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Volume 13
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10.3390/pathogens13090796
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Article

Metabolic Footprint of Treponema phagedenis and Treponema pedis Reveals Potential Interaction Towards Community Succession and Pathogenesis in Bovine Digital Dermatitis

by
Hector M. Espiritu
1,
Edeneil Jerome P. Valete
1,
Lovelia L. Mamuad
1,
Myunghwan Jung
2,
Man-Jeong Paik
3,
Sang-Suk Lee
1 and
Yong-Il Cho
1,*
1
Department of Animal Science and Technology, Sunchon National University, Suncheon-si 57922, Jeollanam-do, Republic of Korea
2
Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju 52727, Gyeongsangnam-do, Republic of Korea
3
College of Pharmacy, Sunchon National University, Suncheon-si 57922, Jeollanam-do, Republic of Korea
*
Author to whom correspondence should be addressed.
Pathogens 2024, 13(9), 796; https://doi.org/10.3390/pathogens13090796
Submission received: 16 August 2024 / Revised: 4 September 2024 / Accepted: 10 September 2024 / Published: 14 September 2024
(This article belongs to the Section Bacterial Pathogens)
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Abstract

Bovine digital dermatitis (BDD) is a cattle infection causing hoof lesions and lameness, with treponemes as key pathogens. We analyzed the metabolic activity of Treponema phagedenis and Treponema pedis using gas chromatography–mass spectrometry for organic acids (OAs), amino acids (AAs), and fatty acids (FAs), and high-performance liquid chromatography for short-chain fatty acids (SCFAs). Key findings include a 61.5% reduction in pyruvic acid in T. pedis and 81.0% in T. phagedenis. 2-hydroxybutyric acid increased by 493.8% in T. pedis, while succinic acid increased by 31.3%, potentially supporting T. phagedenis. Among AAs, glycine was reduced by 97.4% in T. pedis but increased by 64.1% in T. phagedenis. Proline increased by 76.6% in T. pedis but decreased by 13.6% in T. phagedenis. Methionine and glutamic acid were competitively utilized, with methionine reduced by 41.8% in T. pedis and 11.9% in T. phagedenis. Both species showed significant utilization of palmitic acid (reduced by 82.8% in T. pedis and 87.2% in T. phagedenis). Butyric acid production increased by 620.2% in T. phagedenis, and propionic acid increased by 932.8% in T. pedis and 395.6% in T. phagedenis. These reveal metabolic interactions between the pathogens, contributing to disease progression and offering insights to BDD pathogenesis.
Keywords: bovine digital dermatitis; Treponema; exometabolomics; polymicrobial disease bovine digital dermatitis; Treponema; exometabolomics; polymicrobial disease

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MDPI and ACS Style

Espiritu, H.M.; Valete, E.J.P.; Mamuad, L.L.; Jung, M.; Paik, M.-J.; Lee, S.-S.; Cho, Y.-I. Metabolic Footprint of Treponema phagedenis and Treponema pedis Reveals Potential Interaction Towards Community Succession and Pathogenesis in Bovine Digital Dermatitis. Pathogens 2024, 13, 796. https://doi.org/10.3390/pathogens13090796

AMA Style

Espiritu HM, Valete EJP, Mamuad LL, Jung M, Paik M-J, Lee S-S, Cho Y-I. Metabolic Footprint of Treponema phagedenis and Treponema pedis Reveals Potential Interaction Towards Community Succession and Pathogenesis in Bovine Digital Dermatitis. Pathogens. 2024; 13(9):796. https://doi.org/10.3390/pathogens13090796

Chicago/Turabian Style

Espiritu, Hector M., Edeneil Jerome P. Valete, Lovelia L. Mamuad, Myunghwan Jung, Man-Jeong Paik, Sang-Suk Lee, and Yong-Il Cho. 2024. "Metabolic Footprint of Treponema phagedenis and Treponema pedis Reveals Potential Interaction Towards Community Succession and Pathogenesis in Bovine Digital Dermatitis" Pathogens 13, no. 9: 796. https://doi.org/10.3390/pathogens13090796

APA Style

Espiritu, H. M., Valete, E. J. P., Mamuad, L. L., Jung, M., Paik, M.-J., Lee, S.-S., & Cho, Y.-I. (2024). Metabolic Footprint of Treponema phagedenis and Treponema pedis Reveals Potential Interaction Towards Community Succession and Pathogenesis in Bovine Digital Dermatitis. Pathogens, 13(9), 796. https://doi.org/10.3390/pathogens13090796

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