A Review of the Release Profiles and Efficacies of Chemotherapy Drug-Loaded Electrospun Membranes
Abstract
:1. Introduction
2. Release Profiles of the Chemotherapy Drug-Loaded Electrospun Membranes
2.1. Key Factors Affecting the Release Profiles
2.1.1. Polymers
2.1.2. Techniques of Electrospinning
2.2. Investigating the Release Profiles of Drug-Loaded Electrospun Membranes
2.2.1. Challenges in the Drug Release of Chemotherapy Drug-Loaded Electrospun Membranes
2.2.2. Strategies to Enhance the Release Profiles of Hydrophilic Chemotherapy Drug-Loaded Electrospun Membranes
2.2.3. Strategies to Enhance the Release Profiles of Hydrophobic Chemotherapy Drug-Loaded Electrospun Membranes
3. Therapeutic Effects
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Polymer | Degradation Duration in Crystalline Forms | Degradation Duration in Electrospun Forms | Hydrophobicity | Intended Use |
---|---|---|---|---|
PLA | More than one year [35,36,37]. | Approximately three months, less than half a year [38,39]. | Hydrophobic. | Long-term structural materials [9,28] and delivery systems [61,62,63,64]. |
PGA | A few months [41,42]. | Approximately or less than one month [43,44]. | Hydrophilic. | Tissue engineering material [35,43]. and tuning down the degradation period of long-term delivery systems [65,66]. |
PLGA | More than one year [49,50,51]. | Approximately two months [52]. | Hydrophilicity proportional to the GA ratio. | Mid-term flexible structural materials [29,31] and delivery system [67,68]. |
PCL | Up to two years [55]. | A 30% decline in fiber diameter after around three months [69]. | Hydrophobic. | Long-term structural materials [25,69] and delivery system [70,71]. |
Chitosan | Approximately one month [58]. | Limited amount of whole process degradation data. | Hydrophilic. | Short-term drug delivery system and tuning down the degradation period of other long-term delivery systems [59,60], specialty in antibacterial ability [57], and pH-responsive delivery [72]. |
Chemo Drug | Polymer Information | Techniques | Release Profile and Maximum Released % |
---|---|---|---|
DOX | PCL 80 kD | Blending | ~9 days logistic to ~30% [70] |
Shell PCL 80 kD + Core PEO 300 kD | Coaxial | ~10 days logistic to ~60% [82] | |
PLA 380 kD + Gelatin (Type A from porcine skin, 210–250 g Bloom) | Immersion Coating | ~6 days logistic to ~30% [80] | |
PLA 186 kD + PEG 4 kD | Blending (High Shear) with an enhancer | 30 days exponential to ~85% [61] | |
PLGA 50:50 81 kD + branched PEI 25 kD + PVA 85–124 kD | Surface Mod Coating | 50 days logistic to ~50% [83] | |
Core Chitosan (75–85% deacetylated 200 kD) + Shell PLA 150 kD | Coaxial Tri-Layer + Complex Encapsulation | ~30 days logistic to ~80% [59] | |
5-FU | PLA pellets 200 kD | Complex Encapsulation | ~4 days logistic to ~90% [62] |
PLGA 50:50 10 kD + gelatin (type A from porcine skin, 300 bloom) | Blending | ~10 days logistic to ~90% [84] | |
Shell PCL 80 kD + Core PVA 89–98 kD | Coaxial | ~25 days logistic to ~80% [78] | |
Core PVP + Shell PCL 70% + PVP 30% PCL 80 kD, PVP 360 kD | Coaxial | ~7 days logistic to ~80% [85] | |
Core Chitosan (75–85% deacetylated 200 kD) + Shell PLA 150 kD | Coaxial Tri-Layer | ~30 days linear to ~80% [59] | |
PTX | PCL 200 kD + PLGA 75:25 80 kD | Bi-layer | ~9 days logistic to ~35% [86] |
Core Chitosan (75–85% deacetylated 200 kD) + Shell PLA 150 kD | Coaxial Tri-Layer + Complex Encapsulation | ~21 days logistic to ~80% [59] | |
Dextran 450–650 kD + PLA 260 kD | Blending | ~35 days linear to ~90% [87] | |
PLA + Chitosan | Blending | 14 days logistic to ~30% [88] | |
PLA | Blending | ~40 days logistic to ~80% [63] | |
PLGA 50:50 33 kD | Blending | ~42 days logistic to ~80% [67] | |
CIS | PCL 45 kD + Chitosan 310 kD | Blending | 30 days linear to ~65% [60] |
PCL 70–90 kD | Blending + Release Enhancer | ~70 days linear to ~60% [71] | |
PLA 85–160 kD + PLGA 50:50 50–70 kD | Blending | ~33 days logistic to ~70% [89] | |
PLGA 50:50 33 kD | Blending | ~30 days exponential to ~100% [68] | |
PLA 100 kD | Blending | ~11 days logistic to ~45% [64] |
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Lin, Z.; Chen, H.; Xu, J.; Wang, J.; Wang, H.; Huang, S.; Xu, S. A Review of the Release Profiles and Efficacies of Chemotherapy Drug-Loaded Electrospun Membranes. Polymers 2023, 15, 251. https://doi.org/10.3390/polym15020251
Lin Z, Chen H, Xu J, Wang J, Wang H, Huang S, Xu S. A Review of the Release Profiles and Efficacies of Chemotherapy Drug-Loaded Electrospun Membranes. Polymers. 2023; 15(2):251. https://doi.org/10.3390/polym15020251
Chicago/Turabian StyleLin, Zhenyu, Hao Chen, Jiawei Xu, Jie Wang, Huijing Wang, Shifen Huang, and Shanshan Xu. 2023. "A Review of the Release Profiles and Efficacies of Chemotherapy Drug-Loaded Electrospun Membranes" Polymers 15, no. 2: 251. https://doi.org/10.3390/polym15020251