospective | 2005–2020 | 23 | 23 | Spray catheter | 33 | 68 | 8 | 7 | 16 | 4 | 13 |
15 | Dumot | 2009 | USA | Prospective | 2005–2008 | 30 | - | Spray catheter | 21 | 69.7 | 6.1 | - | 30 | 5 | 1 |
16 | Shaheen | 2011 | USA | Multicenter retrospective | 60 | - | Spray catheter | 50 | 64 | 5 | - | - | 4 | 15 | |
17 | Sengupta | 2015 | USA | Retrospective | 2006–2013 | 16 | - | Spray catheter | - | - | - | 6 | 9 | 3 | 3 |
18 | Ramay | 2017 | USA | Prospective | 2006–2012 | 50 | - | Spray catheter | 47 | 61.9 | 3.5 | - | 3 | 14 | |
19 | Trindade | 2017 | USA | Multicenter prospective | 2008–2014 | 18 | - | Spray catheter | 15 | 64.5 | 4 | 7 | 11 | 3 | 3 |
20 | Trindade | 2018 | USA | Multicenter retrospective | 2007–2015 | 27 | - | Spray catheter | 24 | 68 | 5 | 0 | 27 | 3 | 27 |
21 | Spiceland | 2019 | USA | Retrospective | 2007–2018 | 46 | - | Both spray catheter and cryoballoon | 42 | 66 | >3 | 15 | 31 | 2 | 23 |
22 | Kaul | 2020 | USA | Prospective | 2008–2019 | 57 | - | Spray catheter | 51 | - | 6.2 | 8 | 49 | 3 | 39 |
23 | Alshelleh | 2021 | USA | Retrospective | 2015–2019 | 71 | - | Both spray catheter and cryoballoon | 59 | 65.6 | 3.2 | 34 | 37 | - | 36 |
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Share and Cite
Papaefthymiou, A.; Norton, B.; Telese, A.; Ramai, D.; Murino, A.; Gkolfakis, P.; Vargo, J.; Haidry, R.J. Efficacy and Safety of Cryoablation in Barrett’s Esophagus and Comparison with Radiofrequency Ablation: A Meta-Analysis. Cancers 2024, 16, 2937. https://doi.org/10.3390/cancers16172937
Papaefthymiou A, Norton B, Telese A, Ramai D, Murino A, Gkolfakis P, Vargo J, Haidry RJ. Efficacy and Safety of Cryoablation in Barrett’s Esophagus and Comparison with Radiofrequency Ablation: A Meta-Analysis. Cancers. 2024; 16(17):2937. https://doi.org/10.3390/cancers16172937
Chicago/Turabian StylePapaefthymiou, Apostolis, Benjamin Norton, Andrea Telese, Daryl Ramai, Alberto Murino, Paraskevas Gkolfakis, John Vargo, and Rehan J. Haidry. 2024. "Efficacy and Safety of Cryoablation in Barrett’s Esophagus and Comparison with Radiofrequency Ablation: A Meta-Analysis" Cancers 16, no. 17: 2937. https://doi.org/10.3390/cancers16172937