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Article

A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies

by
Gianluca Sambataro
1,2,*,
Chiara Alfia Ferrara
1,
Carla Spadaro
1,
Sebastiano Emanuele Torrisi
1,
Giovanna Vignigni
1,
Ada Vancheri
1,
Giuseppe Muscato
1,
Nicoletta Del Papa
3,
Michele Colaci
4,
Lorenzo Malatino
4,
Stefano Palmucci
5,
Lorenzo Cavagna
6,
Giovanni Zanframundo
6,
Francesco Ferro
7,
Chiara Baldini
7,
Domenico Sambataro
2,† and
Carlo Vancheri
1,†
1
Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. “Policlinico-San Marco”, University of Catania, 95123 Catania, Italy
2
Outpatient Clinic of Rheumatology, Artroreuma S.R.L., Corso S. Vito 53, 95030 Mascalucia (CT), Italy
3
Day Hospital of Rheumatology, Department of Rheumatology, ASST G.Pini-CTO, Piazza Cardinal Ferrari 1, 20122 Milan, Italy
4
Internal Medicine Unit, Department of Clinical and Experimental Medicine, Cannizzaro Hospital, University of Catania, Via Messina 829, 95100 Catania, Italy
5
Department of Medical, Surgical Sciences and Advanced Technologies, “G.F. Ingrassia”, University of Catania, Via S. Sofia 68 Catania, 95123 Catania, Italy
6
Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Piazzale C. Golgi 19, 27100 Pavia, Italy
7
Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Via Roma 24, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work and share last authorship.
Diagnostics 2022, 12(5), 1139; https://doi.org/10.3390/diagnostics12051139
Submission received: 3 April 2022 / Revised: 1 May 2022 / Accepted: 2 May 2022 / Published: 4 May 2022
(This article belongs to the Special Issue Advances in the Diagnosis of Interstitial Lung Diseases)
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Abstract

In this study, it was found that myositis-specific and myositis-associated antibodies (MSAs and MAAs) improved the recognition of idiopathic inflammatory myopathies (IIMs) in interstitial lung disease (ILD) patients. The objective of this study is to propose a clinical method to evaluate myalgia in respiratory settings as a possible tool for the recognition of MSA/MAA positivity in ILD patients. We prospectively enrolled 167 ILD patients with suspected myositis, of which 63 had myalgia evoked at specific points (M+ILD+). We also enrolled in a 174 patients with only myalgia (M+ILD-) in a rheumatological setting. The patients were assessed jointly by rheumatologists and pulmonologists and were tested for autoantibodies. M+ILD+ patients were positive for at least one MAA/MSA in 68.3% of cases, as were M-ILD+ patients in 48.1% of cases and M+ILD- patients in 17.2% of cases (p = 0.01 and <0.0001, respectively). A diagnosis of IIM was made in 39.7% of M+ILD+ patients and in 23.1% of the M-ILD+ group (p = 0.02). Myalgia was significantly associated with positivity for MSA/MAAs in ILD patients (p = 0.01, X2: 6.47). In conclusion, myalgia in ILD patients with suspected myositis is associated with MSA/MAA positivity, and could support a diagnosis of IIM. A significant proportion of M+ILD- patients also had MSA/MAA positivity, a phenomenon warranting further study to evaluate its clinical meaning.
Keywords: myalgia; myositis; interstitial lung disease; tender points; autoantibodies; connective tissue disease; diagnosis; fibromyalgia myalgia; myositis; interstitial lung disease; tender points; autoantibodies; connective tissue disease; diagnosis; fibromyalgia

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MDPI and ACS Style

Sambataro, G.; Ferrara, C.A.; Spadaro, C.; Torrisi, S.E.; Vignigni, G.; Vancheri, A.; Muscato, G.; Del Papa, N.; Colaci, M.; Malatino, L.; et al. A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies. Diagnostics 2022, 12, 1139. https://doi.org/10.3390/diagnostics12051139

AMA Style

Sambataro G, Ferrara CA, Spadaro C, Torrisi SE, Vignigni G, Vancheri A, Muscato G, Del Papa N, Colaci M, Malatino L, et al. A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies. Diagnostics. 2022; 12(5):1139. https://doi.org/10.3390/diagnostics12051139

Chicago/Turabian Style

Sambataro, Gianluca, Chiara Alfia Ferrara, Carla Spadaro, Sebastiano Emanuele Torrisi, Giovanna Vignigni, Ada Vancheri, Giuseppe Muscato, Nicoletta Del Papa, Michele Colaci, Lorenzo Malatino, and et al. 2022. "A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies" Diagnostics 12, no. 5: 1139. https://doi.org/10.3390/diagnostics12051139

APA Style

Sambataro, G., Ferrara, C. A., Spadaro, C., Torrisi, S. E., Vignigni, G., Vancheri, A., Muscato, G., Del Papa, N., Colaci, M., Malatino, L., Palmucci, S., Cavagna, L., Zanframundo, G., Ferro, F., Baldini, C., Sambataro, D., & Vancheri, C. (2022). A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies. Diagnostics, 12(5), 1139. https://doi.org/10.3390/diagnostics12051139

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