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Volume 14
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10.3390/diagnostics14020213
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Article

Weight Gain and Increased Body Mass Index in Patients with Hepatitis C after Eradication Using Direct-Acting Antiviral Therapy in Taiwan

by
Chun-Hsien Chen
1,
Yung-Yu Hsieh
1,2,
Wei-Ming Chen
1,2,
Chien-Heng Shen
1,
Kuo-Liang Wei
1,2,
Kao-Chi Chang
1,
Yuan-Jie Ding
1,
Sheng-Nan Lu
2,3,
Chao-Hung Hung
2,3 and
Te-Sheng Chang
1,2,*
1
Department of Gastroenterology and Hepatology, Division of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan
2
College of Medicine, Chang Gung University, Taoyuan 33303, Taiwan
3
Department of Gastroenterology and Hepatology, Division of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
*
Author to whom correspondence should be addressed.
Diagnostics 2024, 14(2), 213; https://doi.org/10.3390/diagnostics14020213
Submission received: 17 December 2023 / Revised: 14 January 2024 / Accepted: 17 January 2024 / Published: 19 January 2024
(This article belongs to the Section Clinical Laboratory Medicine)
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Abstract

Few studies have reported weight gain in patients with hepatitis C virus (HCV) infection treated with direct-acting antiviral agents (DAAs). This retrospective cohort study identified factors associated with substantial weight gain after DAA treatment in Taiwan. This study involved patients treated using DAAs at the Chiayi and Yunlin branches of Chang Gung Memorial Hospital from 1 January 2017 to 31 October 2020. Body weight data were collected at the start of DAA therapy and 2 years after the confirmation of a sustained virologic response. We performed multiple logistic regression to evaluate the clinical and laboratory parameters associated with a large body mass index (BMI) increase (≥5%). The mean BMI was 25.56 ± 4.07 kg/m2 at baseline and 25.77 ± 4.29 kg/m2 at the endpoint (p = 0.005). A considerable reduction in fibrosis-4 (FIB-4) score was a significant predictor of a large BMI increase (OR: 1.168; 95% CI: 1.047–1.304, p = 0.006). By contrast, older age (OR: 0.979; 95% CI: 0.963–0.996, p = 0.013) and a higher baseline BMI (OR: 0.907; 95% CI: 0.863–0.954, p < 0.001) were associated with a reduced risk of a large increase in BMI at the endpoint. In summary, a larger BMI increase was closely associated with a younger age, lower baseline BMI, and higher FIB-4 score reduction. Notably, differences in DAA regimens did not affect outcomes. Future studies are needed to elucidate the long-term effects and metabolic outcomes associated with this body weight change and investigate the exact underlying mechanisms.
Keywords: hepatitis C virus (HCV); direct-acting antiviral therapy; weight gain; obesity hepatitis C virus (HCV); direct-acting antiviral therapy; weight gain; obesity

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MDPI and ACS Style

Chen, C.-H.; Hsieh, Y.-Y.; Chen, W.-M.; Shen, C.-H.; Wei, K.-L.; Chang, K.-C.; Ding, Y.-J.; Lu, S.-N.; Hung, C.-H.; Chang, T.-S. Weight Gain and Increased Body Mass Index in Patients with Hepatitis C after Eradication Using Direct-Acting Antiviral Therapy in Taiwan. Diagnostics 2024, 14, 213. https://doi.org/10.3390/diagnostics14020213

AMA Style

Chen C-H, Hsieh Y-Y, Chen W-M, Shen C-H, Wei K-L, Chang K-C, Ding Y-J, Lu S-N, Hung C-H, Chang T-S. Weight Gain and Increased Body Mass Index in Patients with Hepatitis C after Eradication Using Direct-Acting Antiviral Therapy in Taiwan. Diagnostics. 2024; 14(2):213. https://doi.org/10.3390/diagnostics14020213

Chicago/Turabian Style

Chen, Chun-Hsien, Yung-Yu Hsieh, Wei-Ming Chen, Chien-Heng Shen, Kuo-Liang Wei, Kao-Chi Chang, Yuan-Jie Ding, Sheng-Nan Lu, Chao-Hung Hung, and Te-Sheng Chang. 2024. "Weight Gain and Increased Body Mass Index in Patients with Hepatitis C after Eradication Using Direct-Acting Antiviral Therapy in Taiwan" Diagnostics 14, no. 2: 213. https://doi.org/10.3390/diagnostics14020213

APA Style

Chen, C.-H., Hsieh, Y.-Y., Chen, W.-M., Shen, C.-H., Wei, K.-L., Chang, K.-C., Ding, Y.-J., Lu, S.-N., Hung, C.-H., & Chang, T.-S. (2024). Weight Gain and Increased Body Mass Index in Patients with Hepatitis C after Eradication Using Direct-Acting Antiviral Therapy in Taiwan. Diagnostics, 14(2), 213. https://doi.org/10.3390/diagnostics14020213

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