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Diagnostics
Volume 9
Issue 4
10.3390/diagnostics9040143
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Article
Peer-Review Record

Increased Serum Parathyroid Hormone, Osteocalcin and Alkaline Phosphatase Are Associated with a Long-Term Adverse Cardiovascular Outcome after Coronary Artery Bypass Graft Surgery

Diagnostics 2019, 9(4), 143; https://doi.org/10.3390/diagnostics9040143
by Olga Barbarash 1,2, Mikhail Zykov 1, Vasiliy Kashtalap 1,2, Oksana Hryachkova 1, Alexandr Kokov 1, Olga Gruzdeva 1, Irina Shibanova 1 and Anton Kutikhin 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Diagnostics 2019, 9(4), 143; https://doi.org/10.3390/diagnostics9040143
Submission received: 11 September 2019 / Revised: 3 October 2019 / Accepted: 5 October 2019 / Published: 8 October 2019
(This article belongs to the Section Pathology and Molecular Diagnostics)

Round 1

Reviewer 1 Report

In this study, the authors stated the association between bone turnover markers with an adverse cardiovascular outcome 3 years after CABG surgery. Although limited to the sample size, duration of follow-up and treatment regiments, the current study still provided a novel way in prognostication after CABG surgery by preoperative screening of bone turnover markers in patients regardless of osteopoenia/osteoporosis, coronary/peripheral atherosclerosis, and CAC.

The study was well conducted and easy to follow. The topic is interesting and relevant to the field of this journal. Subject definitions and methods were described clearly. Tables were used to present complicated information in a way that is accessible and understandable to the reader.

Therefore, I recommend acceptance of this paper for publication.

Author Response

We sincerely thank the reviewer for his/her valuable comments.

Reviewer 2 Report

In this manuscript, the authors showed several makers, which has significant difference between favorable and adverse outcome after 3 years’ surgery of CABG. The data provided new makers from serum, indicating that serum PTH, osteocalcin, and alkaline phosphatase could be makers for patients with adverse outcome, and also found that CABG surgery is not associated with osteopenia/osteoporosis, coronary/peripheral atherosclerosis and CAC.

 

The data from clinical are solid and can be used as indicators. However, there are some concerns needed to improve.

 

Alkaline phosphatase, which is common maker for most of patient with heart failure, may not be good marker for outcome after 3 years of surgery. For instance, even though the authors argued that there were no significant difference between CABG and other diseases such as Stroke, chronic heart failure, hypertension, and Type 2 diabetes mellitus and obesity, alkaline phosphatase may be also increased in these diseases.

 

In addition, regarding the markers, which has significant difference between favorable and adverse outcome, are those different in obesity, or diabetes, as well as male and female.

 

The authors studies the data after 3 years’ of surgery, how about early phase, which could be more helpful if some makers exist.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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