Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications

Othman, Mahmoud H.; Ito, Yoshihiro; Akimoto, Jun

doi:10.3390/polym15010184

Open AccessArticle

Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications

by

Mahmoud H. Othman

^1,2

,

Yoshihiro Ito

^1,2,3,*

and

Jun Akimoto

^1,*

¹

Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako 351-0198, Saitama, Japan

²

Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji 192-0397, Tokyo, Japan

³

Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako 351-0198, Saitama, Japan

^*

Authors to whom correspondence should be addressed.

Polymers 2023, 15(1), 184; https://doi.org/10.3390/polym15010184

Submission received: 23 November 2022 / Revised: 26 December 2022 / Accepted: 27 December 2022 / Published: 30 December 2022

(This article belongs to the Special Issue Polymer Surface and Interfacial Control for Biomedical Applications)

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Abstract

Notably, antibiofouling is an important and predominant technique adopted to improve the surfaces of biomaterials. In this study, polyethylene glycol-grafted polyethylene glycols bearing azidophenyl groups were synthesized and immobilized on polystyrene surfaces via photoirradiation. The prepared polymers were found to be highly soluble in water, and photoimmobilization with fluorescent proteins was confirmed based on micropatterning using a photomask. These polymers suppressed nonspecific interactions between proteins and cells on the substrate. Considering that photoimmobilization can be adopted for the covalent bond modification of various surfaces, the developed water-soluble and highly antibiofouling polymers appear to be useful in biomaterial preparation.

Keywords: photoreactive; azidophenyl; polyethylene glycol; photoimmobilization; cell adhesion; protein adsorption; antibiofouling

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MDPI and ACS Style

Othman, M.H.; Ito, Y.; Akimoto, J. Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications. Polymers 2023, 15, 184. https://doi.org/10.3390/polym15010184

AMA Style

Othman MH, Ito Y, Akimoto J. Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications. Polymers. 2023; 15(1):184. https://doi.org/10.3390/polym15010184

Chicago/Turabian Style

Othman, Mahmoud H., Yoshihiro Ito, and Jun Akimoto. 2023. "Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications" Polymers 15, no. 1: 184. https://doi.org/10.3390/polym15010184

APA Style

Othman, M. H., Ito, Y., & Akimoto, J. (2023). Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications. Polymers, 15(1), 184. https://doi.org/10.3390/polym15010184

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications

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