Next Article in Journal
Differential Gut Microbiome Profiles in Long-Distance Endurance Cyclists and Runners
Next Article in Special Issue
Green Catalysis: The Role of Medicinal Plants as Food Waste Decomposition Enhancers/Accelerators
Previous Article in Journal
Evaluating the Role of Aspirin in Liver Disease: Efficacy, Safety, Potential Benefits and Risks
Previous Article in Special Issue
Localization of Secondary Metabolites in Relict Gymnosperms of the Genus Sequoia In Vivo and in Cell Cultures In Vitro, and the Biological Activity of Their Extracts
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Life
Volume 14
Issue 12
10.3390/life14121702
life-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity

by
Gustavo A. Hernandez-Fuentes
1,2,3,*,
Osiris G. Delgado-Enciso
1,
Edgar G. Larios-Cedeño
2,
Juan M. Sánchez-Galindo
2,
Silvia G. Ceballos-Magaña
4,
Kayim Pineda-Urbina
3,
Mario A. Alcalá-Pérez
5,
Nancy E. Magaña-Vergara
3,
Josuel Delgado-Enciso
6,
Uriel Díaz-Llerenas
5,
Janet Diaz-Martinez
7,
Idalia Garza-Veloz
5,
Margarita L. Martinez-Fierro
5,
Iram P. Rodriguez-Sanchez
8 and
Ivan Delgado-Enciso
1,2,9,*
1
Department of Molecular Medicine, School of Medicine, University of Colima, Colima 28040, Mexico
2
State Cancerology Institute of Colima, Health Services of the Mexican Social Security Institute for Welfare (IMSS-BIENESTAR), Colima 28085, Mexico
3
Faculty of Chemical Sciences, University of Colima, Coquimatlan 28400, Mexico
4
Faculty of Sciences, University of Colima, Colima 28045, Mexico
5
Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico
6
Foundation for Ethics, Education, and Cancer Research of the State Cancer Institute of Colima AC, Colima 28085, Mexico
7
Research Center in Minority Institutions, Robert Stempel College of Public Health, Florida International University (FIU-RCMI), Miami, FL 33199, USA
8
Molecular and Structural Physiology Laboratory, School of Biological Sciences, Autonomous University of Nuevo Leon, San Nicolas de los Garza 66455, Mexico
9
Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA
*
Authors to whom correspondence should be addressed.
Life 2024, 14(12), 1702; https://doi.org/10.3390/life14121702
Submission received: 23 November 2024 / Revised: 18 December 2024 / Accepted: 21 December 2024 / Published: 23 December 2024
(This article belongs to the Special Issue Plants as a Promising Biofactory for Bioactive Compounds: 2nd Edition)
Browse Figures
Versions Notes

Abstract

Background: Annona muricata L. (guanabana) leaves are rich in bioactive compounds with potential antioxidant properties. In the state of Colima, both ethanolic extracts and infusions are traditionally used in folk medicine to address various ailments. This study aimed to evaluate and compare the phytochemical composition and antioxidant activities of ethanolic extracts and infusions of A. muricata leaves from three geographic regions in Colima, Mexico, with a focus on how geographic origin affects their bioactive properties. Methods: Ethanolic extracts and infusions were prepared from A. muricata leaves and analyzed using phytochemical screening; DPPH, total antioxidant capacity (TAC), and total phenolic content (TPC) measurements; and HPLC. TLC was also conducted to examine the presence of specific compounds, such as flavonoids and phenols. Results: Both the ethanolic extracts and infusions contained significant levels of alkaloids, flavonoids, tannins, and phenolic compounds. The infusions demonstrated superior antioxidant capacity, with DPPH inhibition values of 72.5%, 68.3%, and 65.1% in the northern, central, and southern regions, respectively, compared to the ethanolic extracts’ values of 50.3%, 48.9%, and 45.0%. HPLC identified quercetin as a major compound across all samples. Geographically, the northern region exhibited higher concentrations of bioactive compounds, particularly total flavonoid content (TFC) and iron-reducing power (FRPA). Conclusions: Both the ethanolic extracts and infusions of A. muricata leaves exhibited significant antioxidant properties, with the infusions showing superior performance. The results suggest that A. muricata infusions may have potential applications in managing oxidative stress-related diseases such as cancer and diabetes. Exploring their use in traditional medicine and employing this type of approach can help discern the metabolite profile responsible for these bioactivities. Geographic factors influence the bioactive profile of the plant, and further research is needed to isolate specific bioactive compounds and elucidate their therapeutic mechanisms.
Keywords: Annona muricata; traditional medicine; phytochemistry; antioxidant activity; flavonoids; polyphenols Annona muricata; traditional medicine; phytochemistry; antioxidant activity; flavonoids; polyphenols

Share and Cite

MDPI and ACS Style

Hernandez-Fuentes, G.A.; Delgado-Enciso, O.G.; Larios-Cedeño, E.G.; Sánchez-Galindo, J.M.; Ceballos-Magaña, S.G.; Pineda-Urbina, K.; Alcalá-Pérez, M.A.; Magaña-Vergara, N.E.; Delgado-Enciso, J.; Díaz-Llerenas, U.; et al. Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity. Life 2024, 14, 1702. https://doi.org/10.3390/life14121702

AMA Style

Hernandez-Fuentes GA, Delgado-Enciso OG, Larios-Cedeño EG, Sánchez-Galindo JM, Ceballos-Magaña SG, Pineda-Urbina K, Alcalá-Pérez MA, Magaña-Vergara NE, Delgado-Enciso J, Díaz-Llerenas U, et al. Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity. Life. 2024; 14(12):1702. https://doi.org/10.3390/life14121702

Chicago/Turabian Style

Hernandez-Fuentes, Gustavo A., Osiris G. Delgado-Enciso, Edgar G. Larios-Cedeño, Juan M. Sánchez-Galindo, Silvia G. Ceballos-Magaña, Kayim Pineda-Urbina, Mario A. Alcalá-Pérez, Nancy E. Magaña-Vergara, Josuel Delgado-Enciso, Uriel Díaz-Llerenas, and et al. 2024. "Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity" Life 14, no. 12: 1702. https://doi.org/10.3390/life14121702

APA Style

Hernandez-Fuentes, G. A., Delgado-Enciso, O. G., Larios-Cedeño, E. G., Sánchez-Galindo, J. M., Ceballos-Magaña, S. G., Pineda-Urbina, K., Alcalá-Pérez, M. A., Magaña-Vergara, N. E., Delgado-Enciso, J., Díaz-Llerenas, U., Diaz-Martinez, J., Garza-Veloz, I., Martinez-Fierro, M. L., Rodriguez-Sanchez, I. P., & Delgado-Enciso, I. (2024). Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity. Life, 14(12), 1702. https://doi.org/10.3390/life14121702

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop