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Diagnostics
Volume 13
Issue 9
10.3390/diagnostics13091633
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Article
Peer-Review Record

Diffuse Reflectance Spectroscopy of the Oral Mucosa: In Vivo Experimental Validation of the Precancerous Lesions Early Detection Possibility

Diagnostics 2023, 13(9), 1633; https://doi.org/10.3390/diagnostics13091633
by Alexander V. Kolpakov 1,*, Anastasia A. Moshkova 1, Ekaterina V. Melikhova 1, Diana Yu. Sokolova 1, Natalia P. Muravskaya 1, Andrey V. Samorodov 1, Nina O. Kopaneva 2, Galina I. Lukina 2, Marina Ya. Abramova 2, Veta G. Mamatsashvili 2 and Vadim V. Parshkov 2
Reviewer 1: Anonymous
Reviewer 2:
Elisabetta Polizzi
Diagnostics 2023, 13(9), 1633; https://doi.org/10.3390/diagnostics13091633
Submission received: 12 April 2023 / Revised: 28 April 2023 / Accepted: 3 May 2023 / Published: 5 May 2023
(This article belongs to the Special Issue Optical Diagnostics and Monitoring of Human Diseases)

Round 1

Reviewer 1 Report

Grammatical errors need to be corrected. 

Referencing has to be corrected. 

Detailed comments have been included within the pdf file. 

There needs to be editing of the English text. Thorough grammatical review needs to be done. Punctuations has to be corrected. 

Author Response

Grammatical and punctuation errors  have been corrected

Referencing has been corrected (missed Ref. No 48 have been added, page 2)

Unfortunately the pdf file with detailed comments is unavailable

Reviewer 2 Report

article of a high scientific level and of interest to the research community!!! 

have you found differences with covid? have you ever thought about this research? 

have you investigated how the role of mast cells may affect inflammation and lesion development?

please read 

Tetè G, D'orto B, Ferrante L, Polizzi E, Cattoni F. Role of mast cells in oral inflammation. J Biol Regul Homeost Agents. 2021 Jul-Aug;35(4 Suppl. 1):65-70. doi: 10.23812/21-4supp1-6. PMID: 34425662.

Laishram D, Rao K, Devi HSU, Priya NS, Smitha T, Sheethal HS. Mast cells and angiogenesis in malignant and premalignant oral lesions: An immunohistochemical study. J Oral Maxillofac Pathol. 2017 May-Aug;21(2):229-238. doi: 10.4103/jomfp.JOMFP_111_15. PMID: 28932032; PMCID: PMC5596673.

 

there are some periods to be revised but no serious spelling errors 

Author Response

The changes in the DRS spectra  of the oral mucosa are correspond with the changes of mast cells during inflammation and lesion development described by [Tete G, et al.], [Laishram D., et al.].

As a further work, we plan a more detailed study of the correlation between changes in DRS spectra and histopathological changes in oral mucosa, including changes in mast cells, also as specifics  of lesions caused by COVID-19.   

Text  of the manuscript has been modified according to your recommendations  (p. 5, p.14).

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