Key Signalling Molecules in Aging and Neurodegeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (15 June 2021) | Viewed by 145793
Special Issue Editors
Interests: Ca2+ homeostasis; mitochondria; endoplasmic reticulum; oraganelle contact sites; MAM; bioenergetics; Alzheimer's disease; presenilin; neurodegeneration
Interests: Ca2+ homeostasis; Alzheimer's disease; presenilin; neurodegeneration; mitochondria; endoplasmic reticulum; organelle contact sites; MAM; bioenergetics; metabolism
Special Issue Information
Dear Colleagues,
The human lifespan has drastically increased in the past decades and the percentage of the aged population is constantly rising, posing major health and economic challenges. Aging invariably increases the risk of several diseases, such as those linked to neurodegeneration, cancer, stroke and diabetes. In this Special Issue, the focus will be on neurodegenerative disorders of the elderly, particularly Parkinson and Alzheimer diseases. Both conditions are characterized by the progressive degeneration of specific neuronal circuits, through largely unknown pathogenic mechanisms, and are devoid of valid therapeutic approaches. Therefore, the need to find novel targets and early biomarkers to develop appropriate pharmacological strategies appears urgent. In this scenario, precise knowledge of the specific cellular and molecular processes behind aging and neurodegeneration is a priority for the scientific community.
The aim of this Special Issue is to provide an overview of the main signalling pathways and molecules involved in the process of aging, highlighting their intimate connection with the onset of neurodegenerative disorders.
Prof. Paola Pizzo
Dr. Riccardo Filadi
Guest Editors
Manuscript Submission Information
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Keywords
- aging
- neurodegeneration
- calcium
- oxidative stress
- cAMP
- mitochondria
- proteostasis
- autophagy
- immunity
- inflammation
- senescence
- ER stress
- UPR
- Alzheimer
- metabolism