The Usefulness of Line-Field Confocal Optical Coherence Tomography in Monitoring Epidermal Changes in Atopic Dermatitis in Response to Treatment: A Pilot Study
Abstract
:1. Introduction
1.1. Pathogenesis of Atopic Dermatitis
1.2. The Histology of Atopic Dermatitis
1.3. Therapeutic Implications
1.4. Dupilumab
1.5. Clinical Scoring
1.6. Line-Field Confocal Optical Coherence Tomography
2. Materials and Methods
2.1. Subjects and Biologic Treatment
2.2. Description of the Patients at Baseline
2.3. Clinical Scoring
2.4. The LC-OCT Image Acquisition Protocol
2.5. Dermoscopy Examination
2.6. The Imaging Parameters
2.7. Statistics
3. Results
3.1. Atopic Dermatitis in LC-OCT
3.2. Stratum Corneum Thickness
3.3. Stratum Corneum Disturbances
3.4. The Epidermal Thickness
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Age | Sex | EASI | cDLQI/DLQI | Previous Treatment | |
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Patient 1 | 14 | F | 20.4 | 12 | oral cyclosporine, short episodes of oral glicocorticosteroids, oral antihistamines, topical steroids, and emollients |
Patient 2 | 34 | F | 23.1 | 30 | oral cyclosporine, short episodes of oral glicocorticosteroids, topical steroids, and emollients |
Patient 3 | 32 | F | 33.1 | 23 | oral cyclosporine, UVB phototherapy, topical steroids, topical calcineurin inhibitors, and emollients |
Patient 4 | 24 | M | 21.3 | 10 | oral cyclosporine, short episodes of oral glicocorticosteroids, topical steroids, and emollients |
Patient 5 | 85 | M | 20.6 | 10 | oral cyclosporine, topical steroids, and emollients |
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Dryżałowska, Z.; Blicharz, L.; Michalczyk, A.; Koscian, J.; Maj, M.; Czuwara, J.; Rudnicka, L. The Usefulness of Line-Field Confocal Optical Coherence Tomography in Monitoring Epidermal Changes in Atopic Dermatitis in Response to Treatment: A Pilot Study. Diagnostics 2024, 14, 1724. https://doi.org/10.3390/diagnostics14161724
Dryżałowska Z, Blicharz L, Michalczyk A, Koscian J, Maj M, Czuwara J, Rudnicka L. The Usefulness of Line-Field Confocal Optical Coherence Tomography in Monitoring Epidermal Changes in Atopic Dermatitis in Response to Treatment: A Pilot Study. Diagnostics. 2024; 14(16):1724. https://doi.org/10.3390/diagnostics14161724
Chicago/Turabian StyleDryżałowska, Zuzanna, Leszek Blicharz, Agnieszka Michalczyk, Jan Koscian, Małgorzata Maj, Joanna Czuwara, and Lidia Rudnicka. 2024. "The Usefulness of Line-Field Confocal Optical Coherence Tomography in Monitoring Epidermal Changes in Atopic Dermatitis in Response to Treatment: A Pilot Study" Diagnostics 14, no. 16: 1724. https://doi.org/10.3390/diagnostics14161724