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Pathogens, Volume 11, Issue 2

February 2022 - 169 articles

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Cover Story: Shigella is a highly infectious human pathogen responsible for 269 million reported cases and 200,000 deaths per year. Its virulence relies on the activity of the ATPase Spa47 to power the injection of effector proteins into human host cells through the needle-like type three secretion system injectisome. Here, we explore the effects of recently identified posttranslational tyrosine phosphorylation in Spa47 using a myriad of in vitro and in vivo protein characterization and pathogen phenotyping techniques. The results uncover a striking correlation between Spa47 tyrosine phosphorylation state, Spa47 ATPase activity, T3SS function, and Shigella virulence, suggesting that posttranslational tyrosine phosphorylation represents a potent means for native regulation of Shigella virulence and a much-needed target for non-antibiotic therapeutics. View this paper

Articles (169)

  • Article
  • Open Access
4 Citations
3,632 Views
6 Pages

21 February 2022

Yersinia enterocolitica and Y. pseudotuberculosis are important causes of enteric illness worldwide. Rapid response to suspected foodborne outbreaks is hampered by the widespread use of cold enrichment methods that require incubation periods of 10&nd...

  • Article
  • Open Access
4 Citations
2,537 Views
10 Pages

21 February 2022

Highly specific and sensitive diagnostic methods are vital for the effective control and treatment of toxoplasmosis. Routine diagnosis is primarily serological because T. gondii infections stimulate persistently high IgG antibody responses. The sensi...

  • Article
  • Open Access
10 Citations
2,773 Views
12 Pages

20 February 2022

Radiologists should be aware of the findings of alveolar echinococcosis (AE) due to the diagnostic and management value of imaging. We are attempting to define the most common diagnostic imaging findings of liver AE, along with the prevalence and dis...

  • Review
  • Open Access
13 Citations
6,265 Views
38 Pages

SARS-CoV-2 and Coronavirus Disease Mitigation: Treatment Options, Vaccinations and Variants

  • Almu’atasim Khamees,
  • Jamal Bani-Issa,
  • Mazhar Salim Al Zoubi,
  • Taqwa Qasem,
  • Manal Issam AbuAlArjah,
  • Sura Ahmad Alawadin,
  • Khayry Al-Shami,
  • Farah E. Hussein,
  • Emad Hussein and
  • Ibrahim H. Bashayreh
  • + 3 authors

20 February 2022

COVID-19 is caused by a novel coronavirus (2019-nCoV), which was declared as a pandemic after it emerged in China 2019. A vast international effort has been conducted to prevent and treat COVID-19 due to its high transmissibility and severe morbidity...

  • Review
  • Open Access
49 Citations
7,932 Views
22 Pages

Adaptive Cellular Immunity against African Swine Fever Virus Infections

  • Alexander Schäfer,
  • Giulia Franzoni,
  • Christopher L. Netherton,
  • Luise Hartmann,
  • Sandra Blome and
  • Ulrike Blohm

20 February 2022

African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T...

  • Review
  • Open Access
182 Citations
14,800 Views
21 Pages

Major Biological Control Strategies for Plant Pathogens

  • Manisha Arora Pandit,
  • Jitendra Kumar,
  • Saloni Gulati,
  • Neeru Bhandari,
  • Poonam Mehta,
  • Roma Katyal,
  • Charu Dogra Rawat,
  • Vachaspati Mishra and
  • Jasleen Kaur

19 February 2022

Food security has become a major concern worldwide in recent years due to ever increasing population. Providing food for the growing billions without disturbing environmental balance is incessantly required in the current scenario. In view of this, s...

  • Article
  • Open Access
3 Citations
2,280 Views
11 Pages

More Insights about the Efficacy of Copper Ion Treatment on Mycobacterium avium subsp. paratuberculosis (MAP): A Clue for the Observed Tolerance

  • Carlos Tejeda,
  • Pamela Steuer,
  • Marcela Villegas,
  • Angelica Reyes-Jara,
  • Esperanza C. Iranzo,
  • Reydoret Umaña and
  • Miguel Salgado

19 February 2022

Background: Scientific evidence is scarce for the antimicrobial effect of copper on bacteria characterized as more resistant. Using Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant microorganism, as a pathogen model, copper ion t...

  • Review
  • Open Access
67 Citations
19,744 Views
25 Pages

19 February 2022

The handling of highly pathogenic viruses, whether for diagnostic or research purposes, often requires an inactivation step. This article reviews available inactivation techniques published in peer-reviewed journals and their benefits and limitations...

  • Systematic Review
  • Open Access
436 Citations
25,483 Views
14 Pages

19 February 2022

Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms...

  • Hypothesis
  • Open Access
9 Citations
2,933 Views
9 Pages

19 February 2022

Background: Obesity is a risk factor for the development of influenza by leading to a chronic inflammatory state and T-cell dysfunction. Based upon preclinical research, metformin has influenza activity by restoring T-cell function and improving the...

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