The Role of Neutrophyl-to-Lymphocyte Ratio as a Predictor of Ovarian Torsion in Children: Results of a Multicentric Study
Abstract
:1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group OT (n = 75) | Group Non-OT (n = 35) | p-Value | OR (95%CI) | |
---|---|---|---|---|
Age (years); median (IQR) | 10.9 (7.3–13.2) | 12.1 (11.2–13.7) | <0.001 | - |
Weight (kg); mean (SD) | 35.9 (12.1) | 49.4 (16.1) | <0.001 | - |
Menstruation status; n (%)
| 54 (72) | 23 (65.7) | 0.449 | 1.34 (0.56–3.17) |
21 (28) | 12 (34.3) | |||
Clinical features; n (%)
| 59 (78.7) | 25 (71.4) | 0.405 | 1.47 (0.58–3.69) |
56 (74.7) | 15 (42.9) | 0.001 | 3.92 (1.68–9.18) | |
2 (2.7) | 1 (2.9) | 0.577 | 0.93 (0.08–10.63) | |
10 (13.3) | 5 (14.3) | 0.892 | 0.92 (0.29–2.94) | |
4 (5.3) | 6 (17.1) | 0.046 | 0.27 (0.07–1.03) | |
5 (6.7) | 5 (14.3) | 0.195 | 0.42 (0.12–1.59) | |
7 (9.3) | 5 (14.3) | 0.438 | 0.62 (0.18–2.10) | |
Time since symptoms onset (hours); median (IQR) | 12 (4–48) | 18 (7–72) | 0.029 | - |
Previous episodes; n (%) | 15 (20) | 6 (17.1) | 0.722 | 1.21 (0.42–3.44) |
OT Group (n = 75) | Non-OT Group (n = 35) | p-Value | |
---|---|---|---|
Affected side; n(%)
| 45 (60) 30 (40) | 29 (82.9) 6 (17.1) | 0.017 |
Adnexal mass; n(%)
| 38 (50.7) 8 (10.7) 29 (38.7) | 23 (65.7) 5 (14.3) 7 (20.0) | 0.064 |
Ovarian volumen (ml); median (IQR) | 63 (42–97) | 51 (34–78) | 0.013 |
Ovarian volumen ratio; median (IQR) | 2.8 (2.1–3.5) | 1.9 (1.5–2.4) | 0.021 |
Absence of Doppler flow; n(%) | 72 (96) | 32 (91.4) | 0.325 |
Pelvic free fluid; n(%) | 40 (53.3) | 22 (62.9) | 0.348 |
OT Group (n = 75) | Non-OT Group (n = 35) | p-Value | |
---|---|---|---|
Leukocytes (×109/L) | 10.8 (8.6–13.4) | 7.84 (5.73–10.2) | <0.001 |
Neutrophils (×109/L) | 8.58 (6.34–13.22) | 3.48 (2.81–6.04) | <0.001 |
Lymphocytes (×109/L) | 1.64 (1.34–1.99) | 2.59 (1.84–3.62) | <0.001 |
Monocytes (×109/L) | 0.43 (0.34–0.76) | 0.44 (0.32–0.61) | 0.942 |
Platelets (×109/L) | 289 (243–329) | 295 (240–355) | 0.785 |
NLR | 4.6 (3.1–7.9) | 1.58 (1.02–2.07) | <0.001 |
PLR | 174.4 (126.8–278.4) | 185.7 (99.1–295) | <0.001 |
SIRI (×109/L) | 2.2 (1.1–3.9) | 0.6 (0.4–1.2) | <0.001 |
SII (×109/L) | 1385 (796–2542) | 391 (265–673) | <0.001 |
CRP (mg/L) | 2.9 (1.5–4.1) | 0.9 (0.5–3.5) | 0.145 |
Glucose (mg/dL) | 100 (84–114) | 98 (83–101) | 0.352 |
Fibrinogen (mg/dL) | 337 (255–427) | 286 (257–402) | 0.589 |
Ionogram
| 138 (136–140) 4 (3.7–4.4) 105 (103–106) | 138 (136–140) 3.9 (3.8–4.2) 106 (105–108) | 0.863 0.599 0.242 |
Tumour markers
| 1.2 (0.2–2) | 2 (1.2–2) | 0.089 |
1.7 (1.3–3.2) | 1.8 (1.3–10.5) | 0.415 | |
23.7 (15.9–44.7) | 14.8 (11.4–26.4) | 0.072 | |
17.7 (9.7–26.0) | 16.9 (12.1–35.5) | 0.949 | |
10.4 (9.4–19.8) | 10.4 (8.7–15.3) | 0.853 | |
1.0 (0.5–1.2) | 0.5 (0.5–4) | 0.600 |
AUC | Cut-Off Point | Sensibility | Specificity | p Value | |
---|---|---|---|---|---|
NLR | 0.918 | 2.57 | 92.4 | 90.1 | <0.001 |
SII (×109/L) | 0.895 | 717.8 | 88.9 | 81.8 | <0.001 |
WBC (×109/L) | 0.872 | 9,235 | 84.4 | 81.8 | <0.001 |
SIRI (×109/L) | 0.824 | 1.25 | 75.6 | 81.8 | <0.001 |
OV (mL) | 0.797 | 58 | 77.4 | 75.1 | 0.025 |
OVR | 0.794 | 2.3 | 77.8 | 72.7 | 0.012 |
PLR | 0.739 | 157 | 73.8 | 78.2 | 0.002 |
TSSO (min) | 0.588 | 296 | 68.1 | 79.3 | 0.245 |
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Delgado-Miguel, C.; Arredondo-Montero, J.; Moreno-Alfonso, J.C.; San Basilio, M.; Peña Pérez, R.; Carrera, N.; Aguado, P.; Fuentes, E.; Díez, R.; Hernández-Oliveros, F. The Role of Neutrophyl-to-Lymphocyte Ratio as a Predictor of Ovarian Torsion in Children: Results of a Multicentric Study. Life 2024, 14, 889. https://doi.org/10.3390/life14070889
Delgado-Miguel C, Arredondo-Montero J, Moreno-Alfonso JC, San Basilio M, Peña Pérez R, Carrera N, Aguado P, Fuentes E, Díez R, Hernández-Oliveros F. The Role of Neutrophyl-to-Lymphocyte Ratio as a Predictor of Ovarian Torsion in Children: Results of a Multicentric Study. Life. 2024; 14(7):889. https://doi.org/10.3390/life14070889
Chicago/Turabian StyleDelgado-Miguel, Carlos, Javier Arredondo-Montero, Julio César Moreno-Alfonso, María San Basilio, Raquel Peña Pérez, Noela Carrera, Pablo Aguado, Ennio Fuentes, Ricardo Díez, and Francisco Hernández-Oliveros. 2024. "The Role of Neutrophyl-to-Lymphocyte Ratio as a Predictor of Ovarian Torsion in Children: Results of a Multicentric Study" Life 14, no. 7: 889. https://doi.org/10.3390/life14070889