Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination
Abstract
:1. Introduction
2. Materials and Methods
2.1. Inclusion and Exclusion Criteria
2.2. Outpatient Procedure
2.3. Statistical Analyses
2.4. Ethical Approval
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Total | Post Menopause Abnormal Uterine Bleeding (AUB) | Post Menopause Endometrial Thickening | Pre Menopause Endometrial Thickening | |
---|---|---|---|---|
Patients (n) | 424 | 92 | 225 | 107 |
Age (years) | 49.6 ± 4.2 | 51.0 ± 5.9 | 57.4 ± 3.2 | 41.3 ± 3.4 |
Weight (Kg) | 67.1 ± 5.2 | 69.4 ± 3.4 | 68.3 ± 4.5 | 64.1 ± 4.5 |
Body-Mass Index (Kg/m2) | 23.9 ± 4.3 | 24.2 ± 6.1 | 24.1 ± 5.6 | 24.7 ± 5.9 |
Diagnosis | Hysteroscopy | Histopathology | p Value | |
---|---|---|---|---|
Correlates | Does Not Correlate | |||
Normal/Benign | 127 | 109 (85.8) | 18 (14.1) | 0.0001 |
Endometrial Hyperplasia | 283 | 165 (58.3) | 118 (41.7) | 0.0001 |
Atypical Hyperplasia/Carcinoma | 14 | 14 (100) | 0 | 0.0065 |
TOTAL | 424 | 288 (67.9) | 136 (32.1) | 0.0001 |
Diagnosis | Hysteroscopy | Histopathology | p Value | |
---|---|---|---|---|
Correlates | Does Not Correlate | |||
AUB in Post-Menopause | ||||
Normal/Benign | 26 | 21 (80.8) | 5 (19.2) | 0.0176 |
Endometrial Hyperplasia | 64 | 33 (51.6) | 31 (48.4) | 0.0059 |
Atypical Hyperplasia/Carcinoma | 2 | 2 (100) | 0 | 0.5184 |
TOTAL | 92 | 56 (60.9) | 36 (39.1) | 0.0150 |
Endometrial Thickening in Post-Menopause | ||||
Normal/Benign | 47 | 45 (95.7) | 2 (4.3) | 0.0001 |
Endometrial Hyperplasia | 166 | 94 (56.6) | 72 (43.4) | 0.0001 |
Atypical Hyperplasia/Carcinoma | 12 | 12 (100) | 0 | 0.0099 |
TOTAL | 225 | 151 (67.1) | 74 (32.9) | 0.0001 |
Endometrial Thickening in Pre-menopause | ||||
Normal/Benign | 54 | 49 (90.7) | 5 (9.3) | 0.0076 |
Endometrial Hyperplasia | 53 | 37 (69.8) | 16 (30.2) | 0.0076 |
Atypical Hyperplasia/Carcinoma | 0 | 0 | 0 | NA |
TOTAL | 107 | 86 (80.4) | 21 (19.6) | 0.0080 |
Total | AUB in Postmenopause | Endometrial Thickening in Postmenopause | Endometrial Thickening in Premenopause | |
---|---|---|---|---|
Sensitivity | 90.4 (87.1–93.0) | 86.8 (77.8–92.7) | 97.9 (94.7–93.3) | 88.1 (80.1–93.3) |
Specificity | 48.9 (44.1–53.8) | 42.6 (32.5–53.3) | 39.5 (33.0–46.4) | 75.4 (65.9–83.0) |
Pre-test | 44.2 (53.6–63.1) | 41.3 (31.3–52.1) | 44.7 (37.9–51.6) | 39.3 (30.1–49.2) |
PPV | 58.4 (53.6–63.1) | 51.6 (41.0–62.0) | 56.6 (49.7–63.3) | 69.8 (60.1–78.1) |
NPV | 86.6 (82.9–89.6) | 82.1 (72.5–89.1) | 95.9 (92.1–98.0) | 90.7 (83.2–95.2) |
LR+ | 1.77 (1.54–2.03) | 1.51 (1.01–2.11) | 1.59 (1.26–2.00) | 3.58 (3.01–4.27) |
LR− | 0.14 (0.11–0.19) | 0.30 (0.22–0.43) | 0.05(0.04–0.06) | 0.15 (0.13–0.18) |
Post test (+) | 0.58 (0.52–0.64) | 0.51 (0.37–0.65) | 0.56 (0.47–0.65) | 0.69 (0.58–0.79) |
Post test (−) | 0.13 (0.04–0.22) | 0.17 (0.01–0.37) | 0.04 (0.02–0.16) | 0.01 (0.01–0.21) |
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De Franciscis, P.; Riemma, G.; Schiattarella, A.; Cobellis, L.; Guadagno, M.; Vitale, S.G.; Mosca, L.; Cianci, A.; Colacurci, N. Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination. Diagnostics 2019, 9, 142. https://doi.org/10.3390/diagnostics9040142
De Franciscis P, Riemma G, Schiattarella A, Cobellis L, Guadagno M, Vitale SG, Mosca L, Cianci A, Colacurci N. Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination. Diagnostics. 2019; 9(4):142. https://doi.org/10.3390/diagnostics9040142
Chicago/Turabian StyleDe Franciscis, Pasquale, Gaetano Riemma, Antonio Schiattarella, Luigi Cobellis, Maria Guadagno, Salvatore Giovanni Vitale, Lavinia Mosca, Antonio Cianci, and Nicola Colacurci. 2019. "Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination" Diagnostics 9, no. 4: 142. https://doi.org/10.3390/diagnostics9040142