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Pathogens
Volume 10
Issue 11
10.3390/pathogens10111523
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Case Report

The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report

by
Florentina Dumitrescu
1,†,
Cătălina-Gabriela Pisoschi
2,†,
Vlad Pădureanu
3,*,
Andreea Cristina Stoian
1,
Livia Dragonu
1 and
Lucian Giubelan
1
1
Department of Infectious Disease, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
*
Author to whom correspondence should be addressed.
†
The authors contributed equally to this work.
Pathogens 2021, 10(11), 1523; https://doi.org/10.3390/pathogens10111523
Submission received: 22 October 2021 / Revised: 19 November 2021 / Accepted: 20 November 2021 / Published: 21 November 2021
(This article belongs to the Special Issue Recent Advances and Challenges in Tuberculosis Research)
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Abstract

Tuberculosis (TB) is an important opportunistic infection in HIV-positive people. We are reporting a case of a 31-year-old HIV-infected patient who was hospitalized in July 2021 for dyspnea, cough with mucopurulent sputum and asthenia. He was confirmed to have Serratia liquefaciens pneumonia and acute respiratory failure. The evolution was unfavorable despite the antibiotic, pathogenic and symptomatic treatment. Because the patient had severe immunosuppression (CD4 count = 37 cell/mm3), we used QuantiFERON-TB Gold Plus for the detection of the Mycobacterium tuberculosis infection. The antituberculosis therapy was initiated, which resulted in a significant improvement of the general condition and the patient was discharged with the recommendation to continue antiretroviral therapy, antituberculosis treatment and Trimethoprim/Sulfamethoxazole—single tablet daily for the prophylaxis of Pneumocystis pneumonia.
Keywords: HIV; tuberculosis; infection; QuantiFERON-TB HIV; tuberculosis; infection; QuantiFERON-TB

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MDPI and ACS Style

Dumitrescu, F.; Pisoschi, C.-G.; Pădureanu, V.; Stoian, A.C.; Dragonu, L.; Giubelan, L. The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report. Pathogens 2021, 10, 1523. https://doi.org/10.3390/pathogens10111523

AMA Style

Dumitrescu F, Pisoschi C-G, Pădureanu V, Stoian AC, Dragonu L, Giubelan L. The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report. Pathogens. 2021; 10(11):1523. https://doi.org/10.3390/pathogens10111523

Chicago/Turabian Style

Dumitrescu, Florentina, Cătălina-Gabriela Pisoschi, Vlad Pădureanu, Andreea Cristina Stoian, Livia Dragonu, and Lucian Giubelan. 2021. "The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report" Pathogens 10, no. 11: 1523. https://doi.org/10.3390/pathogens10111523

APA Style

Dumitrescu, F., Pisoschi, C.-G., Pădureanu, V., Stoian, A. C., Dragonu, L., & Giubelan, L. (2021). The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report. Pathogens, 10(11), 1523. https://doi.org/10.3390/pathogens10111523

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