Assessing Baveno VI Criteria Using Liver Stiffness Measured with a 2D-Shear Wave Elastography Technique
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. 2D-SWE Evaluation
2.3. Upper Digestive Endoscopy
2.4. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameter | All Subjects (n = 208) | no HRV n = 134 (64.4%) | HRV n = 74 (35.6%) | p Value |
---|---|---|---|---|
Age (years) | 58.2 ± 10.4 | 58.7 ± 10.3 | 57.2 ± 10.7 | p = 0.322 |
Gender | ||||
Female | 58.2% (121/208) | 68% (91) | 40.5% (30) | p = 0.0002 |
Male | 41.8% (87/208) | 32% (43) | 59.5% (44) | p = 0.0002 |
Etiology | ||||
HCV | 73% (152/208) | 82% (110) | 56.8% (42) | p = 0.0002 |
HBV | 5.8% (12/208) | 4.5% (6) | 8.1% (6) | p = 0.450 |
ALD | 16.9% (35/208) | 10.5% (14) | 28.4% (21/74) | p = 0.0019 |
NAFLD | 2.4% (5/208) | 1.5% (2) | 4% (3/74) | p = 0.511 |
PBC | 1.9% (4/208) | 1.5% (2) | 2.7% (2/74) | p = 0.939 |
Platelet count (×109/L) | 134.40 ± 58.66 | 158.19 ± 52.15 | 91.33 ± 43.38 | p < 0.0001 |
LS by 2D-SWE (kPa) | 12.70 ± 2.56 | 11.89 ± 2.39 | 14.25 ± 2.12 | p < 0.0001 |
Without EV | No HRV (Gr 1 EV) | HRV | |
---|---|---|---|
All subjects | 82/208 (39.4%) | 52/208 (25%) | 74/208 (35.6%) |
LS < 12 kPa (n = 85) | 59/85 (69.4%) | 22/85 (25.9%) | 4/85 (4.7%) |
LS > 12 kPa (n = 123) | 23/123 (18.7%) | 30/123 (24.4%) | 70/123 (56.9%) |
Platelets > 150 000/mm3 (n = 84) | 64/84 (76.2%) | 15/84 (17.9%) | 5/84 (5.9%) |
Platelets < 150 000/mm3 (n = 124) | 18/124 (14.5%) | 37/124 (29.8%) | 69/124 (55.7%) |
Within 2D-SWE Baveno criteria (n = 52) | 47/52 (90.4%) | 4/52 (7.7%) | 1/52 (1.9%) |
Outside 2D-SWE Baveno criteria (n = 156) | 36/156 (23.1%) | 47/156 (30.1%) | 73/156 (46.8%) |
Parameter | LS by 2D-SWE | Platelet Count | 2D-SWE Baveno Criteria |
---|---|---|---|
Se (%) (95% CI) | 94.5 [86.7–98.5] | 93.2 [84.9–97.8] | 98.6 [92.7–100.0] |
Sp (%) (95% CI) | 60.5 [51.6–68.8] | 58.9 [50.1–67.4] | 38.0 [29.8–46.8] |
PPV (%) (95% CI) | 56.9 [47.7–65.8] | 55.6 [46.5–64.6] | 46.8 [38.8–54.9] |
NPV (%) (95% CI) | 95.3 [88.3–98.7] | 94.0 [86.7–98.0] | 98.1 [89.6–100.0] |
LR+ (95% CI) | 2.4 [1.9–3.0] | 2.2 [1.8–2.8] | 1. 6 [1.4–1.8] |
LR− (95% CI) | 0.08 [0.03–0.2] | 0.11 [0.05–0.3] | 0.036 [0.005–0.3] |
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Fofiu, R.; Bende, F.; Popescu, A.; Șirli, R.; Miuţescu, B.; Sporea, I. Assessing Baveno VI Criteria Using Liver Stiffness Measured with a 2D-Shear Wave Elastography Technique. Diagnostics 2021, 11, 737. https://doi.org/10.3390/diagnostics11050737
Fofiu R, Bende F, Popescu A, Șirli R, Miuţescu B, Sporea I. Assessing Baveno VI Criteria Using Liver Stiffness Measured with a 2D-Shear Wave Elastography Technique. Diagnostics. 2021; 11(5):737. https://doi.org/10.3390/diagnostics11050737
Chicago/Turabian StyleFofiu, Renata, Felix Bende, Alina Popescu, Roxana Șirli, Bogdan Miuţescu, and Ioan Sporea. 2021. "Assessing Baveno VI Criteria Using Liver Stiffness Measured with a 2D-Shear Wave Elastography Technique" Diagnostics 11, no. 5: 737. https://doi.org/10.3390/diagnostics11050737