Abstract
Indomethacin (IND) as a non-selective cyclooxygenase 1 and 2 inhibitor administered orally causes numerous adverse effects, mostly related to the gastrointestinal tract. Moreover, when applied exogenously in topical preparations, there are obstacles to its permeation through the stratum corneum due to its low water solubility and susceptibility to photodegradation. In this work, solid dispersions (SDs) of IND with low-substituted hydroxypropyl cellulose (LHPC) were developed. The IND–SDs were incorporated into a hydroxypropyl guar (HPG) hydrogel to enhance drug solubility on the skin. The hydrogels were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (XRPD), Fourier-transform infrared spectroscopy (FTIR), viscosity, drug release, and unspecific cytotoxicity in mammalian cells. SEM showed a highly porous structure for SD hydrogels. DSC and XRPD studies showed that amorphous IND species were formed; therefore, these hydrogels exhibited superior drug release in comparison with IND raw material hydrogels. FTIR evidenced the presence of the hydrogen bond in the SD hydrogel. The rheology parameter viscosity increased across gels formulated with SDs in comparison with hydrogels with pure IND. In addition, IND–SD hydrogels combine the advantages of a suitable viscosity for dermal use and no potentially hazardous skin irritation. This study suggests that the formulated IND–SD hydrogels represent a suitable candidate for topical administration.
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MDPI and ACS Style
Dahma, Z.; Ibáñez-Escribano, A.; Fonseca-Berzal, C.; García-Rodríguez, J.J.; Álvarez-Álvarez, C.; Torrado-Salmerón, C.; Torrado-Santiago, S.; de la Torre-Iglesias, P.M.
Development, Characterization, and Cellular Toxicity Evaluation of Solid Dispersion-Loaded Hydrogel Based on Indomethacin. Polymers 2024, 16, 2174.
https://doi.org/10.3390/polym16152174
AMA Style
Dahma Z, Ibáñez-Escribano A, Fonseca-Berzal C, García-Rodríguez JJ, Álvarez-Álvarez C, Torrado-Salmerón C, Torrado-Santiago S, de la Torre-Iglesias PM.
Development, Characterization, and Cellular Toxicity Evaluation of Solid Dispersion-Loaded Hydrogel Based on Indomethacin. Polymers. 2024; 16(15):2174.
https://doi.org/10.3390/polym16152174
Chicago/Turabian Style
Dahma, Zaid, Alexandra Ibáñez-Escribano, Cristina Fonseca-Berzal, Juan José García-Rodríguez, Covadonga Álvarez-Álvarez, Carlos Torrado-Salmerón, Santiago Torrado-Santiago, and Paloma Marina de la Torre-Iglesias.
2024. "Development, Characterization, and Cellular Toxicity Evaluation of Solid Dispersion-Loaded Hydrogel Based on Indomethacin" Polymers 16, no. 15: 2174.
https://doi.org/10.3390/polym16152174
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