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Open AccessArticle
Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression
by
Rashed Alhammad
Rashed Alhammad 1,*,
Milicia Allison
Milicia Allison 2,3,
Fares Alhammad
Fares Alhammad 4 and
Chinedu Anthony Anene
Chinedu Anthony Anene 2,5
1
Department of Pharmacology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
2
Centre for Cancer Biology and Therapy, School of Applied Science, London South Bank University, London SE1 0AA, UK
3
College of Science, Purdue University, West Lafayette, IN 47907, USA
4
Pediatrics Department, Sheikh Jaber Al-Ahmad Al-Sabah Hospital, Khalid Ben AbdulAziz Street, Sulaibikhat 13001, Kuwait
5
Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University, London EC1M 6BQ, UK
*
Author to whom correspondence should be addressed.
Diagnostics 2024, 14(19), 2227; https://doi.org/10.3390/diagnostics14192227 (registering DOI)
Submission received: 11 September 2024
/
Revised: 25 September 2024
/
Accepted: 28 September 2024
/
Published: 5 October 2024
Abstract
Background: Long non-coding RNAs (lncRNAs) are key regulators of cellular processes that underpin cancer development and progression. DRAIC is a migration inhibitor that has been linked with lung adenocarcinoma progression; however, its mechanisms remain to be studied. Methods: several bioinformatics tools were used to explore the role of DRAIC in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Results: Our bioinformatics analysis illustrates that patients with low expression of DRAIC have poor overall survival outcomes. In addition, the mRNA of SH3 domain-binding kinase 1 (SBK1) was downregulated in this cohort of patients. Mechanistic analysis showed that SBK1 is under the DRAIC competing endogenous RNAs network, potentially through sponging of miRNA-92a. Conclusion: Consistent dysregulation of the DRAIC-SBK1 axis was linked to poor survival outcome in both LUAD and LUSC, suggesting a tumour inhibitor role and providing potential for new diagnostics and therapeutic approaches.
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MDPI and ACS Style
Alhammad, R.; Allison, M.; Alhammad, F.; Anene, C.A.
Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression. Diagnostics 2024, 14, 2227.
https://doi.org/10.3390/diagnostics14192227
AMA Style
Alhammad R, Allison M, Alhammad F, Anene CA.
Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression. Diagnostics. 2024; 14(19):2227.
https://doi.org/10.3390/diagnostics14192227
Chicago/Turabian Style
Alhammad, Rashed, Milicia Allison, Fares Alhammad, and Chinedu Anthony Anene.
2024. "Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression" Diagnostics 14, no. 19: 2227.
https://doi.org/10.3390/diagnostics14192227
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