Diagnostic Accuracy of ki-67 Labeling Index in Endoscopic Ultrasonography-Fine-Needle Aspiration Cytology and Biopsy of Pancreatic Neuroendocrine Neoplasms
, Nae Yu Kim 2,†, Kyueng-Whan Min 1, Il Hwan Oh 2, Dae Hyun Lim 2 and Byoung Kwan Son 2,*Round 1
Reviewer 1 Report
The current paper is a meta-analytical review to evaluate the concordance rates of the Ki-67 labelling index between EUS-FNAC/FNB and surgical specimens. The authors also tried a subgroup analysis based on tumor grade, sampling method, and tumour size.
The present study is well-designed, and the analysis was good. The table, discussion and conclusions appears to be fine.
Author Response
Editor’s comment
Please note the need to extend the word count of the main text to at least 4000 words as you revise your manuscript.
Response) To the best of our knowledge, we have added to the text.
Reviewer 1.
The current paper is a meta-analytical review to evaluate the concordance rates of the Ki-67 labelling index between EUS-FNAC/FNB and surgical specimens. The authors also tried a subgroup analysis based on tumor grade, sampling method, and tumour size.
The present study is well-designed, and the analysis was good. The table, discussion and conclusions appears to be fine.
Response) Thank you for your careful review.
Reviewer 2 Report
Congrats for your study
Author Response
Editor’s comment
Please note the need to extend the word count of the main text to at least 4000 words as you revise your manuscript.
Response) To the best of our knowledge, we have added to the text.
Reviewer 2.
Congrats for your study
Response) Thank you for your careful review.
Reviewer 3 Report
1. A schematic diagram can be included for easier understanding of the findings and possible applications.
2. The conclusion section should be rewritten and include future directions.
Author Response
Editor’s comment
Please note the need to extend the word count of the main text to at least 4000 words as you revise your manuscript.
Response) To the best of our knowledge, we have added to the text.
Reviewer 3.
- A schematic diagram can be included for easier understanding of the findings and possible applications.
Response) Our study is a meta-analysis of the diagnostic accuracy of ki-67 labeling index in endoscopic ultrasonography-fine needle aspiration of pancreatic neuroendocrine neoplasms. As recommended by the reviewer, a schematic diagram is unfortunately difficult to add.
- The conclusion section should be rewritten and include future directions.
Response) We have added comments about future directions, as pointed out by the reviewer.
Round 2
Reviewer 3 Report
The revised manuscript looks better.
