The Systemic Risk Factors for the Development of Infectious Keratitis after Penetrating Keratoplasty: A Population-Based Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Source
2.2. Patient Selection
2.3. Main Outcome Definition
2.4. Systemic Co-Morbidity Enrollment
2.5. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. Risk Factors for Infectious Keratitis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characters | Number of Patients Who Received PK (N = 327) |
---|---|
Index year | |
2001–2003 | 85 (25.99%) |
2004–2006 | 53 (16.21%) |
2007–2009 | 54 (16.51%) |
2010–2012 | 56 (17.13%) |
2013–2016 | 79 (24.16%) |
Sex | |
Male | 183 (55.96%) |
Female | 144 (44.04%) |
Age | |
20–39 | 46 (14.07%) |
40–49 | 38 (11.62%) |
50–59 | 62 (18.96%) |
60–69 | 74 (22.63%) |
70–79 | 77 (23.55%) |
≥80 | 30 (9.17%) |
Urbanization | |
Urban | 195 (59.63%) |
Sub-urban | 94 (28.75%) |
Rural | 38 (11.62%) |
Systemic disease | |
Hypertension | 110 (33.64%) |
DM | 62 (18.96%) |
Chronic ischemic heart diseases | 32 (9.79%) |
Hyperlipidemia | 57 (17.43%) |
Cerebrovascular disease | 29 (8.87%) |
Allergic pulmonary diseases | 35 (10.70%) |
Rheumatic disease | 5 (1.53%) |
Allergic otolaryngologic diseases | 35 (10.70%) |
Allergic dermatological diseases | 73 (22.32%) |
Outcome | Patients Who Received PK (N = 327) |
---|---|
Follow-up person months | 25,131 |
Infectious keratitis | 68 (20.80%) |
Non-infectious keratitis | 259 (79.20%) |
Parameters | aHR | 95% CI | p-Value |
---|---|---|---|
Sex | |||
Male | Reference | ||
Female | 1.354 | 0.777–2.359 | 0.2850 |
Age | |||
20–39 | 0.212 | 0.052–0.864 | 0.0305 * |
40–49 | Reference | ||
50–59 | 0.716 | 0.288–1.780 | 0.4722 |
60–69 | 0.913 | 0.349–2.386 | 0.8524 |
70–79 | 0.791 | 0.297–2.107 | 0.6385 |
≥80 | 0.414 | 0.097–1.764 | 0.2331 |
Urbanization | |||
Urban | Reference | ||
Sub-urban | 1.027 | 0.533–1.978 | 0.9374 |
Rural | 1.144 | 0.456–2.867 | 0.7745 |
Systemic disease | |||
Hypertension | 1.224 | 0.678–2.210 | 0.5016 |
DM | 1.440 | 1.122–2.874 | 0.0310 * |
Chronic ischemic heart diseases | 1.534 | 1.259–3.464 | 0.0273 * |
Hyperlipidemia | 0.668 | 0.301–1.482 | 0.3211 |
Cerebrovascular disease | 0.570 | 0.200–1.624 | 0.2927 |
Allergic pulmonary diseases | 1.130 | 0.444–2.876 | 0.7972 |
Rheumatic disease | 0.693 | 0.083–5.785 | 0.7352 |
Allergic otolaryngologic diseases | 0.967 | 0.345–2.712 | 0.9494 |
Allergic dermatological diseases | 1.061 | 0.581–1.935 | 0.8477 |
Subgroup | aHR | 95% CI | p-Value |
---|---|---|---|
Age < 60 years | |||
DM | 1.382 | 1.004–2.966 | 0.0282 * |
Chronic ischemic heart disease | 0.880 | 0.597–1.296 | 0.5163 |
Age > 60 years | |||
DM | 1.690 | 1.458–3.039 | 0.0056 * |
Chronic ischemic heart disease | 1.856 | 1.403–5.881 | 0.0094 * |
Male | |||
DM | 1.876 | 1.240–3.421 | 0.0404 * |
Chronic ischemic heart disease | 1.919 | 1.376–4.465 | 0.0223 * |
Female | |||
DM | 1.278 | 1.015–2.460 | 0.0434 * |
Chronic ischemic heart disease | 1.141 | 1.144–2.119 | 0.0318 * |
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Hsu, Y.-N.; Chiang, W.-L.; Huang, J.-Y.; Lee, C.-Y.; Su, S.-C.; Yang, S.-F. The Systemic Risk Factors for the Development of Infectious Keratitis after Penetrating Keratoplasty: A Population-Based Cohort Study. Diagnostics 2024, 14, 2013. https://doi.org/10.3390/diagnostics14182013
Hsu Y-N, Chiang W-L, Huang J-Y, Lee C-Y, Su S-C, Yang S-F. The Systemic Risk Factors for the Development of Infectious Keratitis after Penetrating Keratoplasty: A Population-Based Cohort Study. Diagnostics. 2024; 14(18):2013. https://doi.org/10.3390/diagnostics14182013
Chicago/Turabian StyleHsu, Yung-Nan, Whei-Ling Chiang, Jing-Yang Huang, Chia-Yi Lee, Shih-Chi Su, and Shun-Fa Yang. 2024. "The Systemic Risk Factors for the Development of Infectious Keratitis after Penetrating Keratoplasty: A Population-Based Cohort Study" Diagnostics 14, no. 18: 2013. https://doi.org/10.3390/diagnostics14182013