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Volume 13
Issue 4
10.3390/diagnostics13040795
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Article

Timing of Early Postoperative MRI following Primary Glioblastoma Surgery—A Retrospective Study of Contrast Enhancements in 311 Patients

by
Alexander Malcolm Rykkje
1,2,*,
Vibeke Andrée Larsen
1,
Jane Skjøth-Rasmussen
3,
Michael Bachmann Nielsen
1,2,
Jonathan Frederik Carlsen
1 and
Adam Espe Hansen
1,2
1
Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
2
Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, Denmark
3
Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Diagnostics 2023, 13(4), 795; https://doi.org/10.3390/diagnostics13040795
Submission received: 8 January 2023 / Revised: 3 February 2023 / Accepted: 18 February 2023 / Published: 20 February 2023
(This article belongs to the Special Issue Advances in the Diagnostics and Therapies of Glioma)
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Abstract

An early postoperative MRI is recommended following Glioblastoma surgery. This retrospective, observational study aimed to investigate the timing of an early postoperative MRI among 311 patients. The patterns of the contrast enhancement (thin linear, thick linear, nodular, and diffuse) and time from surgery to the early postoperative MRI were recorded. The primary endpoint was the frequencies of the different contrast enhancements within and beyond the 48-h from surgery. The time dependence of the resection status and the clinical parameters were analysed as well. The frequency of the thin linear contrast enhancements significantly increased from 99/183 (50.8%) within 48-h post-surgery to 56/81 (69.1%) beyond 48-h post-surgery. Similarly, MRI scans with no contrast enhancements significantly declined from 41/183 (22.4%) within 48-h post-surgery to 7/81 (8.6%) beyond 48-h post-surgery. No significant differences were found for the other types of contrast enhancements and the results were robust in relation to the choice of categorisation of the postoperative periods. Both the resection status and the clinical parameters were not statistically different in patients with an MRI performed before and after 48 h. The findings suggest that surgically induced contrast enhancements are less frequent when an early postoperative MRI is performed earlier than 48-h, supporting the recommendation of a 48-h window for an early postoperative MRI.
Keywords: Glioblastoma; magnetic-resonance imaging; early postoperative MRI; postoperative period; postoperative enhancement; time window; neuroimaging Glioblastoma; magnetic-resonance imaging; early postoperative MRI; postoperative period; postoperative enhancement; time window; neuroimaging

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MDPI and ACS Style

Rykkje, A.M.; Larsen, V.A.; Skjøth-Rasmussen, J.; Nielsen, M.B.; Carlsen, J.F.; Hansen, A.E. Timing of Early Postoperative MRI following Primary Glioblastoma Surgery—A Retrospective Study of Contrast Enhancements in 311 Patients. Diagnostics 2023, 13, 795. https://doi.org/10.3390/diagnostics13040795

AMA Style

Rykkje AM, Larsen VA, Skjøth-Rasmussen J, Nielsen MB, Carlsen JF, Hansen AE. Timing of Early Postoperative MRI following Primary Glioblastoma Surgery—A Retrospective Study of Contrast Enhancements in 311 Patients. Diagnostics. 2023; 13(4):795. https://doi.org/10.3390/diagnostics13040795

Chicago/Turabian Style

Rykkje, Alexander Malcolm, Vibeke Andrée Larsen, Jane Skjøth-Rasmussen, Michael Bachmann Nielsen, Jonathan Frederik Carlsen, and Adam Espe Hansen. 2023. "Timing of Early Postoperative MRI following Primary Glioblastoma Surgery—A Retrospective Study of Contrast Enhancements in 311 Patients" Diagnostics 13, no. 4: 795. https://doi.org/10.3390/diagnostics13040795

APA Style

Rykkje, A. M., Larsen, V. A., Skjøth-Rasmussen, J., Nielsen, M. B., Carlsen, J. F., & Hansen, A. E. (2023). Timing of Early Postoperative MRI following Primary Glioblastoma Surgery—A Retrospective Study of Contrast Enhancements in 311 Patients. Diagnostics, 13(4), 795. https://doi.org/10.3390/diagnostics13040795

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