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Utility of Scanning Electron Microscopy Elemental Analysis Using the ‘NanoSuit’ Correlative Light and Electron Microscopy Method in the Diagnosis of Lanthanum Phosphate Deposition in the Esophagogastroduodenal Mucosa
 
 
Review
Peer-Review Record

Detection Rate of Culprit Tumors Causing Osteomalacia Using Somatostatin Receptor PET/CT: Systematic Review and Meta-Analysis

by Marie Meyer 1,†, Marie Nicod Lalonde 1,†, Nathalie Testart 1, Mario Jreige 1, Christel Kamani 1, Sarah Boughdad 1, Barbara Muoio 2, Fabio Becce 3,4, Niklaus Schaefer 1,4, Christian Candrian 5, Luca Giovanella 6,7, John O. Prior 1,4, Giorgio Treglia 1,4,6,8,*,‡ and Martin Riegger 9,‡
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Submission received: 28 November 2019 / Revised: 16 December 2019 / Accepted: 17 December 2019 / Published: 18 December 2019
(This article belongs to the Section Medical Imaging and Theranostics)

Round 1

Reviewer 1 Report

This review addresses an innovative issue for nuclear medicine and specifically for PET-CT with SSR .

The methodology is appropriate with clear inclusion criteria.

Author Response

We thank the Reviewer for having appreciated our efforts.

Reviewer 2 Report

Your paper is well written to report the first systemic review of diagnosing phosphaturic mesenchymal tumors (PMT) causing osteomalacia by using SSTR PET/CT and meta-analysis. The following is minor questions to improve your paper.

How can we differentiate PMT from granuloma or neuroendocrine tumor on SSTR PET/CT? Why did MRI miss PMT lesions? Please illustrate  true and false positive cases of SSTR PET/CT,  and  MRI

Author Response

According to the Reviewer's suggestions we have added some comments about false positive and false negative findings of SSTR-PET/CT and MRI in the discussion of the revised manuscript.

As this is a meta-analysis we have choosen to not present illustrative cases of TIO. The selected figures are focused on the statistical analysis. 

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