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Correction to Cells 2020, 9(8), 1807.
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Correction

Correction: Iannuzzi et al. Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer’s Disease Patients. Cells 2020, 9, 1807

by
Filomena Iannuzzi
1,
Rossana Sirabella
2,
Nadia Canu
3,4,
Thorsten J. Maier
5,
Lucio Annunziato
6,* and
Carmela Matrone
2,*
1
Department of Biomedicine, Aarhus University, Aarhus C, 8000 Aarhus, Denmark
2
Division of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, 80131 Naples, Italy
3
Department of System Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
4
Institute of Biochemistry and Cell Biology, CNR, 00015 Monterotondo, Rome, Italy
5
Paul-Ehrlich-Institut, (Federal Institute for Vaccines and Biomedicines), 63225 Langen, Germany
6
SDN Research Institute Diagnostics and Nuclear (IRCCS SDN), Gianturco, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Cells 2024, 13(12), 1026; https://doi.org/10.3390/cells13121026
Submission received: 27 May 2024 / Accepted: 3 June 2024 / Published: 13 June 2024
(This article belongs to the Special Issue Key Signalling Molecules in Aging and Neurodegeneration)
Browse Figure
Versions Notes
Error in Figure
In the original publication [1], there was a mistake in Figure 5 as published. Specifically, Western blots labeled with β-actin in the middle and right panels of 5 B and APP in the middle panel of 5 B were placed incorrectly during assembly. In addition, the Western blot labeled with pTyr (Figure 5A, left) was mistakenly flipped horizontally. The corrected panels and the corresponding optical density analyses are shown below. The authors apologize for the inconvenience and state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

  1. Iannuzzi, F.; Sirabella, R.; Canu, N.; Maier, T.J.; Annunziato, L.; Matrone, C. Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer’s Disease Patients. Cells 2020, 9, 1807. [Google Scholar] [CrossRef] [PubMed]
Cells 13 01026 g005
Figure 5. The amyloid precursor protein was phosphorylated at the Tyr residue in neurons from AD patients. (A) After 5 weeks in differentiating media, neurons from healthy controls (HCs) and AD patients and one FTD patient were processed for pTyr IP using mouse anti-pTyr magnetic beads- conjugated antibody (4G10) and analyzed by WB using rabbit anti-APP antibody (Y188). Membranes were blotted with anti-mouse IgG, and the pTyr band (input) migrating at 25 kDa was used as a loading control. (B) WB analysis of basal APP levels using the rabbit anti-APP antibody (Y188). β-actin was used as a loading control. (C,D) Densitometric analysis of pAPP-Tyr levels in AD patients vs. HCs (C) and total APP levels expressed as a percentage of HCs (D). Mean optical density values were calculated as the ratio of pAPP-Tyr levels relative to basal APP levels (after normalization to β-actin) from each sample (experiments from each sample were repeated three times, n = 3). Statistically significant differences were calculated using Student’s t-test. ** p < 0.01 vs. HCs.
Figure 5. The amyloid precursor protein was phosphorylated at the Tyr residue in neurons from AD patients. (A) After 5 weeks in differentiating media, neurons from healthy controls (HCs) and AD patients and one FTD patient were processed for pTyr IP using mouse anti-pTyr magnetic beads- conjugated antibody (4G10) and analyzed by WB using rabbit anti-APP antibody (Y188). Membranes were blotted with anti-mouse IgG, and the pTyr band (input) migrating at 25 kDa was used as a loading control. (B) WB analysis of basal APP levels using the rabbit anti-APP antibody (Y188). β-actin was used as a loading control. (C,D) Densitometric analysis of pAPP-Tyr levels in AD patients vs. HCs (C) and total APP levels expressed as a percentage of HCs (D). Mean optical density values were calculated as the ratio of pAPP-Tyr levels relative to basal APP levels (after normalization to β-actin) from each sample (experiments from each sample were repeated three times, n = 3). Statistically significant differences were calculated using Student’s t-test. ** p < 0.01 vs. HCs.
Cells 13 01026 g005
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MDPI and ACS Style

Iannuzzi, F.; Sirabella, R.; Canu, N.; Maier, T.J.; Annunziato, L.; Matrone, C. Correction: Iannuzzi et al. Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer’s Disease Patients. Cells 2020, 9, 1807. Cells 2024, 13, 1026. https://doi.org/10.3390/cells13121026

AMA Style

Iannuzzi F, Sirabella R, Canu N, Maier TJ, Annunziato L, Matrone C. Correction: Iannuzzi et al. Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer’s Disease Patients. Cells 2020, 9, 1807. Cells. 2024; 13(12):1026. https://doi.org/10.3390/cells13121026

Chicago/Turabian Style

Iannuzzi, Filomena, Rossana Sirabella, Nadia Canu, Thorsten J. Maier, Lucio Annunziato, and Carmela Matrone. 2024. "Correction: Iannuzzi et al. Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer’s Disease Patients. Cells 2020, 9, 1807" Cells 13, no. 12: 1026. https://doi.org/10.3390/cells13121026

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