Polycystic Ovary Syndrome and Gut Microbiota: Phenotype Matters

Suturina, Larisa; Belkova, Natalia; Igumnov, Ilia; Lazareva, Ludmila; Danusevich, Irina; Nadeliaeva, Iana; Sholokhov, Leonid; Rashidova, Maria; Belenkaya, Lilia; Belskikh, Aleksey; Sharifulin, Eldar; Ievleva, Kseniia; Babaeva, Natalia; Egorova, Irina; Salimova, Madinabonu; Kuzmin, Mikhail; Tiumentseva, Daria; Klimenko, Elizaveta; Sidorova, Tuyana; Atalyan, Alina

doi:10.3390/life13010007

Open AccessArticle

Polycystic Ovary Syndrome and Gut Microbiota: Phenotype Matters

by

Larisa Suturina

^*,†

,

Natalia Belkova

^†

,

Ilia Igumnov

,

Ludmila Lazareva

,

Irina Danusevich

,

Iana Nadeliaeva

,

Leonid Sholokhov

,

Maria Rashidova

,

Lilia Belenkaya

,

Aleksey Belskikh

,

Eldar Sharifulin

,

Kseniia Ievleva

,

Natalia Babaeva

,

Irina Egorova

,

Madinabonu Salimova

,

Mikhail Kuzmin

,

Daria Tiumentseva

,

Elizaveta Klimenko

,

Tuyana Sidorova

and

Alina Atalyan

Federal State Public Institution «Scientific Center for Family Health and Human Reproduction Problems», 16, Timiryazeva Str., 664003 Irkutsk, Russia

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Life 2023, 13(1), 7; https://doi.org/10.3390/life13010007

Submission received: 31 October 2022 / Revised: 5 December 2022 / Accepted: 16 December 2022 / Published: 20 December 2022

(This article belongs to the Special Issue Polycystic Ovary Syndrome: Current Knowledge and Future Perspectives)

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Abstract

Abnormalities in gut microbiota diversity are considered important mechanisms in metabolic disorders in polycystic ovarian syndrome (PCOS). However, the data on the association of these disorders with the PCOS phenotype remain controversial. The objectives of this study were to estimate the alpha diversity of the gut microbiota of healthy women and PCOS patients depending on phenotype. The study participants (184 premenopausal women: 63 with PCOS, 121 without PCOS) were recruited during the annual employment assessment in the Irkutsk Region and the Buryat Republic (Russia) in 2016–2019. For PCOS diagnosis, we used the Rotterdam (2003) criteria and definitions of PCOS phenotypes. Five indexes of alpha diversity (ASV, Shannon, Simpson, Chao, and ACE) were estimated for the gut microbiota in all participants using amplicon metasequencing. As a result, two out of five alpha diversity indexes showed a statistical difference between the non-PCOS and PCOS groups. We did not find a significant difference in the alpha diversity of gut microbiota in the subgroups of women with hyperandrogenic PCOS phenotypes vs non-androgenic phenotype D and the group of women with the presence of only one of the PCOS criteria. Nevertheless, “classic” PCOS phenotypes demonstrated the most significant decrease in alpha diversity compared with healthy women without any signs of PCOS.

Keywords: PCOS; phenotype; hyperandrogenism; gut microbiota; alpha diversity indexes; amplicon metasequencing

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MDPI and ACS Style

Suturina, L.; Belkova, N.; Igumnov, I.; Lazareva, L.; Danusevich, I.; Nadeliaeva, I.; Sholokhov, L.; Rashidova, M.; Belenkaya, L.; Belskikh, A.; et al. Polycystic Ovary Syndrome and Gut Microbiota: Phenotype Matters. Life 2023, 13, 7. https://doi.org/10.3390/life13010007

AMA Style

Suturina L, Belkova N, Igumnov I, Lazareva L, Danusevich I, Nadeliaeva I, Sholokhov L, Rashidova M, Belenkaya L, Belskikh A, et al. Polycystic Ovary Syndrome and Gut Microbiota: Phenotype Matters. Life. 2023; 13(1):7. https://doi.org/10.3390/life13010007

Chicago/Turabian Style

Suturina, Larisa, Natalia Belkova, Ilia Igumnov, Ludmila Lazareva, Irina Danusevich, Iana Nadeliaeva, Leonid Sholokhov, Maria Rashidova, Lilia Belenkaya, Aleksey Belskikh, and et al. 2023. "Polycystic Ovary Syndrome and Gut Microbiota: Phenotype Matters" Life 13, no. 1: 7. https://doi.org/10.3390/life13010007

APA Style

Suturina, L., Belkova, N., Igumnov, I., Lazareva, L., Danusevich, I., Nadeliaeva, I., Sholokhov, L., Rashidova, M., Belenkaya, L., Belskikh, A., Sharifulin, E., Ievleva, K., Babaeva, N., Egorova, I., Salimova, M., Kuzmin, M., Tiumentseva, D., Klimenko, E., Sidorova, T., & Atalyan, A. (2023). Polycystic Ovary Syndrome and Gut Microbiota: Phenotype Matters. Life, 13(1), 7. https://doi.org/10.3390/life13010007

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Polycystic Ovary Syndrome and Gut Microbiota: Phenotype Matters

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