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Pathogens
Volume 12
Issue 1
10.3390/pathogens12010023
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Management of Rat Lungworm Disease (Neuroangiostrongyliasis) Using Anthelmintics: Recent Updates and Recommendations

by
John Jacob
,
Argon Steel
,
Kathleen Howe
and
Susan Jarvi
*
Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA
*
Author to whom correspondence should be addressed.
Pathogens 2023, 12(1), 23; https://doi.org/10.3390/pathogens12010023
Submission received: 1 December 2022 / Revised: 20 December 2022 / Accepted: 20 December 2022 / Published: 23 December 2022
(This article belongs to the Special Issue Rat Lungworm Disease)
Versions Notes

Abstract

While there have been legitimate concerns in the past regarding the use of anthelmintics for the management of neuroangiostrongyliasis (rat lungworm disease), recent studies demonstrate that they can be considered safe and efficacious, particularly albendazole, which is regarded as the choice anthelmintic for its management. However, physician hesitancy to prescribe, as well as problems of availability persist, at least in Hawaii, which is considered the epicenter of this disease in the US. As a result, many patients suffer a diminished quality of life or even death. Here, we discuss recent studies that provide insights into new treatments and preventative interventions, which can be more rigorously used for the management of neuroangiostrongyliasis. In summary, results from recent studies suggest that albendazole and avermectins are beneficial for post-exposure management, pyrantel pamoate is beneficial as a post-exposure prophylactic, and levamisole is deserving of further study for the treatment of neuroangiostrongyliasis.
Keywords: rat lungworm; neuroangiostrongyliasis; treatment; anthelmintics; albendazole; pyrantel pamoate rat lungworm; neuroangiostrongyliasis; treatment; anthelmintics; albendazole; pyrantel pamoate

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MDPI and ACS Style

Jacob, J.; Steel, A.; Howe, K.; Jarvi, S. Management of Rat Lungworm Disease (Neuroangiostrongyliasis) Using Anthelmintics: Recent Updates and Recommendations. Pathogens 2023, 12, 23. https://doi.org/10.3390/pathogens12010023

AMA Style

Jacob J, Steel A, Howe K, Jarvi S. Management of Rat Lungworm Disease (Neuroangiostrongyliasis) Using Anthelmintics: Recent Updates and Recommendations. Pathogens. 2023; 12(1):23. https://doi.org/10.3390/pathogens12010023

Chicago/Turabian Style

Jacob, John, Argon Steel, Kathleen Howe, and Susan Jarvi. 2023. "Management of Rat Lungworm Disease (Neuroangiostrongyliasis) Using Anthelmintics: Recent Updates and Recommendations" Pathogens 12, no. 1: 23. https://doi.org/10.3390/pathogens12010023

APA Style

Jacob, J., Steel, A., Howe, K., & Jarvi, S. (2023). Management of Rat Lungworm Disease (Neuroangiostrongyliasis) Using Anthelmintics: Recent Updates and Recommendations. Pathogens, 12(1), 23. https://doi.org/10.3390/pathogens12010023

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