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Volume 14
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Article

Survival of Patients with Alcohol-Related Liver Disease Cirrhosis—Usefulness of the New Liver Mortality Inpatients Prognostic Score

by
Vera Matovic Zaric
1,*,
Ivana Pantic
2,
Sofija Lugonja
3,
Tijana Glisic
2,4,
Snezana Konjikusic
5,
Iva Lolic
1,
Nevena Baljosevic
1,
Sanja Zgradic
2,
Jasna El Mezeni
2,
Marko Vojnovic
2,
Marija Brankovic
4,6 and
Tamara Milovanovic
2,4
1
Emergency Center, Gastroenterology and Hepatology Department, University Clinical Center of Serbia, 11000 Belgrade, Serbia
2
Clinic of Gastroenterology and Hepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia
3
Department of Internal Medicine, Division of Gastroenterology, General Hospital “Djordje Joanovic”, 23000 Zrenjanin, Serbia
4
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
5
FEFA Faculty, Metropolitan University, 11000 Belgrade, Serbia
6
University Hospital Medical Center Bežanijska Kosa, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Diagnostics 2024, 14(22), 2508; https://doi.org/10.3390/diagnostics14222508
Submission received: 29 September 2024 / Revised: 3 November 2024 / Accepted: 4 November 2024 / Published: 9 November 2024
(This article belongs to the Special Issue Diagnosis, Treatment, and Prognosis of Liver Cirrhosis)
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Abstract

Background/Objectives: Alcohol can directly damage the liver, causing steatosis, steatohepatitis, cirrhosis, and hepatocellular cancer. The aim of this study was to examine 28-day survival in hospitalized patients with alcohol-related liver disease (ALD) cirrhosis, as well as to develop and validate a new survival prediction model. Methods: A total of 145 patients with ALD cirrhosis were included; 107 were diagnosed with acute decompensation (AD) and 38 with acute-on-chronic liver failure (ACLF). The new liver mortality inpatients (LIV-IN) score was calculated using the following variables: hepatic encephalopathy (HE), hepatorenal syndrome (HRS), ascites, systemic inflammatory response syndrome (SIRS), community-acquired infection (CAI), and fibrinogen. The diagnostic accuracy of the LIV-IN score was tested, along with the model for end-stage liver disease (MELD), model for end-stage liver disease-sodium (MELD-Na), albumin-bilirubin (ALBI), neutrophil-to-lymphocyte ratio (NLR), chronic liver failure consortium-C acute decompensation (CLIF-C AD), and chronic liver failure consortium-acute-on-chronic liver failure (CLIF-C ACLF). Results: Lethal outcome occurred in 46 (31.7%) patients. The mortality rate was higher in the ACLF group (n = 22, 57.9%) compared to the AD group (n = 24, 22.4%) (p < 0.01). The highest predictive power for short-term mortality was observed for the LIV-IN score (AUC 73.4%, p < 0.01). In patients with AD, the diagnostic accuracy of the CLIF-C AD score was better than for the LIV-IN score (AUC 0.699; p = 0.004, AUC 0.686; p = 0.007, respectively). In patients with ACLF, only the LIV-IN score had statistically significant discriminative power in predicting 28-day survival. Conclusions: The liver mortality inpatients prognostic score is a new, reliable prognostic model in predicting 28-day mortality.
Keywords: liver cirrhosis; survival; score liver cirrhosis; survival; score

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MDPI and ACS Style

Matovic Zaric, V.; Pantic, I.; Lugonja, S.; Glisic, T.; Konjikusic, S.; Lolic, I.; Baljosevic, N.; Zgradic, S.; El Mezeni, J.; Vojnovic, M.; et al. Survival of Patients with Alcohol-Related Liver Disease Cirrhosis—Usefulness of the New Liver Mortality Inpatients Prognostic Score. Diagnostics 2024, 14, 2508. https://doi.org/10.3390/diagnostics14222508

AMA Style

Matovic Zaric V, Pantic I, Lugonja S, Glisic T, Konjikusic S, Lolic I, Baljosevic N, Zgradic S, El Mezeni J, Vojnovic M, et al. Survival of Patients with Alcohol-Related Liver Disease Cirrhosis—Usefulness of the New Liver Mortality Inpatients Prognostic Score. Diagnostics. 2024; 14(22):2508. https://doi.org/10.3390/diagnostics14222508

Chicago/Turabian Style

Matovic Zaric, Vera, Ivana Pantic, Sofija Lugonja, Tijana Glisic, Snezana Konjikusic, Iva Lolic, Nevena Baljosevic, Sanja Zgradic, Jasna El Mezeni, Marko Vojnovic, and et al. 2024. "Survival of Patients with Alcohol-Related Liver Disease Cirrhosis—Usefulness of the New Liver Mortality Inpatients Prognostic Score" Diagnostics 14, no. 22: 2508. https://doi.org/10.3390/diagnostics14222508

APA Style

Matovic Zaric, V., Pantic, I., Lugonja, S., Glisic, T., Konjikusic, S., Lolic, I., Baljosevic, N., Zgradic, S., El Mezeni, J., Vojnovic, M., Brankovic, M., & Milovanovic, T. (2024). Survival of Patients with Alcohol-Related Liver Disease Cirrhosis—Usefulness of the New Liver Mortality Inpatients Prognostic Score. Diagnostics, 14(22), 2508. https://doi.org/10.3390/diagnostics14222508

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