Recent Advances in Palladium-Catalyzed Enantioselective Cyclization for the Construction of Atropisomers

Wang, Xilong; Ren, Wei; Zhang, Jingyi; Zhao, Shunwei; Zhou, Duo; Chen, Hui; Liu, Tingting

doi:10.3390/catal15040320

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Recent Advances in Palladium-Catalyzed Enantioselective Cyclization for the Construction of Atropisomers

by

Xilong Wang

¹,

Wei Ren

²,

Jingyi Zhang

¹,

Shunwei Zhao

¹,

Duo Zhou

¹,

Hui Chen

^1,* and

Tingting Liu

^1,3,*

¹

Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China

²

Henan Provincial Research Platform Service Center, Zhengzhou 450000, China

³

College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

^*

Authors to whom correspondence should be addressed.

Catalysts 2025, 15(4), 320; https://doi.org/10.3390/catal15040320

Submission received: 12 February 2025 / Revised: 17 March 2025 / Accepted: 24 March 2025 / Published: 27 March 2025

(This article belongs to the Special Issue Recent Advances in Palladium-Catalyzed Organic Synthesis)

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Abstract

Axially chiral structures have become increasingly common in modern materials and pharmaceuticals, especially as chiral ligands and organocatalysts, highlighting their growing significance. In the field of pharmaceutical research, there are several notable examples worth highlighting, such as the antibiotics vancomycin, Knipholone, and Mastigophorene A. Over the past decade, the availability of axially chiral compounds has significantly improved through advancements in existing strategies and the introduction of modern catalytic atroposelective synthesis concepts. These synthetic advancements not only broaden the scope of chemical reactions, but also facilitate the construction of axially chiral frameworks with high application value. Currently, various synthetic methods are available for achieving stereoselective synthesis of axially chiral compounds under catalyst control, including desymmetrization, (dynamic) kinetic resolution, cross-coupling reactions, and de novo ring-forming synthesis. This paper focuses on recent advances in constructing atropisomers through palladium-catalyzed asymmetric cyclization strategies.

Keywords: palladium-catalyzed; enantioselective cyclization; atropisomers

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MDPI and ACS Style

Wang, X.; Ren, W.; Zhang, J.; Zhao, S.; Zhou, D.; Chen, H.; Liu, T. Recent Advances in Palladium-Catalyzed Enantioselective Cyclization for the Construction of Atropisomers. Catalysts 2025, 15, 320. https://doi.org/10.3390/catal15040320

AMA Style

Wang X, Ren W, Zhang J, Zhao S, Zhou D, Chen H, Liu T. Recent Advances in Palladium-Catalyzed Enantioselective Cyclization for the Construction of Atropisomers. Catalysts. 2025; 15(4):320. https://doi.org/10.3390/catal15040320

Chicago/Turabian Style

Wang, Xilong, Wei Ren, Jingyi Zhang, Shunwei Zhao, Duo Zhou, Hui Chen, and Tingting Liu. 2025. "Recent Advances in Palladium-Catalyzed Enantioselective Cyclization for the Construction of Atropisomers" Catalysts 15, no. 4: 320. https://doi.org/10.3390/catal15040320

APA Style

Wang, X., Ren, W., Zhang, J., Zhao, S., Zhou, D., Chen, H., & Liu, T. (2025). Recent Advances in Palladium-Catalyzed Enantioselective Cyclization for the Construction of Atropisomers. Catalysts, 15(4), 320. https://doi.org/10.3390/catal15040320

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Recent Advances in Palladium-Catalyzed Enantioselective Cyclization for the Construction of Atropisomers

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