Pathogens, Volume 11, Issue 2
February 2022 - 169 articles
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
- You may sign up for email alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story: Shigella is a highly infectious human pathogen responsible for 269 million reported cases and 200,000 deaths per year. Its virulence relies on the activity of the ATPase Spa47 to power the injection of effector proteins into human host cells through the needle-like type three secretion system injectisome. Here, we explore the effects of recently identified posttranslational tyrosine phosphorylation in Spa47 using a myriad of in vitro and in vivo protein characterization and pathogen phenotyping techniques. The results uncover a striking correlation between Spa47 tyrosine phosphorylation state, Spa47 ATPase activity, T3SS function, and Shigella virulence, suggesting that posttranslational tyrosine phosphorylation represents a potent means for native regulation of Shigella virulence and a much-needed target for non-antibiotic therapeutics. View this paper