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Diagnostics
Volume 14
Issue 3
10.3390/diagnostics14030258
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Case Report
Peer-Review Record

Juvenile Primary Sjögren Syndrome in a 15-Year-Old Boy with Renal Involvement: A Case Report and Review of the Literature

Diagnostics 2024, 14(3), 258; https://doi.org/10.3390/diagnostics14030258
by Katerina Bouchalova 1,*, Hana Flögelova 1,*, Pavel Horak 2, Jakub Civrny 3, Petr Mlcak 4, Richard Pink 5, Jaroslav Michalek 6, Petra Camborova 7, Zuzana Mikulkova 8 and Eva Kriegova 8
Reviewer 1:
Sezgin Sahin
Reviewer 2: Anonymous
Diagnostics 2024, 14(3), 258; https://doi.org/10.3390/diagnostics14030258
Submission received: 22 December 2023 / Revised: 16 January 2024 / Accepted: 19 January 2024 / Published: 25 January 2024
(This article belongs to the Section Clinical Laboratory Medicine)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

A very interesting case presented with high quality and supported by amazing figures and literature. Sjögren syndrome is a rare autoimmune disease in childhood which is also possibly overlooked by clinicians. I would like to congratulate the authors for their motivation to diagnose the patient who even has no autoantibody positivity. I have only 2 minor concern:

1) The meaning of the first sentence of the abstract is not clear. Please, rephrase

2) I am wondering if the patient has undergone any test to detect any ocular dryness. Please, explain.

 

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The authors reported a juvenile case of Sjögren’s syndrome (SS) complicating tubulointerstitial nephritis, and stated the patient was compatible with 2016 ACR-EULAR SS criteria. However, there are several uncertain points about the diagnosis.

1.       Existence of subjective sicca symptoms is required as inclusion criteria of 2016 ACR-EULAR SS criteria, which is not clear in Case Description.

2.       Line 107 to 109: ‘Labial salivary gland biopsy was non-diagnostic, however, the subman- dibular one supported SS. Lymphocytic foci (i.e. foci with more than 50 lymphocytes) were found in the number of 5 per 4 mm2 of tissue.’ In 2016 ACR-EULAR SS criteria, ‘Labial salivary gland with focal lymphocytic sialadenitis and focus score of≧1 foci/4 mm2’ is stated.

3.       How about results of ocular staining score?

4.       How about anti-Ro/SS-A antibodies? Negative results of ANA do not always exclude possibility of positive anti-Ro/SS-A antibodies.

5.       Did the authors all exclusion criteria in 2016 ACR-EULAR SS criteria? The explanation in Line 104 ‘Further workup excluded IgG4-related and other diseases.’ is not satisfactory.

6.       Considering above, the authors had better consider the other classification criteria for SS, such as 2012 SICCA criteria and e 2002 American-European Consensus Group SS classification criteria

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Comments and Suggestions for Authors

(No further comments)

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