Expression of CD44 in Leukocyte Subpopulations in Patients with Inflammatory Bowel Diseases
, Piero Marin Živković 3, Marino Vilović 4, Doris Rušić 5 and Joško Božić 4
Round 1
Reviewer 1 Report
The paper entitle "Expression of CD44 in leukocyte subpopulations in patients with inflammatory bowel diseases" addresses the putative role of differentiation and regulation of leukocytes in tailoring IBD therapeutic regimes. I think that it could be accept in present form; the work is well structured, the research design is appropriate, the methods and the results are clearly described and the discussion and conclusions are well supported by the results.
Author Response
Response to Reviewer 1 Comments
Point 1: The paper entitle "Expression of CD44 in leukocyte subpopulations in patients with inflammatory bowel diseases" addresses the putative role of differentiation and regulation of leukocytes in tailoring IBD therapeutic regimes. I think that it could be accept in present form; the work is well structured, the research design is appropriate, the methods and the results are clearly described and the discussion and conclusions are well supported by the results.
Response 1: We thank the honorable reviewer for the time spent reviewing our paper. Also, we are grateful for the positive comments.
Author Response File: 
Author Response.docx
Reviewer 2 Report
The manuscript entitled "Expression of CD44 in leukocyte subpopulations in patients with inflammatory bowel diseases" focuses on detection of CD44 expression in leukocyte subpopulations with regard to to the type of IBD, therapy, and disease duration. The authors show how the monocyte population is differentially regulated in Crohn's disease and Ulcerative colitis. In addition, how NBT differentially affects the leukocyte population in CD and UC. The study holds high importance as it is carried out in human patient samples and also has a good sample size.
Author Response
Response to Reviewer 2
Point 1: The manuscript entitled "Expression of CD44 in leukocyte subpopulations in patients with inflammatory bowel diseases" focuses on detection of CD44 expression in leukocyte subpopulations with regard to to the type of IBD, therapy, and disease duration. The authors show how the monocyte population is differentially regulated in Crohn's disease and Ulcerative colitis. In addition, how NBT differentially affects the leukocyte population in CD and UC. The study holds high importance as it is carried out in human patient samples and also has a good sample size.
Response 1: We thank the honorable reviewer 2 for the time spent reviewing our paper. Also, we are grateful for the positive comments.
Author Response File: Author Response.docx
