Ultrasound Assessment of Sarcopenia in Alcoholic Liver Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Inclusion Criteria
2.2. Ultrasound Assessment of Rectus Femoris
2.3. Statistical Analysis
3. Results
3.1. General Characteristics of Study Population
3.2. Clinical and Biological Results
3.3. Rectus Femoris Ultrasound Measurement Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Alcoholic Hepatitis | Alcoholic Cirrhosis | Method | p-Value |
---|---|---|---|---|
Number | 28 | 15 | - | - |
Sex (M/F) | 20 M/8 F | 10 M/5 F | Chi Square | 0.746 |
Age (years) | 53.89 (± 9.2) | 50.13 (±8.4) | ANOVA | 0.196 |
Ascites (0/1) | 12 (43%) | 0 | Chi Square | 0.003 * |
Encephalopathy (0/1) | 7 (25%) | 0 | Chi Square | 0.034 * |
Esophageal Varices (0/1) | 7 (25%) | 4 (26%) | Chi Square | 0.905 |
BMI (kg/m2) | 23.42 (±4.2) | 22.36 (±3.5) | T test | 0.440 |
WBC (×103 cells/uL) | 9.88 (±5) | 9.86 (±3.3) | T test | 0.988 |
PLT (×103 cells/uL) | 127.61 (±83) | 164.6 (±53) | T test | 0.126 |
INR | 1.7 (±0.3) | 1.53 (±0.3) | T test | 0.006 * |
ALT (U/L) | 49.86 (±29.3) | 58.33 (±22.7) | T test | 0.336 |
AST (U/L) | 134.11 (±71.4) | 66.6 (±24.9) | T test | 0.001 * |
Creatinine (mg/dL) | 0.59 (0.51–1.09) | 0.87(0.7–1.1) | M-W U | 0.161 |
Urea (mg/dL) | 26 (17–55) | 45 (41–54) | M-W U | 0.044 * |
Albumin (mg/dL) | 2.75 (±0.77) | 3.02 (±0.48) | T test | 0.380 |
Total Bilirubin (mg/dL) | 6.15 (4.67–12) | 1.8 (1.4–2.1) | M-W U | 0.001 * |
ALP (mg/dL) | 121 (94–169.5) | 42 (41–55) | M-W U | 0.001 * |
GGT (U/L) | 378 (122–768.75) | 60 (55–110) | M-W U | 0.001 * |
CRP (mg/dL) | 10.45 (3.15–26.5) | 0.7 (0.6–2.5) | M-W U | 0.001 * |
LDH (U/L) | 203 (170–250) | 80 (77–89) | M-W U | 0.001 * |
Sodium (mEq/L) | 131.43 (±7.32) | 135.2 (±2.95) | T test | 0.235 |
RFM (cm) | 1.34 (1.12–1.61) | 1.24 (1.03–1.65) | M-W U | 0.760 |
RFMS (m/s) | 1.78 (1.45–2.49) | 1.35 (1.22–1.45) | M-W U | 0.001 * |
RFE (0/1) | 22 (78.6%) | 8 (55.3%) | Chi Square | 0.086 |
30sCST (n) | 10.8 (±2.1) | 11.47(±2.23) | T test | 0.380 |
MELD | 17.07 (±7.24) | 11.41 (±3.45) | T test | 0.007 * |
MDF | 28.45 (25.2–58.44) | - | - | - |
Child–Pugh | - | A—6 (40%) B—9 (60%) | - | - |
Variable, r (p-Value) | RFM | RFMS |
---|---|---|
Age (years) | −0.178 (0.221) | 0.021 (0.887) |
BMI (kg/m2) | 0.320 (0.090) | −0.025 (0.620) |
PLT (×103) | 0.512 (<0.001) * | −0.034 (0.817) |
INR | −0.571 (<0.001) * | 0.309 (0.031) * |
Creatinine (mg/dL) | 0.217 (0.135) | 0.135 (0.355) |
Albumin (g/dL) | 0.549 (p < 0.001) * | −0.80 (0.585) |
RFM | - | 0.067 (0.647) |
RFMS | 0.067 (0.647) | - |
30sCST | 0.786 (p < 0.001) * | −0.444 (0.002) |
MDF | −0.514 (p < 0.001) * | 0.480 (<0.001) * |
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Enciu, V.-T.; Ologeanu, P.M.; Fierbinteanu-Braticevici, C. Ultrasound Assessment of Sarcopenia in Alcoholic Liver Disease. Diagnostics 2024, 14, 1891. https://doi.org/10.3390/diagnostics14171891
Enciu V-T, Ologeanu PM, Fierbinteanu-Braticevici C. Ultrasound Assessment of Sarcopenia in Alcoholic Liver Disease. Diagnostics. 2024; 14(17):1891. https://doi.org/10.3390/diagnostics14171891
Chicago/Turabian StyleEnciu, Vlad-Teodor, Priscila Madalina Ologeanu, and Carmen Fierbinteanu-Braticevici. 2024. "Ultrasound Assessment of Sarcopenia in Alcoholic Liver Disease" Diagnostics 14, no. 17: 1891. https://doi.org/10.3390/diagnostics14171891