Exploratory Analysis of the Role of Radiomic Features in the Differentiation of Oncocytoma and Chromophobe RCC in the Nephrographic CT Phase
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Image Acquisition
2.3. Image Analysis
2.4. Statistical Analysis and Feature Selection
2.5. Model Elaboration
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Oncocytoma | Chromophobe | |
---|---|---|
Number of cases | 19 | 19 |
Median age (range) | 69 (86–57) | 70 (85–38) |
Sex | ||
Female | 11 (57.9%) | 8 (42.1%) |
Male | 8 (42.1%) | 11 (57.9%) |
Laterality | ||
Right | 8 (42.1%) | 11 (57.9%) |
Left | 11 (57.9%) | 8 (42.1%) |
Radiomic Group | Excellent | Good | Moderate | Poor |
---|---|---|---|---|
Shape | 10 (71.42) | 1 (7.14) | 3 (21.43) | 0 (0) |
First order | 16 (88.89) | 2 (11.11) | 0(0) | 0 (0) |
GLCM | 4 (18.18) | 15 (68.18) | 3 (13.64) | 0 (0) |
GLRLM | 3 (18.75) | 7 (43.75) | 3 (18.75) | 3 (18.75) |
GLSZM | 2 (12.50) | 7 (43.75) | 5 (31.25) | 2 (12.50) |
GLDM | 3 (21.43) | 4 (28.57) | 4 (28.57) | 3 (21.43) |
NGTDM | 3 (60.00) | 1 (20.00) | 1 (20.00) | 0(0) |
Radiomic Feature | Oncocytoma | Chromophobe | p-Value |
---|---|---|---|
Major axis length (shape) | 25.62 (10.41) | 32.09 (22.62) | 0.02 * |
10th percentile (first order) | 734.28 (99.87) | 732.86 (105.68) | 0.96 |
Interquartile range (first order) | 62.50 (20.48) | 52.19 (21.77) | 0.07 |
Kurtosis (first order) | 3.47 (1.52) | 3.65 (1.72) | 0.28 |
Minimum (first order) | 563.96 (108.25) | 557.75 (149.95) | 0.89 |
Strength (NGTDM) | 0.15 (0.35) | 0.06 (0.17) | 0.04 * |
Model | Accuracy | F1-Score | Precision | Recall | Specificity | NPV | AUC (95% CI) |
---|---|---|---|---|---|---|---|
Support vector machine | 0.50 (0.10) | 0.47 (0.12) | 0.50 (0.23) | 0.50 (0.10) | 0.25 (0.20) | 0.60 (0.38) | 0.56 (0.21–0.70) |
Random forest | 0.75 (0.16) | 0.75 (0.20) | 0.75 (0.22) | 0.75 (0.16) | 0.63 (0.25) | 0.54 (0.14) | 0.59 (0.24–0.92) |
Logistic regression | 0.75 (0.21) | 0.73 (0.21) | 0.83 (0.16) | 0.75 (0.19) | 0.63 (0.23) | 0.80 (0.20) | 0.75 (0.55–1.00) |
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Aymerich, M.; García-Baizán, A.; Franco, P.N.; Otero-García, M. Exploratory Analysis of the Role of Radiomic Features in the Differentiation of Oncocytoma and Chromophobe RCC in the Nephrographic CT Phase. Life 2023, 13, 1950. https://doi.org/10.3390/life13101950
Aymerich M, García-Baizán A, Franco PN, Otero-García M. Exploratory Analysis of the Role of Radiomic Features in the Differentiation of Oncocytoma and Chromophobe RCC in the Nephrographic CT Phase. Life. 2023; 13(10):1950. https://doi.org/10.3390/life13101950
Chicago/Turabian StyleAymerich, María, Alejandra García-Baizán, Paolo Niccolò Franco, and Milagros Otero-García. 2023. "Exploratory Analysis of the Role of Radiomic Features in the Differentiation of Oncocytoma and Chromophobe RCC in the Nephrographic CT Phase" Life 13, no. 10: 1950. https://doi.org/10.3390/life13101950